FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309787620> ?p ?o ?g. }

• W4309787620 endingPage "14401" @default.
• W4309787620 startingPage "14401" @default.
• W4309787620 abstract "A new series of quinoxaline derivatives, 2a-4b, were synthesized and their anxiolytic potential was evaluated in vivo using elevated plus maze (EPM), open field (OF) and light-dark box (LDB) techniques. According to the results of the EPM, four active compounds were found in 2a, 2b, 2c, 4b. Their anxiolytic properties were confirmed in terms of LDB and the most active was compound 2b. In the OF, only 2c had an influence on the locomotor activity of the rodents. Thus, the most promising substance was determined; this was 2b, which has the structure of 2-(2-{[3-(4-tert-butylphenyl)quinoxaline-2-yl]methyl}-4,5-dimethoxyphenyl)-N-methylethan-1-amine hydrochloride. The obtained data were analyzed with the pharmacophore feature prediction approach, which made it possible to compare the structures of the studied compounds with the reference drug diazepam, and to determine the contribution of pharmacophores to the manifestation of the activity under study. ADMET analysis was carried out for compound 2b and the acute oral toxicity of this substance was also tested in vivo. As a result of the study, a promising compound with a high anxiolytic effect and low level of toxicity 2b was found, which is of interest for further preclinical study of its properties." @default.
• W4309787620 created "2022-11-29" @default.
• W4309787620 creator A5001003477 @default.
• W4309787620 creator A5002222183 @default.
• W4309787620 creator A5006726780 @default.
• W4309787620 creator A5006738030 @default.
• W4309787620 creator A5012345016 @default.
• W4309787620 creator A5019922273 @default.
• W4309787620 creator A5030959893 @default.
• W4309787620 creator A5036422721 @default.
• W4309787620 creator A5057431562 @default.
• W4309787620 creator A5080343056 @default.
• W4309787620 creator A5088176797 @default.
• W4309787620 creator A5091611559 @default.
• W4309787620 date "2022-11-19" @default.
• W4309787620 modified "2023-10-16" @default.
• W4309787620 title "Design, Synthesis and Pharmacological Evaluation of Novel C2,C3-Quinoxaline Derivatives as Promising Anxiolytic Agents" @default.
• W4309787620 cites W1790118405 @default.
• W4309787620 cites W1966332104 @default.
• W4309787620 cites W1971849220 @default.
• W4309787620 cites W1976924995 @default.
• W4309787620 cites W1978155128 @default.
• W4309787620 cites W2000397010 @default.
• W4309787620 cites W2009867031 @default.
• W4309787620 cites W2014858249 @default.
• W4309787620 cites W2025500109 @default.
• W4309787620 cites W2041388184 @default.
• W4309787620 cites W2048408953 @default.
• W4309787620 cites W2116326578 @default.
• W4309787620 cites W2153592313 @default.
• W4309787620 cites W2313174180 @default.
• W4309787620 cites W2336146742 @default.
• W4309787620 cites W2421391791 @default.
• W4309787620 cites W2494749460 @default.
• W4309787620 cites W2558293264 @default.
• W4309787620 cites W2584050883 @default.
• W4309787620 cites W2593436234 @default.
• W4309787620 cites W2610696603 @default.
• W4309787620 cites W2767910641 @default.
• W4309787620 cites W2801079377 @default.
• W4309787620 cites W2801088198 @default.
• W4309787620 cites W2805295723 @default.
• W4309787620 cites W2809035586 @default.
• W4309787620 cites W2905365975 @default.
• W4309787620 cites W2913614159 @default.
• W4309787620 cites W2939263684 @default.
• W4309787620 cites W2972243545 @default.
• W4309787620 cites W2976761635 @default.
• W4309787620 cites W3000673040 @default.
• W4309787620 cites W3004264679 @default.
• W4309787620 cites W3007213687 @default.
• W4309787620 cites W3011798246 @default.
• W4309787620 cites W3016269721 @default.
• W4309787620 cites W3020701801 @default.
• W4309787620 cites W3024535011 @default.
• W4309787620 cites W3033438882 @default.
• W4309787620 cites W3066127083 @default.
• W4309787620 cites W3172390218 @default.
• W4309787620 cites W3190085981 @default.
• W4309787620 cites W3202510670 @default.
• W4309787620 cites W4225342212 @default.
• W4309787620 cites W4225463101 @default.
• W4309787620 cites W948082336 @default.
• W4309787620 doi "https://doi.org/10.3390/ijms232214401" @default.
• W4309787620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36430878" @default.
• W4309787620 hasPublicationYear "2022" @default.
• W4309787620 type Work @default.
• W4309787620 citedByCount "1" @default.
• W4309787620 countsByYear W43097876202023 @default.
• W4309787620 crossrefType "journal-article" @default.
• W4309787620 hasAuthorship W4309787620A5001003477 @default.
• W4309787620 hasAuthorship W4309787620A5002222183 @default.
• W4309787620 hasAuthorship W4309787620A5006726780 @default.
• W4309787620 hasAuthorship W4309787620A5006738030 @default.
• W4309787620 hasAuthorship W4309787620A5012345016 @default.
• W4309787620 hasAuthorship W4309787620A5019922273 @default.
• W4309787620 hasAuthorship W4309787620A5030959893 @default.
• W4309787620 hasAuthorship W4309787620A5036422721 @default.
• W4309787620 hasAuthorship W4309787620A5057431562 @default.
• W4309787620 hasAuthorship W4309787620A5080343056 @default.
• W4309787620 hasAuthorship W4309787620A5088176797 @default.
• W4309787620 hasAuthorship W4309787620A5091611559 @default.
• W4309787620 hasBestOaLocation W43097876201 @default.
• W4309787620 hasConcept C116263406 @default.
• W4309787620 hasConcept C118552586 @default.
• W4309787620 hasConcept C150903083 @default.
• W4309787620 hasConcept C170493617 @default.
• W4309787620 hasConcept C173586616 @default.
• W4309787620 hasConcept C178790620 @default.
• W4309787620 hasConcept C185592680 @default.
• W4309787620 hasConcept C207001950 @default.
• W4309787620 hasConcept C2776175493 @default.
• W4309787620 hasConcept C2776460385 @default.
• W4309787620 hasConcept C2777765862 @default.
• W4309787620 hasConcept C2779085643 @default.
• W4309787620 hasConcept C2780362310 @default.
• W4309787620 hasConcept C29730261 @default.
• W4309787620 hasConcept C55493867 @default.

• next