Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309764571> ?p ?o ?g. }
- W4309764571 endingPage "121213" @default.
- W4309764571 startingPage "121213" @default.
- W4309764571 abstract "The objective of this study is to provide a reliable strategy for the diagnosis of sarcopenia based on a complementary combination of biomarkers from various approaches.A total of 30 C57BL/6J mice were used for the experiment, in which 15 young mice (YM) at 24 weeks old and 15 aged mice (AM) at 88 weeks old. Extracted features-based digital biomarkers from the electromyography activity of tibialis anterior muscles were evaluated by using receiver operating characteristic analysis. Extracted tissular proteins and circulating hormones based chemical biomarkers were investigated by using immunoblotting and enzyme-linked immunosorbent assay.In terms of digital biomarkers, the feature-based classification of mice groups showed good performance (Feature A: AUC = 0.986, accuracy = 0.928) and (Feature B: AUC = 0.999, accuracy = 0.990). On the other hand, muscle-specific protein levels based chemical biomarkers (e.g. MuRF1, FoxO1, and perilipin2) were observed significantly increase with age. Pro-inflammatory cytokines based biomarkers extracted from muscle tissue and circulating plasma (e.g. TNF-α, IL-6, and IL-8) were significantly higher in case of AM group compared to YM group. Circulating hormone-based chemical biomarkers (e.g. cortisol/DHEA ratio and cathepsin D) presented a significant increase in concentrations with age. Circulating neurotransmitter based biomarkers (e.g. acetylcholine, serotonin, and histamine) also increased significantly in concentrations from YM to AM.A complementary combination of digital and chemical biomarkers covers multiple domains of sarcopenia to provide an effective strategy for the early diagnosis of sarcopenia." @default.
- W4309764571 created "2022-11-29" @default.
- W4309764571 creator A5008452010 @default.
- W4309764571 creator A5012514567 @default.
- W4309764571 creator A5022526006 @default.
- W4309764571 creator A5024478619 @default.
- W4309764571 creator A5046382663 @default.
- W4309764571 creator A5050699178 @default.
- W4309764571 creator A5056282479 @default.
- W4309764571 creator A5064382500 @default.
- W4309764571 creator A5085803998 @default.
- W4309764571 date "2023-01-01" @default.
- W4309764571 modified "2023-10-16" @default.
- W4309764571 title "Complementary combination of biomarkers for diagnosis of sarcopenia in C57BL/6J mice" @default.
- W4309764571 cites W1493610819 @default.
- W4309764571 cites W1978345502 @default.
- W4309764571 cites W1999765859 @default.
- W4309764571 cites W2039509275 @default.
- W4309764571 cites W2041090814 @default.
- W4309764571 cites W2046119060 @default.
- W4309764571 cites W2056710503 @default.
- W4309764571 cites W2086717365 @default.
- W4309764571 cites W2117547584 @default.
- W4309764571 cites W2122939763 @default.
- W4309764571 cites W2126072473 @default.
- W4309764571 cites W2150780222 @default.
- W4309764571 cites W2151606589 @default.
- W4309764571 cites W2158698691 @default.
- W4309764571 cites W2221102702 @default.
- W4309764571 cites W2290508886 @default.
- W4309764571 cites W2338054221 @default.
- W4309764571 cites W2346376580 @default.
- W4309764571 cites W2483527297 @default.
- W4309764571 cites W2519065211 @default.
- W4309764571 cites W2522105642 @default.
- W4309764571 cites W2533928101 @default.
- W4309764571 cites W2536212044 @default.
- W4309764571 cites W2553464641 @default.
- W4309764571 cites W2734377645 @default.
- W4309764571 cites W2749024777 @default.
- W4309764571 cites W2775422686 @default.
- W4309764571 cites W2777886152 @default.
- W4309764571 cites W2790056846 @default.
- W4309764571 cites W2806172637 @default.
- W4309764571 cites W2884388698 @default.
- W4309764571 cites W2886239325 @default.
- W4309764571 cites W2895679601 @default.
- W4309764571 cites W2897513125 @default.
- W4309764571 cites W2905229149 @default.
- W4309764571 cites W2912867695 @default.
- W4309764571 cites W2918408501 @default.
- W4309764571 cites W2918761953 @default.
- W4309764571 cites W2960199440 @default.
- W4309764571 cites W2981890331 @default.
- W4309764571 cites W3001849356 @default.
- W4309764571 cites W3005437800 @default.
- W4309764571 cites W3033199665 @default.
- W4309764571 cites W3033651486 @default.
- W4309764571 cites W3086251256 @default.
- W4309764571 cites W3093210925 @default.
- W4309764571 cites W3093794286 @default.
- W4309764571 cites W3138158211 @default.
- W4309764571 cites W3163021717 @default.
- W4309764571 cites W3163281568 @default.
- W4309764571 cites W3186065666 @default.
- W4309764571 cites W3198540629 @default.
- W4309764571 cites W3205964983 @default.
- W4309764571 cites W4200247103 @default.
- W4309764571 cites W4211144975 @default.
- W4309764571 cites W4221073130 @default.
- W4309764571 cites W4223655604 @default.
- W4309764571 cites W4226238020 @default.
- W4309764571 doi "https://doi.org/10.1016/j.lfs.2022.121213" @default.
- W4309764571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36423671" @default.
- W4309764571 hasPublicationYear "2023" @default.
- W4309764571 type Work @default.
- W4309764571 citedByCount "2" @default.
- W4309764571 countsByYear W43097645712023 @default.
- W4309764571 crossrefType "journal-article" @default.
- W4309764571 hasAuthorship W4309764571A5008452010 @default.
- W4309764571 hasAuthorship W4309764571A5012514567 @default.
- W4309764571 hasAuthorship W4309764571A5022526006 @default.
- W4309764571 hasAuthorship W4309764571A5024478619 @default.
- W4309764571 hasAuthorship W4309764571A5046382663 @default.
- W4309764571 hasAuthorship W4309764571A5050699178 @default.
- W4309764571 hasAuthorship W4309764571A5056282479 @default.
- W4309764571 hasAuthorship W4309764571A5064382500 @default.
- W4309764571 hasAuthorship W4309764571A5085803998 @default.
- W4309764571 hasConcept C126322002 @default.
- W4309764571 hasConcept C134018914 @default.
- W4309764571 hasConcept C170493617 @default.
- W4309764571 hasConcept C185592680 @default.
- W4309764571 hasConcept C2775864247 @default.
- W4309764571 hasConcept C2776214593 @default.
- W4309764571 hasConcept C2779959927 @default.
- W4309764571 hasConcept C58471807 @default.
- W4309764571 hasConcept C71924100 @default.
- W4309764571 hasConceptScore W4309764571C126322002 @default.