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• W4309774531 endingPage "100563" @default.
• W4309774531 startingPage "100563" @default.
• W4309774531 abstract "Autism spectrum disorder (ASD) is a complicated neurodevelopmental disorder, which is categorized by deficiency of social contact and communication, and stereotyped forms of performance. Meningeal immunity conditions the immune reflection and immune defense in the meningeal area involving meningeal lymphatic organization, glymphatic structure, immune cells, and cytokines. The development of meningeal immunity dysfunction might be the leading cause for many neural diseases including ASD. The inbred mouse strain BTBRT + Itpr3tf/J (BTBR) shows multiple ASD-like behavioral phenotypes, thus making this strain a widely used animal model for ASD. In our previous study, we reported an altered peripheral immune profile in BTBR mice. Herein, we are investigating immunological and neural interactions associated with the aberrant behavior of BTBR mice. BTBR mice have an increased level of immune cell deposition in the meninges along with a higher level of CD4+ T cells expressing CD25 and of B and myeloid cells expressing more MHCII than C57BL/6 (B6) mice, which have normal behaviors. BTBR mice also have higher levels of autoantibodies to dsDNA, Aquaporin-4, NMDAR1, Pentraxin/SAP and Caspr2 than B6 mice, which may affect neural functions. Interestingly, the T regulatory (Treg) cell population and their function was significantly reduced in the meninges and brain draining lymph nodes, which may explain the increased level of activated B and T cells in the meninges of BTBR mice. A low level of Treg cells, less IL-10 production by Treg, and activated T and B cells in meninges together with higher autoantibody levels might contribute to the development of autism-like behavior through neuroinflammation, which is known to be increased in BTBR mice." @default.
• W4309774531 created "2022-11-29" @default.
• W4309774531 creator A5036891184 @default.
• W4309774531 creator A5053216437 @default.
• W4309774531 creator A5079609217 @default.
• W4309774531 date "2022-12-01" @default.
• W4309774531 modified "2023-09-30" @default.
• W4309774531 title "Altered meningeal immunity contributing to the autism-like behavior of BTBR T Itpr3/J mice" @default.
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• W4309774531 doi "https://doi.org/10.1016/j.bbih.2022.100563" @default.
• W4309774531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36439055" @default.
• W4309774531 hasPublicationYear "2022" @default.
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