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• W4309780288 abstract "Cognitive and neuropsychiatric disturbances in Parkinson's disease are as common and as disabling as its well-known motor symptoms. Even though several neural substrates for these symptoms have been suggested, to which extent these symptoms reflect cortical neurodegeneration in Parkinson’s disease remains to be fully elucidated. In a representative sample of 44 Parkinson’s disease patients, the data about the following symptoms was recorded: cognitive performance, apathy, depression and anxiety. Surface-based vertexwise multiple regression analyses were performed to investigate the cortical macro (cortical thinning) and microstructural (increased intracortical diffusivity) correlates of each symptom. A group of 18 healthy controls with similar sociodemographics was also included to assess the disease specificity of the neuroimaging results. Compared to healthy controls, Parkinson’s disease patients showed significantly increased scores in all the considered non-motor scales (p < 0.01). Within the Parkinson’s disease group, increased scores in these scales were associated with cortical macro- and microstructural neurodegeneration (p < 0.05 corrected). Each of the considered non-motor scales was associated with a specific pattern of cortical degeneration. When observing both neuroimaging techniques, intracortical diffusivity revealed similar but extensive patterns of cortical compromise than cortical thickness for each symptom, with the exception of anxiety. Cognitive and neuropsychiatric symptoms in Parkinson’s disease reflect cortical degeneration. Increases in intracortical diffusivity were able to detect symptom-specific cortical microstructural damage in the absence of cortical thinning. A better understanding of this association may contribute to characterize the brain circuitry and the neurotransmitter pathways underlying these highly prevalent and debilitating symptoms in Parkinson’s disease." @default.
• W4309780288 created "2022-11-29" @default.
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• W4309780288 date "2023-01-01" @default.
• W4309780288 modified "2023-10-16" @default.
• W4309780288 title "Cortical macro and microstructural correlates of cognitive and neuropsychiatric symptoms in Parkinson’s disease" @default.
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• W4309780288 doi "https://doi.org/10.1016/j.clineuro.2022.107531" @default.
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