FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309822152> ?p ?o ?g. }

• W4309822152 endingPage "e067447" @default.
• W4309822152 startingPage "e067447" @default.
• W4309822152 abstract "Introduction Major depressive disorder (MDD) represents a worldwide burden on healthcare and the response to antidepressants remains limited. Systems biology approaches have been used to explore the precision therapy. However, no reliable biomarker clinically exists for prognostic prediction at present. The objectives of the I ntegrated Module of M ultidimensional O mics for Pe r ipheral Biomark e rs (iMORE) study are to predict the efficacy of antidepressants by integrating multidimensional omics and performing validation in a real-world setting. As secondary aims, a series of potential biomarkers are explored for biological subtypes. Methods and analysis iMore is an observational cohort study in patients with MDD with a multistage design in China. The study is performed by three mental health centres comprising an observation phase and a validation phase. A total of 200 patients with MDD and 100 healthy controls were enrolled. The protocol-specified antidepressants are selective serotonin reuptake inhibitors and serotonin–norepinephrine reuptake inhibitors. Clinical visits (baseline, 4 and 8 weeks) include psychiatric rating scales for symptom assessment and biospecimen collection for multiomics analysis. Participants are divided into responders and non-responders based on treatment response (>50% reduction in Montgomery-Asberg Depression Rating Scale). Antidepressants’ responses are predicted and biomarkers are explored using supervised learning approach by integration of metabolites, cytokines, gut microbiomes and immunophenotypic cells. The accuracy of the prediction models constructed is verified in an independent validation phase. Ethics and dissemination The study was approved by the ethics committee of Shanghai Mental Health Center (approval number 2020-87). All participants need to sign a written consent for the study entry. Study findings will be published in peer-reviewed journals. Trial registration number NCT04518592 ." @default.
• W4309822152 created "2022-11-29" @default.
• W4309822152 creator A5016044907 @default.
• W4309822152 creator A5017947172 @default.
• W4309822152 creator A5022187718 @default.
• W4309822152 creator A5023015562 @default.
• W4309822152 creator A5025056261 @default.
• W4309822152 creator A5029683591 @default.
• W4309822152 creator A5031690451 @default.
• W4309822152 creator A5033602621 @default.
• W4309822152 creator A5044479589 @default.
• W4309822152 date "2022-11-01" @default.
• W4309822152 modified "2023-09-26" @default.
• W4309822152 title "Integrated Module of Multidimensional Omics for Peripheral Biomarkers (iMORE) in patients with major depressive disorder: rationale and design of a prospective multicentre cohort study" @default.
• W4309822152 cites W1835690719 @default.
• W4309822152 cites W1977804070 @default.
• W4309822152 cites W1985438873 @default.
• W4309822152 cites W1988690727 @default.
• W4309822152 cites W1999142409 @default.
• W4309822152 cites W2003982930 @default.
• W4309822152 cites W2007217939 @default.
• W4309822152 cites W2015700432 @default.
• W4309822152 cites W2020521134 @default.
• W4309822152 cites W2039056175 @default.
• W4309822152 cites W2042944469 @default.
• W4309822152 cites W2052055556 @default.
• W4309822152 cites W2058494291 @default.
• W4309822152 cites W2078529968 @default.
• W4309822152 cites W2084415324 @default.
• W4309822152 cites W2097572674 @default.
• W4309822152 cites W2100495367 @default.
• W4309822152 cites W2114058973 @default.
• W4309822152 cites W2128529684 @default.
• W4309822152 cites W2132324173 @default.
• W4309822152 cites W2148337554 @default.
• W4309822152 cites W2149402043 @default.
• W4309822152 cites W2162510673 @default.
• W4309822152 cites W2257438637 @default.
• W4309822152 cites W2287782000 @default.
• W4309822152 cites W2320854008 @default.
• W4309822152 cites W2398143306 @default.
• W4309822152 cites W2547425734 @default.
• W4309822152 cites W2614538492 @default.
• W4309822152 cites W2618672386 @default.
• W4309822152 cites W2737966001 @default.
• W4309822152 cites W2753966476 @default.
• W4309822152 cites W2760767555 @default.
• W4309822152 cites W2766190419 @default.
• W4309822152 cites W2788337440 @default.
• W4309822152 cites W2792485919 @default.
• W4309822152 cites W2810177850 @default.
• W4309822152 cites W2812177042 @default.
• W4309822152 cites W2892587974 @default.
• W4309822152 cites W2898429525 @default.
• W4309822152 cites W2900590734 @default.
• W4309822152 cites W2908242089 @default.
• W4309822152 cites W2919454412 @default.
• W4309822152 cites W2920331744 @default.
• W4309822152 cites W2921793675 @default.
• W4309822152 cites W2931211518 @default.
• W4309822152 cites W2931770513 @default.
• W4309822152 cites W2940360720 @default.
• W4309822152 cites W2941936861 @default.
• W4309822152 cites W2949520255 @default.
• W4309822152 cites W2955026049 @default.
• W4309822152 cites W2955502047 @default.
• W4309822152 cites W2959539918 @default.
• W4309822152 cites W2979390143 @default.
• W4309822152 cites W2980328141 @default.
• W4309822152 cites W2995725664 @default.
• W4309822152 cites W2996749452 @default.
• W4309822152 cites W3003314402 @default.
• W4309822152 cites W3005056829 @default.
• W4309822152 cites W3010662401 @default.
• W4309822152 cites W3011727813 @default.
• W4309822152 cites W3045779896 @default.
• W4309822152 cites W3092849554 @default.
• W4309822152 cites W3097088286 @default.
• W4309822152 cites W3106107172 @default.
• W4309822152 cites W3121356225 @default.
• W4309822152 cites W3156448172 @default.
• W4309822152 cites W3175172862 @default.
• W4309822152 cites W3203904019 @default.
• W4309822152 cites W3205792946 @default.
• W4309822152 cites W3213224786 @default.
• W4309822152 cites W4200354658 @default.
• W4309822152 cites W4206939341 @default.
• W4309822152 cites W4214898380 @default.
• W4309822152 cites W4225554953 @default.
• W4309822152 cites W4231169313 @default.
• W4309822152 cites W4292335446 @default.
• W4309822152 cites W4297546027 @default.
• W4309822152 doi "https://doi.org/10.1136/bmjopen-2022-067447" @default.
• W4309822152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36418119" @default.
• W4309822152 hasPublicationYear "2022" @default.
• W4309822152 type Work @default.
• W4309822152 citedByCount "0" @default.
• W4309822152 crossrefType "journal-article" @default.

• next