FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309816161> ?p ?o ?g. }

• W4309816161 endingPage "2455" @default.
• W4309816161 startingPage "2455" @default.
• W4309816161 abstract "In comparison to other methods of detection, electrochemistry offers a number of major advantages that make it the superior choice. One of these advantages is the capacity to monitor a wide variety of molecules, as opposed to just those that oxidize or deplete, by modifying the electrodes' surface areas and changing the material that makes up the electrodes in order to provide selectivity toward the biomolecule that is of interest. For more than three decades, the method known as Fast Scan Cyclic Voltammetry (FSCV) has been regarded as the method of choice for assessing neurotransmitters in animal models both in vitro and in vivo. It is important to create a unique method for measuring neuropeptides and other biomolecules in order to make use of long-term implants that have been approved by the FDA, such as electrodes used in deep brain stimulation (DBS). This research focuses on the use of electrochemical methods to biological applications, such as Square Wave Voltammetry (SWV) and Cyclic Voltammetry (CV). These methods allow researchers to detect biomolecules with a greater degree of accuracy. We investigated a variety of electrical devices for monitoring and detecting neuropeptide Y (NPY) using SWV and CV. For the purpose of NPY detection, we made use of platinum microelectrodes in conjunction with SWV and CV. Research on neurotransmission makes frequent use of microelectrodes because of their small size, electrochemical characteristics, and compatibility with quick electrochemical processes. Due to the precision and specificity offered by electrochemical techniques, we were required to develop a real-time technique in order to quantify biomolecules that were transported into the artificial cerebrospinal fluid (aCSF). This technique included the use of CV and SWV, both of which are examples of techniques that fall under the real-time category. The idea behind using aptamer-modified microelectrodes with methylene blue (MB) as a redox probe for the detection of NPY by SWV and CV is that the oxidizing potentials recorded by SWV may be utilized to evaluate the probe. This is the logic behind the use of these aptamer-modified microelectrodes. In order to conduct the test, an aCSF with a pH of 7.4 was used. It was essential to investigate SWV in space and time at NPY adsorption potentials and watch as MB was oxidized. For the purpose of studying SWV using platinum microelectrodes, we analyzed NPY with an aptamer that has been modified with MB. As a result of the fact that we were able to see a stable signal of MB throughout the characterizations, we have come to the conclusion that the strategy that we are utilizing for the modification of the aptamer is an effective one. In addition to this, we were successful in measuring NPY in a range of concentrations through the MB signal observed in the SWV. During the measurement of NPY we were able to see a decrease in current seen in the electrochemical signal of MB as we augmented the concentration of the neuropeptide. This enabled us to do a calibration curve that will be utilized for further measurements." @default.
• W4309816161 created "2022-11-29" @default.
• W4309816161 creator A5013686264 @default.
• W4309816161 creator A5027442469 @default.
• W4309816161 creator A5033278817 @default.
• W4309816161 creator A5065722562 @default.
• W4309816161 date "2022-10-09" @default.
• W4309816161 modified "2023-09-26" @default.
• W4309816161 title "Measurement of Neuropeptide Y By Square Wave Voltammetry Using Aptamer-Modified Platinum Microelectrodes and Methylene Blue" @default.
• W4309816161 doi "https://doi.org/10.1149/ma2022-02632455mtgabs" @default.
• W4309816161 hasPublicationYear "2022" @default.
• W4309816161 type Work @default.
• W4309816161 citedByCount "0" @default.
• W4309816161 crossrefType "journal-article" @default.
• W4309816161 hasAuthorship W4309816161A5013686264 @default.
• W4309816161 hasAuthorship W4309816161A5027442469 @default.
• W4309816161 hasAuthorship W4309816161A5033278817 @default.
• W4309816161 hasAuthorship W4309816161A5065722562 @default.
• W4309816161 hasConcept C111670793 @default.
• W4309816161 hasConcept C113196181 @default.
• W4309816161 hasConcept C119599485 @default.
• W4309816161 hasConcept C127413603 @default.
• W4309816161 hasConcept C147789679 @default.
• W4309816161 hasConcept C160756335 @default.
• W4309816161 hasConcept C161790260 @default.
• W4309816161 hasConcept C165801399 @default.
• W4309816161 hasConcept C171250308 @default.
• W4309816161 hasConcept C17525397 @default.
• W4309816161 hasConcept C185592680 @default.
• W4309816161 hasConcept C192562407 @default.
• W4309816161 hasConcept C2777869211 @default.
• W4309816161 hasConcept C2779603750 @default.
• W4309816161 hasConcept C43617362 @default.
• W4309816161 hasConcept C49853544 @default.
• W4309816161 hasConcept C518104683 @default.
• W4309816161 hasConcept C52859227 @default.
• W4309816161 hasConcept C55493867 @default.
• W4309816161 hasConcept C95967509 @default.
• W4309816161 hasConcept C96352100 @default.
• W4309816161 hasConceptScore W4309816161C111670793 @default.
• W4309816161 hasConceptScore W4309816161C113196181 @default.
• W4309816161 hasConceptScore W4309816161C119599485 @default.
• W4309816161 hasConceptScore W4309816161C127413603 @default.
• W4309816161 hasConceptScore W4309816161C147789679 @default.
• W4309816161 hasConceptScore W4309816161C160756335 @default.
• W4309816161 hasConceptScore W4309816161C161790260 @default.
• W4309816161 hasConceptScore W4309816161C165801399 @default.
• W4309816161 hasConceptScore W4309816161C171250308 @default.
• W4309816161 hasConceptScore W4309816161C17525397 @default.
• W4309816161 hasConceptScore W4309816161C185592680 @default.
• W4309816161 hasConceptScore W4309816161C192562407 @default.
• W4309816161 hasConceptScore W4309816161C2777869211 @default.
• W4309816161 hasConceptScore W4309816161C2779603750 @default.
• W4309816161 hasConceptScore W4309816161C43617362 @default.
• W4309816161 hasConceptScore W4309816161C49853544 @default.
• W4309816161 hasConceptScore W4309816161C518104683 @default.
• W4309816161 hasConceptScore W4309816161C52859227 @default.
• W4309816161 hasConceptScore W4309816161C55493867 @default.
• W4309816161 hasConceptScore W4309816161C95967509 @default.
• W4309816161 hasConceptScore W4309816161C96352100 @default.
• W4309816161 hasIssue "63" @default.
• W4309816161 hasLocation W43098161611 @default.
• W4309816161 hasOpenAccess W4309816161 @default.
• W4309816161 hasPrimaryLocation W43098161611 @default.
• W4309816161 hasRelatedWork W1969933858 @default.
• W4309816161 hasRelatedWork W1987953357 @default.
• W4309816161 hasRelatedWork W2013451123 @default.
• W4309816161 hasRelatedWork W2368981901 @default.
• W4309816161 hasRelatedWork W2376761276 @default.
• W4309816161 hasRelatedWork W2442029984 @default.
• W4309816161 hasRelatedWork W4309816161 @default.
• W4309816161 hasRelatedWork W4316362747 @default.
• W4309816161 hasRelatedWork W1736029541 @default.
• W4309816161 hasRelatedWork W2512456711 @default.
• W4309816161 hasVolume "MA2022-02" @default.
• W4309816161 isParatext "false" @default.
• W4309816161 isRetracted "false" @default.
• W4309816161 workType "article" @default.