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- W4309791341 abstract "Reactive oxygen species (ROS) have been implicated in multiple cellular processes, and an imbalance in redox homeostasis gives rise to diseases, therefore, reestablishing redox homeostasis is a way to cure. Here, copper-based metal-organic networks (Cu-MON) are generated by one-step reaction using anti-inflammatory and antioxidant baicalein as organic ligand and pro-angiogenic copper as metal ions. Phosphate buffered saline is required for triggering Cu-MON formation, and baicalein regulates the morphology and particle size of Cu-MON. Cu-MON are composed of Cu-baicalein complexes (82.08 wt%) and Cu3 (PO4 )2 ·3H2 O (17.92 wt%), thus exhibit a variable catalase-like activity against different H2 O2 levels due to the reversible change between Cu2+ /Cu1+ /Cu0 species. Intramuscular injection of Cu-MON significantly increases blood flow of ischemic limb in diabetic mice, enhances the relative activities of redox-related enzymes in ischemic muscle, thus effectively ameliorating the oxidative damage. Taken together, through moderate and dynamic precise homeostasis regulation of cells, Cu-MON can be an efficient therapeutic strategy for peripheral arterial disease with diabetic complications." @default.
- W4309791341 created "2022-11-29" @default.
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- W4309791341 date "2022-12-03" @default.
- W4309791341 modified "2023-10-15" @default.
- W4309791341 title "Redox Modulatory Cu(II)‐Baicalein Microflowers Prepared in One Step Effectively Promote Therapeutic Angiogenesis in Diabetic Mice" @default.
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- W4309791341 doi "https://doi.org/10.1002/adhm.202202010" @default.
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