Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309763676> ?p ?o ?g. }
- W4309763676 endingPage "31" @default.
- W4309763676 startingPage "16" @default.
- W4309763676 abstract "The extracellular matrix (ECM) in the endometrium plays a crucial role in mammalian pregnancy. We have shown that versican secreted from the endometrial epithelium promotes embryo implantation. Versican is a proteoglycan, a major player in the provisional matrix, and versikine, its N-terminal fragment cleaved by ADAMTS proteinases, serves as a bioactive molecule. Here, since versican expression in the placenta was dynamically altered in humans and mice, we investigated the role of versican in pregnancy using uterine-specific Vcan deletion mice (uKO mice) and ADAMTS-resistant versican expressing mice (V1R mice). uKO mice exhibited insufficient spiral artery dilation, followed by fetal growth restriction and maternal hypertension. Further analysis revealed impaired proliferation of tissue-resident natural killer cells required for spiral artery dilation. V1R mice showed the same results as the control, eliminating the involvement of versikine. Our results provide a new concept that versican, one factor of ECM, contributes to placentation and following fetal growth." @default.
- W4309763676 created "2022-11-29" @default.
- W4309763676 creator A5002628288 @default.
- W4309763676 creator A5017583270 @default.
- W4309763676 creator A5028464951 @default.
- W4309763676 creator A5030224196 @default.
- W4309763676 creator A5044404375 @default.
- W4309763676 creator A5051800836 @default.
- W4309763676 creator A5054221507 @default.
- W4309763676 creator A5064070422 @default.
- W4309763676 creator A5064965347 @default.
- W4309763676 creator A5078583769 @default.
- W4309763676 creator A5087182097 @default.
- W4309763676 creator A5088477434 @default.
- W4309763676 creator A5088883992 @default.
- W4309763676 creator A5089286168 @default.
- W4309763676 date "2023-01-01" @default.
- W4309763676 modified "2023-10-01" @default.
- W4309763676 title "Versican provides the provisional matrix for uterine spiral artery dilation and fetal growth" @default.
- W4309763676 cites W1607376345 @default.
- W4309763676 cites W1995869857 @default.
- W4309763676 cites W2006494078 @default.
- W4309763676 cites W2028003472 @default.
- W4309763676 cites W2032380839 @default.
- W4309763676 cites W2052823936 @default.
- W4309763676 cites W2062106375 @default.
- W4309763676 cites W2064122707 @default.
- W4309763676 cites W2075724573 @default.
- W4309763676 cites W2078538657 @default.
- W4309763676 cites W2101482318 @default.
- W4309763676 cites W2116015859 @default.
- W4309763676 cites W2117255043 @default.
- W4309763676 cites W2120798610 @default.
- W4309763676 cites W2128466784 @default.
- W4309763676 cites W2141295972 @default.
- W4309763676 cites W2148734624 @default.
- W4309763676 cites W2166223726 @default.
- W4309763676 cites W2171463972 @default.
- W4309763676 cites W2292377799 @default.
- W4309763676 cites W2325839131 @default.
- W4309763676 cites W2559861360 @default.
- W4309763676 cites W2775921812 @default.
- W4309763676 cites W2808401869 @default.
- W4309763676 cites W2892842252 @default.
- W4309763676 cites W2893064836 @default.
- W4309763676 cites W2900144939 @default.
- W4309763676 cites W2900846703 @default.
- W4309763676 cites W2911999717 @default.
- W4309763676 cites W2936726901 @default.
- W4309763676 cites W2941564859 @default.
- W4309763676 cites W2962388486 @default.
- W4309763676 cites W2967444508 @default.
- W4309763676 cites W2981861497 @default.
- W4309763676 cites W2995931780 @default.
- W4309763676 cites W3033214241 @default.
- W4309763676 cites W3086777726 @default.
- W4309763676 cites W3119767369 @default.
- W4309763676 cites W4098901 @default.
- W4309763676 doi "https://doi.org/10.1016/j.matbio.2022.11.004" @default.
- W4309763676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36423736" @default.
- W4309763676 hasPublicationYear "2023" @default.
- W4309763676 type Work @default.
- W4309763676 citedByCount "0" @default.
- W4309763676 crossrefType "journal-article" @default.
- W4309763676 hasAuthorship W4309763676A5002628288 @default.
- W4309763676 hasAuthorship W4309763676A5017583270 @default.
- W4309763676 hasAuthorship W4309763676A5028464951 @default.
- W4309763676 hasAuthorship W4309763676A5030224196 @default.
- W4309763676 hasAuthorship W4309763676A5044404375 @default.
- W4309763676 hasAuthorship W4309763676A5051800836 @default.
- W4309763676 hasAuthorship W4309763676A5054221507 @default.
- W4309763676 hasAuthorship W4309763676A5064070422 @default.
- W4309763676 hasAuthorship W4309763676A5064965347 @default.
- W4309763676 hasAuthorship W4309763676A5078583769 @default.
- W4309763676 hasAuthorship W4309763676A5087182097 @default.
- W4309763676 hasAuthorship W4309763676A5088477434 @default.
- W4309763676 hasAuthorship W4309763676A5088883992 @default.
- W4309763676 hasAuthorship W4309763676A5089286168 @default.
- W4309763676 hasBestOaLocation W43097636761 @default.
- W4309763676 hasConcept C105702510 @default.
- W4309763676 hasConcept C109523444 @default.
- W4309763676 hasConcept C159470946 @default.
- W4309763676 hasConcept C16685009 @default.
- W4309763676 hasConcept C167814343 @default.
- W4309763676 hasConcept C172680121 @default.
- W4309763676 hasConcept C185592680 @default.
- W4309763676 hasConcept C189165786 @default.
- W4309763676 hasConcept C2776224515 @default.
- W4309763676 hasConcept C2776953305 @default.
- W4309763676 hasConcept C2779234561 @default.
- W4309763676 hasConcept C2779335624 @default.
- W4309763676 hasConcept C2780771523 @default.
- W4309763676 hasConcept C45167389 @default.
- W4309763676 hasConcept C54355233 @default.
- W4309763676 hasConcept C55493867 @default.
- W4309763676 hasConcept C55728118 @default.
- W4309763676 hasConcept C71924100 @default.
- W4309763676 hasConcept C86803240 @default.