Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309848249> ?p ?o ?g. }
- W4309848249 endingPage "4973" @default.
- W4309848249 startingPage "4973" @default.
- W4309848249 abstract "Dysfunctions in liver metabolic activities may increase the risk of cognitive impairment and dementia. In a cohort of community-dwelling older persons investigated for a suspected cognitive decline, we studied the association between liver status and dementia, considering sex and frailty contribution. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentrations, and the AST/ALT ratio were used to assess liver function in 419 older adults (248 persons with dementia and 171 age- and sex-matched subjects without cognitive decline). Although the serum concentrations of the liver enzymes were in the physiologic range, patients with dementia showed lower ALT concentrations (p = 0.005) and higher AST/ALT ratios (p = 0.003) compared to controls. The same differences were found when comparing men with and without dementia (ALT, p = 0.009; AST/ALT ratio, p = 0.003) but disappeared in women. Curiously, comparing women and men with the same diagnosis, the ALT concentrations were lower (p = 0.008), and the AST/ALT ratio was higher (p = 0.001) in control women than men, whereas no significant difference was found between persons with dementia. In conclusion, in our cohort of older people living in the community, the association between serum aminotransferases and dementia was remarked. Moreover, our results support attention to sex difference in liver function, suggesting a role in the pathogenesis of dementia." @default.
- W4309848249 created "2022-11-29" @default.
- W4309848249 creator A5027772153 @default.
- W4309848249 creator A5060300835 @default.
- W4309848249 creator A5069997894 @default.
- W4309848249 creator A5075363939 @default.
- W4309848249 creator A5088679411 @default.
- W4309848249 date "2022-11-23" @default.
- W4309848249 modified "2023-10-02" @default.
- W4309848249 title "Liver Enzymes in a Cohort of Community-Dwelling Older Persons: Focus on Sex Contribution" @default.
- W4309848249 cites W1858689059 @default.
- W4309848249 cites W1905529713 @default.
- W4309848249 cites W1981460639 @default.
- W4309848249 cites W1983126679 @default.
- W4309848249 cites W1992788998 @default.
- W4309848249 cites W1993662614 @default.
- W4309848249 cites W2000494728 @default.
- W4309848249 cites W2001474047 @default.
- W4309848249 cites W2015759096 @default.
- W4309848249 cites W2039394429 @default.
- W4309848249 cites W2043175458 @default.
- W4309848249 cites W2062192973 @default.
- W4309848249 cites W2076284721 @default.
- W4309848249 cites W2077318670 @default.
- W4309848249 cites W2091811130 @default.
- W4309848249 cites W2113870267 @default.
- W4309848249 cites W2116709840 @default.
- W4309848249 cites W2121962935 @default.
- W4309848249 cites W2123770204 @default.
- W4309848249 cites W2124841160 @default.
- W4309848249 cites W2133015203 @default.
- W4309848249 cites W2139520621 @default.
- W4309848249 cites W2147618479 @default.
- W4309848249 cites W2155658630 @default.
- W4309848249 cites W2158468809 @default.
- W4309848249 cites W2164186760 @default.
- W4309848249 cites W2166834388 @default.
- W4309848249 cites W2168489336 @default.
- W4309848249 cites W2200489097 @default.
- W4309848249 cites W2265176083 @default.
- W4309848249 cites W2286726515 @default.
- W4309848249 cites W2603228471 @default.
- W4309848249 cites W2657266655 @default.
- W4309848249 cites W2771493680 @default.
- W4309848249 cites W2791894605 @default.
- W4309848249 cites W2792809753 @default.
- W4309848249 cites W2808027779 @default.
- W4309848249 cites W2883625632 @default.
- W4309848249 cites W2885688677 @default.
- W4309848249 cites W2903488549 @default.
- W4309848249 cites W2913585733 @default.
- W4309848249 cites W2944852416 @default.
- W4309848249 cites W2959600071 @default.
- W4309848249 cites W2966029669 @default.
- W4309848249 cites W2966102363 @default.
- W4309848249 cites W2975638888 @default.
- W4309848249 cites W2979248397 @default.
- W4309848249 cites W2991033511 @default.
- W4309848249 cites W2997847443 @default.
- W4309848249 cites W3094334480 @default.
- W4309848249 cites W3119794053 @default.
- W4309848249 cites W3127341666 @default.
- W4309848249 cites W3205041012 @default.
- W4309848249 cites W4206055706 @default.
- W4309848249 cites W4220702740 @default.
- W4309848249 cites W4225986196 @default.
- W4309848249 cites W4247665917 @default.
- W4309848249 cites W49725469 @default.
- W4309848249 doi "https://doi.org/10.3390/nu14234973" @default.
- W4309848249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36501002" @default.
- W4309848249 hasPublicationYear "2022" @default.
- W4309848249 type Work @default.
- W4309848249 citedByCount "4" @default.
- W4309848249 countsByYear W43098482492023 @default.
- W4309848249 crossrefType "journal-article" @default.
- W4309848249 hasAuthorship W4309848249A5027772153 @default.
- W4309848249 hasAuthorship W4309848249A5060300835 @default.
- W4309848249 hasAuthorship W4309848249A5069997894 @default.
- W4309848249 hasAuthorship W4309848249A5075363939 @default.
- W4309848249 hasAuthorship W4309848249A5088679411 @default.
- W4309848249 hasBestOaLocation W43098482491 @default.
- W4309848249 hasConcept C126322002 @default.
- W4309848249 hasConcept C201903717 @default.
- W4309848249 hasConcept C2778606649 @default.
- W4309848249 hasConcept C2779134260 @default.
- W4309848249 hasConcept C2779483572 @default.
- W4309848249 hasConcept C2992872382 @default.
- W4309848249 hasConcept C71924100 @default.
- W4309848249 hasConcept C72563966 @default.
- W4309848249 hasConcept C74909509 @default.
- W4309848249 hasConcept C90924648 @default.
- W4309848249 hasConceptScore W4309848249C126322002 @default.
- W4309848249 hasConceptScore W4309848249C201903717 @default.
- W4309848249 hasConceptScore W4309848249C2778606649 @default.
- W4309848249 hasConceptScore W4309848249C2779134260 @default.
- W4309848249 hasConceptScore W4309848249C2779483572 @default.
- W4309848249 hasConceptScore W4309848249C2992872382 @default.
- W4309848249 hasConceptScore W4309848249C71924100 @default.