Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309779761> ?p ?o ?g. }
- W4309779761 endingPage "24" @default.
- W4309779761 startingPage "18" @default.
- W4309779761 abstract "Immune thrombocytopenia (ITP), is an acquired autoimmune disorder characterized by the destruction of platelets and megakaryocytes, resulting in thrombocytopenia (platelet count <100 × 10⁹/L). This review focuses on the diagnosis and current management of ITP. The diagnosis of ITP is based principally on the exclusion of other causes of isolated thrombocytopenia using patient history, physical examination, blood count, and evaluation of the peripheral blood film. The clinical treatment goals should be to resolve bleeding events and to prevent severe bleeding episodes. The platelet count should be improved to attain a minimum of > 20-30 × 10⁹/L. Therapy should be given as an inpatient in newly diagnosed ITP with a platelet count of > 20 × 10⁹/L or if there is active bleeding. Corticosteroids are considered the standard initial treatment for newly diagnosed patients. Subsequent medical therapies with robust evidence include thrombopoietin receptor agonists (TPO-RAs), rituximab and fostamatinib. Surgical therapy with splenectomy may be considered for patients failing medical therapy. The choice between therapy options is highly dependent upon patient values and preferences." @default.
- W4309779761 created "2022-11-29" @default.
- W4309779761 creator A5059876271 @default.
- W4309779761 date "2023-02-01" @default.
- W4309779761 modified "2023-09-23" @default.
- W4309779761 title "Current approaches for the diagnosis and management of immune thrombocytopenia" @default.
- W4309779761 cites W1496534390 @default.
- W4309779761 cites W1509374036 @default.
- W4309779761 cites W1509820083 @default.
- W4309779761 cites W1530712347 @default.
- W4309779761 cites W1533645201 @default.
- W4309779761 cites W1554903070 @default.
- W4309779761 cites W1573994325 @default.
- W4309779761 cites W1940859004 @default.
- W4309779761 cites W1972576558 @default.
- W4309779761 cites W1982651554 @default.
- W4309779761 cites W1984073642 @default.
- W4309779761 cites W1989118573 @default.
- W4309779761 cites W1991596704 @default.
- W4309779761 cites W1993960588 @default.
- W4309779761 cites W2004216230 @default.
- W4309779761 cites W2008303641 @default.
- W4309779761 cites W2009389738 @default.
- W4309779761 cites W2011342000 @default.
- W4309779761 cites W2012551171 @default.
- W4309779761 cites W2024023466 @default.
- W4309779761 cites W2026016649 @default.
- W4309779761 cites W2027093124 @default.
- W4309779761 cites W2031404496 @default.
- W4309779761 cites W2033207183 @default.
- W4309779761 cites W2034922203 @default.
- W4309779761 cites W2039002753 @default.
- W4309779761 cites W2040271292 @default.
- W4309779761 cites W2045711502 @default.
- W4309779761 cites W2055075605 @default.
- W4309779761 cites W2055617656 @default.
- W4309779761 cites W2059418185 @default.
- W4309779761 cites W2064053509 @default.
- W4309779761 cites W2067861049 @default.
- W4309779761 cites W2074887437 @default.
- W4309779761 cites W2079071994 @default.
- W4309779761 cites W2100380027 @default.
- W4309779761 cites W2104778351 @default.
- W4309779761 cites W2105320555 @default.
- W4309779761 cites W2114630396 @default.
- W4309779761 cites W2122735473 @default.
- W4309779761 cites W2133872135 @default.
- W4309779761 cites W2147255241 @default.
- W4309779761 cites W2147981786 @default.
- W4309779761 cites W2151165602 @default.
- W4309779761 cites W2160919909 @default.
- W4309779761 cites W2297883415 @default.
- W4309779761 cites W2340926419 @default.
- W4309779761 cites W2342664814 @default.
- W4309779761 cites W2396250791 @default.
- W4309779761 cites W2482272827 @default.
- W4309779761 cites W2520058836 @default.
- W4309779761 cites W2557563345 @default.
- W4309779761 cites W2594852169 @default.
- W4309779761 cites W2602518840 @default.
- W4309779761 cites W2763817611 @default.
- W4309779761 cites W2765458598 @default.
- W4309779761 cites W2793207073 @default.
- W4309779761 cites W2799711263 @default.
- W4309779761 cites W2801927229 @default.
- W4309779761 cites W2838077948 @default.
- W4309779761 cites W2891845585 @default.
- W4309779761 cites W2902437774 @default.
- W4309779761 cites W2916734627 @default.
- W4309779761 cites W2944617176 @default.
- W4309779761 cites W2972154418 @default.
- W4309779761 cites W2975593667 @default.
- W4309779761 cites W2993666578 @default.
- W4309779761 cites W3015587704 @default.
- W4309779761 cites W3021302733 @default.
- W4309779761 cites W3044441835 @default.
- W4309779761 cites W3157120261 @default.
- W4309779761 cites W3184564817 @default.
- W4309779761 cites W3186015355 @default.
- W4309779761 cites W3202008440 @default.
- W4309779761 cites W4200282829 @default.
- W4309779761 cites W4211106014 @default.
- W4309779761 cites W4232025330 @default.
- W4309779761 cites W4232398392 @default.
- W4309779761 cites W4234607402 @default.
- W4309779761 cites W4280512248 @default.
- W4309779761 cites W4283379419 @default.
- W4309779761 cites W941376371 @default.
- W4309779761 doi "https://doi.org/10.1016/j.ejim.2022.11.022" @default.
- W4309779761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36424271" @default.
- W4309779761 hasPublicationYear "2023" @default.
- W4309779761 type Work @default.
- W4309779761 citedByCount "0" @default.
- W4309779761 crossrefType "journal-article" @default.
- W4309779761 hasAuthorship W4309779761A5059876271 @default.
- W4309779761 hasConcept C109159458 @default.
- W4309779761 hasConcept C126322002 @default.
- W4309779761 hasConcept C177713679 @default.