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- W4309785961 endingPage "14430" @default.
- W4309785961 startingPage "14430" @default.
- W4309785961 abstract "Sleep apnea (SA) is a very prevalent sleep breathing disorder mainly characterized by intermittent hypoxemia and sleep fragmentation, with ensuing systemic inflammation, oxidative stress, and immune deregulation. These perturbations promote the risk of end-organ morbidity, such that SA patients are at increased risk of cardiovascular, neurocognitive, metabolic and malignant disorders. Investigating the potential mechanisms underlying SA-induced end-organ dysfunction requires the use of comprehensive experimental models at the cell, animal and human levels. This review is primarily focused on the experimental models employed to date in the study of the consequences of SA and tackles 3 different approaches. First, cell culture systems whereby controlled patterns of intermittent hypoxia cycling fast enough to mimic the rates of episodic hypoxemia experienced by patients with SA. Second, animal models consisting of implementing realistic upper airway obstruction patterns, intermittent hypoxia, or sleep fragmentation such as to reproduce the noxious events characterizing SA. Finally, human SA models, which consist either in subjecting healthy volunteers to intermittent hypoxia or sleep fragmentation, or alternatively applying oxygen supplementation or temporary nasal pressure therapy withdrawal to SA patients. The advantages, limitations, and potential improvements of these models along with some of their pertinent findings are reviewed." @default.
- W4309785961 created "2022-11-29" @default.
- W4309785961 creator A5011481509 @default.
- W4309785961 creator A5028348554 @default.
- W4309785961 creator A5067862560 @default.
- W4309785961 creator A5079996061 @default.
- W4309785961 date "2022-11-20" @default.
- W4309785961 modified "2023-10-17" @default.
- W4309785961 title "Experimental Models to Study End-Organ Morbidity in Sleep Apnea: Lessons Learned and Future Directions" @default.
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