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• W4309787997 abstract "Background Ticks are the primary vectors of emerging and resurging pathogens of public health significance worldwide. Analyzing tick bacterial composition, diversity, and functionality across developmental stages and tissues is crucial for designing new strategies to control ticks and prevent tick-borne diseases. Materials and methods Here, we explored the microbial communities across the developmental timeline and in different tissues of the Gulf-Coast ticks ( Amblyomma maculatum ). Using a high-throughput sequencing approach, the influence of blood meal and Rickettsia parkeri , a spotted fever group rickettsiae infection in driving changes in microbiome composition, diversity, and functionality was determined. Results This study shows that the core microbiome of Am. maculatum comprises ten core bacterial genera. The genus Rickettsia, Francisella , and Candidatus_Midichloria are the key players, with positive interactions within each developmental stage and adult tick organ tested. Blood meal and Rickettsia parkeri led to an increase in the bacterial abundance in the tissues. According to functional analysis, the increase in bacterial numbers is positively correlated to highly abundant energy metabolism orthologs with blood meal. Correlation analysis identified an increase in OTUs identified as Candidatus Midichloria and a subsequent decrease in Francisella OTUs in Rickettsia parkeri infected tick stages and tissues. Results demonstrate the abundance of Rickettsia and Francisella predominate in the core microbiome of Am. maculatum , whereas Candidatus_Midichloria and Cutibacterium prevalence increase with R. parkeri-infection . Network analysis and functional annotation suggest that R. parkeri interacts positively with Candidatus_Midichloria and negatively with Francisella . Conclusion We conclude that tick-transmitted pathogens, such as R. parkeri establishes infection by interacting with the core microbiome of the tick vector." @default.
• W4309787997 created "2022-11-29" @default.
• W4309787997 creator A5034213324 @default.
• W4309787997 creator A5041796660 @default.
• W4309787997 creator A5068937201 @default.
• W4309787997 creator A5083589682 @default.
• W4309787997 date "2022-11-21" @default.
• W4309787997 modified "2023-10-18" @default.
• W4309787997 title "Hematophagy and tick-borne Rickettsial pathogen shape the microbial community structure and predicted functions within the tick vector, Amblyomma maculatum" @default.
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