FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309772085> ?p ?o ?g. }

• W4309772085 endingPage "42" @default.
• W4309772085 startingPage "36" @default.
• W4309772085 abstract "We aimed to investigate the effect of apocynin (APO) on delayed afterdepolarizations (DADs) in rat atrial myocytes and the underlying mechanisms. Rat atrial myocytes were isolated by a Langendorff perfusion apparatus. DADs were induced by isoproterenol (ISO). Action potentials (APs) and ion currents were recorded by the whole-cell clamp technique. The fluorescent indicator fluo-4 was used to visualize intracellular Ca2+ transients, and western blotting was used to measure the expression of related proteins. The incidence of DADs in rat atrial myocytes increased significantly after ISO treatment, leading to an increased incidence of triggered activity (TA). The incidence of ISO-induced DADs and TA were reduced by 100.0 μM APO from 48.89% to 25.56% and 17.78% to 5.56%, respectively. In the range of 3.0 μM-300.0 μM, the effect of APO was concentration dependent, with a half maximal inhibitory concentration (IC50) of 120.1 μM and a Hill coefficient of 1.063. APO reversed the increase in transient inward current (Iti) and Na+/Ca2+-exchange current (INCX) densities induced by ISO in atrial myocytes. The frequency of spontaneous Ca2+ transients in atrial myocytes was reduced by 100.0 μM APO. Compared with ISO, APO downregulated the expression of NOX2 and increased the phosphorylation of PLNSer16 and the sarcoplasmic reticulum Ca2+-ATPase-2a (SERCA2a) level; however, it had little effect on ryanodine-receptor channel type-2 (RyR2). These findings showed that APO may block Iti and INCX and reduce intracellular Ca2+ levels in rat atrial myocytes, thus reducing the incidence of ISO-induced DADs and TA." @default.
• W4309772085 created "2022-11-29" @default.
• W4309772085 creator A5009318195 @default.
• W4309772085 creator A5021293751 @default.
• W4309772085 creator A5023638756 @default.
• W4309772085 creator A5045359066 @default.
• W4309772085 creator A5058893507 @default.
• W4309772085 creator A5061584932 @default.
• W4309772085 creator A5064842058 @default.
• W4309772085 creator A5077595112 @default.
• W4309772085 creator A5084743111 @default.
• W4309772085 date "2023-01-01" @default.
• W4309772085 modified "2023-10-09" @default.
• W4309772085 title "Effects of apocynin on ISO-induced delayed afterdepolarizations in rat atrial myocytes and the underlying mechanisms" @default.
• W4309772085 cites W2091209544 @default.
• W4309772085 cites W2145254041 @default.
• W4309772085 cites W2155155195 @default.
• W4309772085 cites W2172180641 @default.
• W4309772085 cites W2408076582 @default.
• W4309772085 cites W2491103610 @default.
• W4309772085 cites W2625916659 @default.
• W4309772085 cites W2894212902 @default.
• W4309772085 cites W2995139090 @default.
• W4309772085 cites W3090337303 @default.
• W4309772085 cites W3108147899 @default.
• W4309772085 cites W3123126572 @default.
• W4309772085 cites W3126104474 @default.
• W4309772085 cites W4220984077 @default.
• W4309772085 cites W4223534056 @default.
• W4309772085 doi "https://doi.org/10.1016/j.bbrc.2022.11.053" @default.
• W4309772085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36436340" @default.
• W4309772085 hasPublicationYear "2023" @default.
• W4309772085 type Work @default.
• W4309772085 citedByCount "0" @default.
• W4309772085 crossrefType "journal-article" @default.
• W4309772085 hasAuthorship W4309772085A5009318195 @default.
• W4309772085 hasAuthorship W4309772085A5021293751 @default.
• W4309772085 hasAuthorship W4309772085A5023638756 @default.
• W4309772085 hasAuthorship W4309772085A5045359066 @default.
• W4309772085 hasAuthorship W4309772085A5058893507 @default.
• W4309772085 hasAuthorship W4309772085A5061584932 @default.
• W4309772085 hasAuthorship W4309772085A5064842058 @default.
• W4309772085 hasAuthorship W4309772085A5077595112 @default.
• W4309772085 hasAuthorship W4309772085A5084743111 @default.
• W4309772085 hasBestOaLocation W43097720851 @default.
• W4309772085 hasConcept C113217602 @default.
• W4309772085 hasConcept C12554922 @default.
• W4309772085 hasConcept C126322002 @default.
• W4309772085 hasConcept C134018914 @default.
• W4309772085 hasConcept C146403970 @default.
• W4309772085 hasConcept C147944092 @default.
• W4309772085 hasConcept C155164980 @default.
• W4309772085 hasConcept C155730078 @default.
• W4309772085 hasConcept C158617107 @default.
• W4309772085 hasConcept C170488646 @default.
• W4309772085 hasConcept C170493617 @default.
• W4309772085 hasConcept C17137333 @default.
• W4309772085 hasConcept C181199279 @default.
• W4309772085 hasConcept C185263204 @default.
• W4309772085 hasConcept C185592680 @default.
• W4309772085 hasConcept C207200792 @default.
• W4309772085 hasConcept C23265538 @default.
• W4309772085 hasConcept C2780383360 @default.
• W4309772085 hasConcept C2781414619 @default.
• W4309772085 hasConcept C55493867 @default.
• W4309772085 hasConcept C71924100 @default.
• W4309772085 hasConcept C79879829 @default.
• W4309772085 hasConcept C86803240 @default.
• W4309772085 hasConceptScore W4309772085C113217602 @default.
• W4309772085 hasConceptScore W4309772085C12554922 @default.
• W4309772085 hasConceptScore W4309772085C126322002 @default.
• W4309772085 hasConceptScore W4309772085C134018914 @default.
• W4309772085 hasConceptScore W4309772085C146403970 @default.
• W4309772085 hasConceptScore W4309772085C147944092 @default.
• W4309772085 hasConceptScore W4309772085C155164980 @default.
• W4309772085 hasConceptScore W4309772085C155730078 @default.
• W4309772085 hasConceptScore W4309772085C158617107 @default.
• W4309772085 hasConceptScore W4309772085C170488646 @default.
• W4309772085 hasConceptScore W4309772085C170493617 @default.
• W4309772085 hasConceptScore W4309772085C17137333 @default.
• W4309772085 hasConceptScore W4309772085C181199279 @default.
• W4309772085 hasConceptScore W4309772085C185263204 @default.
• W4309772085 hasConceptScore W4309772085C185592680 @default.
• W4309772085 hasConceptScore W4309772085C207200792 @default.
• W4309772085 hasConceptScore W4309772085C23265538 @default.
• W4309772085 hasConceptScore W4309772085C2780383360 @default.
• W4309772085 hasConceptScore W4309772085C2781414619 @default.
• W4309772085 hasConceptScore W4309772085C55493867 @default.
• W4309772085 hasConceptScore W4309772085C71924100 @default.
• W4309772085 hasConceptScore W4309772085C79879829 @default.
• W4309772085 hasConceptScore W4309772085C86803240 @default.
• W4309772085 hasFunder F4320321001 @default.
• W4309772085 hasLocation W43097720851 @default.
• W4309772085 hasLocation W43097720852 @default.
• W4309772085 hasOpenAccess W4309772085 @default.
• W4309772085 hasPrimaryLocation W43097720851 @default.
• W4309772085 hasRelatedWork W1965320459 @default.
• W4309772085 hasRelatedWork W2040813536 @default.

• next