FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309845725> ?p ?o ?g. }

• W4309845725 endingPage "3737" @default.
• W4309845725 startingPage "3737" @default.
• W4309845725 abstract "Background: Long non-coding RNAs have been reported to be involved in tumorigenesis and progression through different regulatory mechanisms. It has been reported that aberrantly expressed long non-coding RNA LINC00491 promotes malignancy in multiple tumors, while the role of LINC00491 in lung adenocarcinoma (LUAD) is little reported and the mechanism for regulating tumor progression has not been elucidated. Methods: RNA sequencing and the TCGA database were combined to screen differentially expressed lncRNAs that facilitate tumor progression. The expression level of LINC00491 was examined in LUAD clinical samples and in cell lines using RT-qPCR. In vitro experiments including colony formation assay, EdU assay, cell migration and invasion assay and wound healing assay, and in vivo experiments including xenografting subcutaneous tumors and lung metastasis models were performed to investigate the function of LINC00491 in LUAD tumor progressions. RNA pull-down, mass spectrometry, RIP assays and truncation experiments were carried out to explore the proteins binding to LINC00491 and the specific interactions between the RNA-protein complex. Results: Our results showed that LINC0491 was significantly upregulated in LUAD and positively correlated with poor survival. High LINC00491 expression promoted proliferation, migration and invasion, and resulted in a high metastatic burden in LUAD. Using pull-down assay and mass spectrometry, MTSS1 was found binding to LINC00491, and the conducted experiments verified the direct interaction between LINC00491 and MTSS1. Meanwhile, LINC00491 was found to regulate MTSS1 degradation by promoting the MTSS1 ubiquitination level and then activating the Wnt/β-catenin-signaling pathway. LINC00491/MTSS1/β-catenin may act as a complex to facilitate tumor progression. Conclusions: In summary, our results found a novel mechanism in which LINC00491 directly interacts with MTSS1 by affecting its ubiquitination modification to promote LUAD proliferation, migration and invasion, then activating the Wnt/β-catenin-signaling pathway, demonstrating its significant role in tumor progression and suggesting that the LINC00491/MTSS1/Wnt/β-catenin-signaling pathway could serve as a potential therapeutic target for lung adenocarcinoma in the future." @default.
• W4309845725 created "2022-11-29" @default.
• W4309845725 creator A5002383411 @default.
• W4309845725 creator A5013693577 @default.
• W4309845725 creator A5052144779 @default.
• W4309845725 creator A5067882671 @default.
• W4309845725 creator A5085677214 @default.
• W4309845725 date "2022-11-23" @default.
• W4309845725 modified "2023-10-03" @default.
• W4309845725 title "LINC00491 Facilitates Tumor Progression of Lung Adenocarcinoma via Wnt/β-Catenin-Signaling Pathway by Regulating MTSS1 Ubiquitination" @default.
• W4309845725 cites W1964079416 @default.
• W4309845725 cites W1974009908 @default.
• W4309845725 cites W2048675800 @default.
• W4309845725 cites W2050982262 @default.
• W4309845725 cites W2128685361 @default.
• W4309845725 cites W2128775512 @default.
• W4309845725 cites W2139241465 @default.
• W4309845725 cites W2154671690 @default.
• W4309845725 cites W2158626602 @default.
• W4309845725 cites W2395465815 @default.
• W4309845725 cites W2416907124 @default.
• W4309845725 cites W2508069933 @default.
• W4309845725 cites W2570436295 @default.
• W4309845725 cites W2594394947 @default.
• W4309845725 cites W2625043156 @default.
• W4309845725 cites W2735265951 @default.
• W4309845725 cites W2772509388 @default.
• W4309845725 cites W2779372229 @default.
• W4309845725 cites W2920912903 @default.
• W4309845725 cites W2965299749 @default.
• W4309845725 cites W2980862799 @default.
• W4309845725 cites W3001391964 @default.
• W4309845725 cites W3006896848 @default.
• W4309845725 cites W3007690595 @default.
• W4309845725 cites W3009922854 @default.
• W4309845725 cites W3026882918 @default.
• W4309845725 cites W3049152128 @default.
• W4309845725 cites W3097117463 @default.
• W4309845725 cites W3115880421 @default.
• W4309845725 cites W3119005666 @default.
• W4309845725 cites W3126928460 @default.
• W4309845725 cites W3128646645 @default.
• W4309845725 cites W3135336434 @default.
• W4309845725 cites W3136436577 @default.
• W4309845725 cites W3158564029 @default.
• W4309845725 cites W3158807108 @default.
• W4309845725 cites W3212457986 @default.
• W4309845725 cites W4221092903 @default.
• W4309845725 cites W4283031510 @default.
• W4309845725 cites W4283701080 @default.
• W4309845725 cites W4290467000 @default.
• W4309845725 cites W4292348655 @default.
• W4309845725 doi "https://doi.org/10.3390/cells11233737" @default.
• W4309845725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36496997" @default.
• W4309845725 hasPublicationYear "2022" @default.
• W4309845725 type Work @default.
• W4309845725 citedByCount "1" @default.
• W4309845725 countsByYear W43098457252023 @default.
• W4309845725 crossrefType "journal-article" @default.
• W4309845725 hasAuthorship W4309845725A5002383411 @default.
• W4309845725 hasAuthorship W4309845725A5013693577 @default.
• W4309845725 hasAuthorship W4309845725A5052144779 @default.
• W4309845725 hasAuthorship W4309845725A5067882671 @default.
• W4309845725 hasAuthorship W4309845725A5085677214 @default.
• W4309845725 hasBestOaLocation W43098457251 @default.
• W4309845725 hasConcept C104317684 @default.
• W4309845725 hasConcept C121608353 @default.
• W4309845725 hasConcept C127561419 @default.
• W4309845725 hasConcept C137620995 @default.
• W4309845725 hasConcept C2779013556 @default.
• W4309845725 hasConcept C2779256057 @default.
• W4309845725 hasConcept C2781182431 @default.
• W4309845725 hasConcept C30145163 @default.
• W4309845725 hasConcept C502942594 @default.
• W4309845725 hasConcept C54355233 @default.
• W4309845725 hasConcept C555283112 @default.
• W4309845725 hasConcept C62203573 @default.
• W4309845725 hasConcept C62478195 @default.
• W4309845725 hasConcept C67705224 @default.
• W4309845725 hasConcept C86803240 @default.
• W4309845725 hasConcept C95444343 @default.
• W4309845725 hasConceptScore W4309845725C104317684 @default.
• W4309845725 hasConceptScore W4309845725C121608353 @default.
• W4309845725 hasConceptScore W4309845725C127561419 @default.
• W4309845725 hasConceptScore W4309845725C137620995 @default.
• W4309845725 hasConceptScore W4309845725C2779013556 @default.
• W4309845725 hasConceptScore W4309845725C2779256057 @default.
• W4309845725 hasConceptScore W4309845725C2781182431 @default.
• W4309845725 hasConceptScore W4309845725C30145163 @default.
• W4309845725 hasConceptScore W4309845725C502942594 @default.
• W4309845725 hasConceptScore W4309845725C54355233 @default.
• W4309845725 hasConceptScore W4309845725C555283112 @default.
• W4309845725 hasConceptScore W4309845725C62203573 @default.
• W4309845725 hasConceptScore W4309845725C62478195 @default.
• W4309845725 hasConceptScore W4309845725C67705224 @default.
• W4309845725 hasConceptScore W4309845725C86803240 @default.
• W4309845725 hasConceptScore W4309845725C95444343 @default.
• W4309845725 hasFunder F4320321001 @default.

• next