Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309834843> ?p ?o ?g. }
- W4309834843 abstract "Introduction Mucosal-associated invariant T (MAIT) cells might play a role in B cell hyperactivity and local inflammation in primary Sjögren’s syndrome (pSS), just like previously studied mucosa-associated CCR9+ and CXCR5+ T helper cells. Here, we investigated expression of CCR9, CXCR5, IL-18R and IL-7R on MAIT cells in pSS, and assessed the capacity of DMARDs to inhibit the activity of MAIT cells. Methods Circulating CD161+ and IL-18Rα+ TCRVα7.2+ MAIT cells from pSS patients and healthy controls (HC) were assessed using flow cytometry, and expression of CCR9, CXCR5, and IL-7R on MAIT cells was studied. Production of IFN-γ and IL-21 by MAIT cells was measured upon IL-7 stimulation in the presence of leflunomide (LEF) and hydroxychloroquine (HCQ). Results The numbers of CD161+ and IL-18Rα+ MAIT cells were decreased in pSS patients compared to HC. Relative increased percentages of CD4 MAIT cells in pSS patients caused significantly higher CD4/CD8 ratios in MAIT cells. The numbers of CCR9 and CXCR5-expressing MAIT cells were significantly higher in pSS patients. IL-7R expression was higher in CD8 MAIT cells as compared to all CD8 T cells, and changes in IL-7R expression correlated to several clinical parameters. The elevated production of IL-21 by MAIT cells was significantly inhibited by LEF/HCQ treatment. Conclusion Circulating CD161+ and IL-18Rα+ MAIT cell numbers are decreased in pSS patients. Given their enriched CCR9/CXCR5 expression this may facilitate migration to inflamed salivary glands known to overexpress CCL25/CXCL13. Given the pivotal role of IL-7 and IL-21 in inflammation in pSS this indicates a potential role for MAIT cells in driving pSS immunopathology." @default.
- W4309834843 created "2022-11-29" @default.
- W4309834843 creator A5006690451 @default.
- W4309834843 creator A5008745115 @default.
- W4309834843 creator A5082719938 @default.
- W4309834843 creator A5090141719 @default.
- W4309834843 date "2022-11-24" @default.
- W4309834843 modified "2023-09-26" @default.
- W4309834843 title "In patients with primary Sjögren’s syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells" @default.
- W4309834843 cites W1538607209 @default.
- W4309834843 cites W1624230893 @default.
- W4309834843 cites W1748698773 @default.
- W4309834843 cites W1919305622 @default.
- W4309834843 cites W1935043882 @default.
- W4309834843 cites W1973533990 @default.
- W4309834843 cites W1977200683 @default.
- W4309834843 cites W1981700081 @default.
- W4309834843 cites W1984582719 @default.
- W4309834843 cites W1987742631 @default.
- W4309834843 cites W1989617933 @default.
- W4309834843 cites W2001775594 @default.
- W4309834843 cites W2002011103 @default.
- W4309834843 cites W2002641565 @default.
- W4309834843 cites W2009603759 @default.
- W4309834843 cites W2027160668 @default.
- W4309834843 cites W2055889057 @default.
- W4309834843 cites W2057859305 @default.
- W4309834843 cites W2060533920 @default.
- W4309834843 cites W2062121752 @default.
- W4309834843 cites W2065252029 @default.
- W4309834843 cites W2065669145 @default.
- W4309834843 cites W2073247934 @default.
- W4309834843 cites W2098258181 @default.
- W4309834843 cites W2104961731 @default.
- W4309834843 cites W2106095589 @default.
- W4309834843 cites W2123634464 @default.
- W4309834843 cites W2138879607 @default.
- W4309834843 cites W2143730020 @default.
- W4309834843 cites W2144768135 @default.
- W4309834843 cites W2160501643 @default.
- W4309834843 cites W2169416095 @default.
- W4309834843 cites W2464020216 @default.
- W4309834843 cites W2515441427 @default.
- W4309834843 cites W2516923000 @default.
- W4309834843 cites W2557919284 @default.
- W4309834843 cites W2596531042 @default.
- W4309834843 cites W2617447744 @default.
- W4309834843 cites W2625765212 @default.
- W4309834843 cites W266228586 @default.
- W4309834843 cites W2746191652 @default.
- W4309834843 cites W2748143379 @default.
- W4309834843 cites W2786928529 @default.
- W4309834843 cites W2787662649 @default.
- W4309834843 cites W2790170256 @default.
- W4309834843 cites W2793352806 @default.
- W4309834843 cites W2807445234 @default.
- W4309834843 cites W2898954851 @default.
- W4309834843 cites W2909486078 @default.
- W4309834843 cites W2920994621 @default.
- W4309834843 cites W2950205388 @default.
- W4309834843 cites W2990981263 @default.
- W4309834843 cites W2994994537 @default.
- W4309834843 cites W3013945520 @default.
- W4309834843 cites W3022289262 @default.
- W4309834843 cites W3089041431 @default.
- W4309834843 cites W3093392005 @default.
- W4309834843 cites W3127852620 @default.
- W4309834843 cites W3135344796 @default.
- W4309834843 cites W3138950666 @default.
- W4309834843 cites W3183244337 @default.
- W4309834843 cites W4206142072 @default.
- W4309834843 cites W4211082175 @default.
- W4309834843 cites W4214879111 @default.
- W4309834843 cites W4223439572 @default.
- W4309834843 cites W4281627405 @default.
- W4309834843 doi "https://doi.org/10.3389/fimmu.2022.1017157" @default.
- W4309834843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36505431" @default.
- W4309834843 hasPublicationYear "2022" @default.
- W4309834843 type Work @default.
- W4309834843 citedByCount "0" @default.
- W4309834843 crossrefType "journal-article" @default.
- W4309834843 hasAuthorship W4309834843A5006690451 @default.
- W4309834843 hasAuthorship W4309834843A5008745115 @default.
- W4309834843 hasAuthorship W4309834843A5082719938 @default.
- W4309834843 hasAuthorship W4309834843A5090141719 @default.
- W4309834843 hasBestOaLocation W43098348431 @default.
- W4309834843 hasConcept C126322002 @default.
- W4309834843 hasConcept C12823836 @default.
- W4309834843 hasConcept C13373296 @default.
- W4309834843 hasConcept C167672396 @default.
- W4309834843 hasConcept C185592680 @default.
- W4309834843 hasConcept C203014093 @default.
- W4309834843 hasConcept C2776708503 @default.
- W4309834843 hasConcept C2776914184 @default.
- W4309834843 hasConcept C2779123688 @default.
- W4309834843 hasConcept C2779134260 @default.
- W4309834843 hasConcept C3008058167 @default.
- W4309834843 hasConcept C47348012 @default.
- W4309834843 hasConcept C524204448 @default.
- W4309834843 hasConcept C553184892 @default.