FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309845983> ?p ?o ?g. }

• W4309845983 abstract "Shiga toxin-producing Escherichia coli (STEC) O121 is among the top six non-O157 serogroups that are most frequently associated with severe disease in humans. While O121:H19 is predominant, other O121 serotypes have been frequently isolated from environmental samples, but their virulence repertoire is poorly characterized. Here, we sequenced the complete genomes of two animal isolates belonging to O121:H7 and O121:H10 and performed comparative genomic analysis with O121:H19 to assess their virulence potential. Both O121:H7 and O121:H10 strains carry a genome comparable in size with the O121:H19 genomes and belong to phylogroup B1. However, both strains appear to have evolved from a different lineage than the O121:H19 strains according to the core genes-based phylogeny and Multi Locus Sequence Typing. A systematic search of over 300 E. coli virulence genes listed in the Virulence Factor DataBase revealed a total of 73 and 71 in O121:H7 and O121:H10 strains, respectively, in comparison with an average of 135 in the O121:H19 strains. This variation in the virulence genes repertoire was mainly attributed to the reduction in the number of genes related to the Type III Secretion System in the O121:H7 and O121:H10 strains. Compared to the O121:H19 strains, the O121:H7 strain carries more adherence and toxin genes while the O121:H10 strain carries more genes related to the Type VI Secretion System. Although both O121:H7 and O121:H10 strains carry the large virulence plasmid pEHEC, they do not harbor all pEHEC virulence genes in O121:H19. Furthermore, unlike the O121:H19 strains, neither the O121:H7 nor O121:H10 strain carried the Locus of Enterocyte Effacement, OI-122, nor the tellurite resistance island. Although an incomplete Locus of Adhesion and Autoaggregation (LAA) was identified in the O121:H7 and O121:H10 strains, a limited number of virulence genes were present. Consistently, both O121:H7 and O121:H10 strains displayed significant reduced cytotoxicity than either the O157:H7 strain EDL933 or the O121:H19 strain RM8352. In fact, the O121:H7 strain RM8082 appeared to cause minimal cytotoxicity to Vero cells. Our study demonstrated distinct evolutionary lineages among the strains of serotypes O121:H19, O121:H10, and O121:H7 and suggested reduced virulence potentials in STEC strains of O121:H10 and O121:H7." @default.
• W4309845983 created "2022-11-29" @default.
• W4309845983 creator A5026450662 @default.
• W4309845983 creator A5069528440 @default.
• W4309845983 creator A5072291621 @default.
• W4309845983 creator A5089136767 @default.
• W4309845983 date "2022-11-24" @default.
• W4309845983 modified "2023-10-05" @default.
• W4309845983 title "Comparative genomic and phenotypic analyses of the virulence potential in Shiga toxin-producing Escherichia coli O121:H7 and O121:H10" @default.
• W4309845983 cites W18798068 @default.
• W4309845983 cites W1897609666 @default.
• W4309845983 cites W1958765529 @default.
• W4309845983 cites W1976852236 @default.
• W4309845983 cites W1985317246 @default.
• W4309845983 cites W1991894713 @default.
• W4309845983 cites W1993562792 @default.
• W4309845983 cites W1997729740 @default.
• W4309845983 cites W2011610047 @default.
• W4309845983 cites W2045765967 @default.
• W4309845983 cites W2051976405 @default.
• W4309845983 cites W2056016766 @default.
• W4309845983 cites W2060587237 @default.
• W4309845983 cites W2069115445 @default.
• W4309845983 cites W2080521361 @default.
• W4309845983 cites W2085468778 @default.
• W4309845983 cites W2090446629 @default.
• W4309845983 cites W2098712910 @default.
• W4309845983 cites W2102706796 @default.
• W4309845983 cites W2107015455 @default.
• W4309845983 cites W2107225159 @default.
• W4309845983 cites W2110108384 @default.
• W4309845983 cites W2112111992 @default.
• W4309845983 cites W2113493287 @default.
• W4309845983 cites W2121639492 @default.
• W4309845983 cites W2121841330 @default.
• W4309845983 cites W2122095711 @default.
• W4309845983 cites W2122597340 @default.
• W4309845983 cites W2125774503 @default.
• W4309845983 cites W2130668158 @default.
• W4309845983 cites W2130953063 @default.
• W4309845983 cites W2134153749 @default.
• W4309845983 cites W2134819521 @default.
• W4309845983 cites W2136379364 @default.
• W4309845983 cites W2137808700 @default.
• W4309845983 cites W2141255185 @default.
• W4309845983 cites W2142402047 @default.
• W4309845983 cites W2144680526 @default.
• W4309845983 cites W2152019335 @default.
• W4309845983 cites W2152261560 @default.
• W4309845983 cites W2152591548 @default.
• W4309845983 cites W2154120253 @default.
• W4309845983 cites W2157612734 @default.
• W4309845983 cites W2158277438 @default.
• W4309845983 cites W2159153498 @default.
• W4309845983 cites W2161060487 @default.
• W4309845983 cites W2162740809 @default.
• W4309845983 cites W2170555862 @default.
• W4309845983 cites W2281368702 @default.
• W4309845983 cites W2310042756 @default.
• W4309845983 cites W2329272538 @default.
• W4309845983 cites W2335901076 @default.
• W4309845983 cites W2340588612 @default.
• W4309845983 cites W2341787842 @default.
• W4309845983 cites W2345791363 @default.
• W4309845983 cites W2430272488 @default.
• W4309845983 cites W2551619186 @default.
• W4309845983 cites W2568161531 @default.
• W4309845983 cites W2610656577 @default.
• W4309845983 cites W2734064311 @default.
• W4309845983 cites W2736341152 @default.
• W4309845983 cites W2765535974 @default.
• W4309845983 cites W2767133938 @default.
• W4309845983 cites W2769310246 @default.
• W4309845983 cites W2784628271 @default.
• W4309845983 cites W2794874331 @default.
• W4309845983 cites W2801402983 @default.
• W4309845983 cites W2803829912 @default.
• W4309845983 cites W2824458099 @default.
• W4309845983 cites W2902206381 @default.
• W4309845983 cites W2921814281 @default.
• W4309845983 cites W2935451769 @default.
• W4309845983 cites W2968877993 @default.
• W4309845983 cites W2993005136 @default.
• W4309845983 cites W3003375248 @default.
• W4309845983 cites W3033338597 @default.
• W4309845983 cites W3034135953 @default.
• W4309845983 cites W3127813315 @default.
• W4309845983 cites W3162058474 @default.
• W4309845983 cites W3174287158 @default.
• W4309845983 cites W4224324685 @default.
• W4309845983 cites W4200209547 @default.
• W4309845983 doi "https://doi.org/10.3389/fcimb.2022.1043726" @default.
• W4309845983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36506028" @default.
• W4309845983 hasPublicationYear "2022" @default.
• W4309845983 type Work @default.
• W4309845983 citedByCount "2" @default.
• W4309845983 countsByYear W43098459832023 @default.
• W4309845983 crossrefType "journal-article" @default.
• W4309845983 hasAuthorship W4309845983A5026450662 @default.
• W4309845983 hasAuthorship W4309845983A5069528440 @default.

• next