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• W4309764154 endingPage "103765" @default.
• W4309764154 startingPage "103765" @default.
• W4309764154 abstract "The detailed mechanism underlying endometriosis development remains unclear; few reports have suggested the involvement of immune and genetic factors. This study aims to investigate the role of NK cells in endometriosis by analyzing the co-expression of activating (NKp46, NKG2C, and NKG2D) and inhibitory receptors (NKG2A and CD158a) on NK cells and their subsequent cytokine production in the peritoneal fluid (PF). Sixty-two patients were enrolled for this study from Hyogo Medical University between February 2018 and April 2022. Results showed that the proportions of CD56+/NKp46+, CD56dim/NKp46＋, NKG2C＋/NKp46＋, and NKG2D＋/NKp46＋ NK cells were significantly lower in the endometriosis group than those in the control group. Meanwhile, within the peritoneal endometriosis (n = 21) and deep infiltrating endometriosis (n = 11) groups, the co-expression of NKG2D＋/NKp46＋ and CD16＋/NKp46＋. Additionally, the abundance of IFN-γ-producing NK cells was significantly increased in the endometriosis group compared to controls, and a significant negative correlation was noted between NKp46 expression on NK cells and type 1 cytokine (IFN-γ and TNF-α) production. Taken together, the findings of this study indicate that NK cell cytotoxicity in endometriosis is reduced due to changes in NKp46 expression, as well as activating receptors co-expressed with NKp46. Consequently, NK cells do not eliminate endometrial cells in the abdominal cavity, resulting in the production of TNF-α and IFN-γ." @default.
• W4309764154 created "2022-11-29" @default.
• W4309764154 creator A5010660159 @default.
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• W4309764154 date "2023-02-01" @default.
• W4309764154 modified "2023-10-16" @default.
• W4309764154 title "Co-expression of activating and inhibitory receptors on peritoneal fluid NK cells in women with endometriosis" @default.
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• W4309764154 doi "https://doi.org/10.1016/j.jri.2022.103765" @default.
• W4309764154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36442371" @default.
• W4309764154 hasPublicationYear "2023" @default.
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