Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309848897> ?p ?o ?g. }
- W4309848897 endingPage "3750" @default.
- W4309848897 startingPage "3750" @default.
- W4309848897 abstract "Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) have emerged as novel tools in regenerative medicine. Angiogenesis modulation is widely studied for the treatment of ischaemic diseases, wound healing, and tissue regeneration. Here, we have shown that EVs from human umbilical cord-derived MSCs can affect VEGFR2 signalling, a master regulator of angiogenesis homeostasis, via altering the phosphorylation of AKT. This translates into an inhibition of apoptosis, promoting exclusively cell survival, but not proliferation, in human microvascular endothelial cells. Interestingly, when comparing EVs from normoxic cells to those obtained from hypoxia (1% O2) preconditioned cells, hypoxia-derived EVs appear to have a slightly enhanced effect. Furthermore, when studied in a longer term endothelial-fibroblast co-culture angiogenesis model in vitro, both EV populations demonstrated a positive effect on vessel formation, evidenced by increased vessel networks with tubes of significantly larger diameters. Our data reveals that EVs selectively target components of the angiogenic pathway, promoting VEGFR2-mediated cell survival via enhancement of AKT activation. Our data show that EVs are able to enhance specific components of the VEGF signalling pathway and may have therapeutic potential to support endothelial cell survival." @default.
- W4309848897 created "2022-11-29" @default.
- W4309848897 creator A5046706740 @default.
- W4309848897 creator A5066941082 @default.
- W4309848897 creator A5071145764 @default.
- W4309848897 creator A5089790546 @default.
- W4309848897 date "2022-11-24" @default.
- W4309848897 modified "2023-10-10" @default.
- W4309848897 title "Extracellular Vesicles from Human Umbilical Cord-Derived MSCs Affect Vessel Formation In Vitro and Promote VEGFR2-Mediated Cell Survival" @default.
- W4309848897 cites W1726025741 @default.
- W4309848897 cites W1877686344 @default.
- W4309848897 cites W1969832663 @default.
- W4309848897 cites W1973262582 @default.
- W4309848897 cites W1980969801 @default.
- W4309848897 cites W1985359220 @default.
- W4309848897 cites W1997508706 @default.
- W4309848897 cites W2006920813 @default.
- W4309848897 cites W2019147365 @default.
- W4309848897 cites W2038399651 @default.
- W4309848897 cites W2049097459 @default.
- W4309848897 cites W2066426973 @default.
- W4309848897 cites W2081128658 @default.
- W4309848897 cites W2082664513 @default.
- W4309848897 cites W2084693500 @default.
- W4309848897 cites W2085326091 @default.
- W4309848897 cites W2091774189 @default.
- W4309848897 cites W2098259366 @default.
- W4309848897 cites W2102478648 @default.
- W4309848897 cites W2103823463 @default.
- W4309848897 cites W2117028091 @default.
- W4309848897 cites W2121354606 @default.
- W4309848897 cites W2143340268 @default.
- W4309848897 cites W2143729276 @default.
- W4309848897 cites W2158780936 @default.
- W4309848897 cites W2164481346 @default.
- W4309848897 cites W2165070991 @default.
- W4309848897 cites W2170852633 @default.
- W4309848897 cites W2260555089 @default.
- W4309848897 cites W2270829764 @default.
- W4309848897 cites W2486397717 @default.
- W4309848897 cites W2565726191 @default.
- W4309848897 cites W2592666178 @default.
- W4309848897 cites W2593345096 @default.
- W4309848897 cites W2738491178 @default.
- W4309848897 cites W2765492673 @default.
- W4309848897 cites W2786514708 @default.
- W4309848897 cites W2904802348 @default.
- W4309848897 cites W2914634683 @default.
- W4309848897 cites W2946298500 @default.
- W4309848897 cites W2948696299 @default.
- W4309848897 cites W2991416247 @default.
- W4309848897 cites W3002310885 @default.
- W4309848897 cites W3006476723 @default.
- W4309848897 cites W3010082761 @default.
- W4309848897 cites W3011188387 @default.
- W4309848897 cites W3042689819 @default.
- W4309848897 cites W3044491460 @default.
- W4309848897 cites W3099076257 @default.
- W4309848897 cites W3102011730 @default.
- W4309848897 cites W3120707740 @default.
- W4309848897 cites W3133858702 @default.
- W4309848897 cites W3170103185 @default.
- W4309848897 cites W4210514621 @default.
- W4309848897 cites W4220960180 @default.
- W4309848897 cites W4238567307 @default.
- W4309848897 doi "https://doi.org/10.3390/cells11233750" @default.
- W4309848897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36497011" @default.
- W4309848897 hasPublicationYear "2022" @default.
- W4309848897 type Work @default.
- W4309848897 citedByCount "3" @default.
- W4309848897 countsByYear W43098488972023 @default.
- W4309848897 crossrefType "journal-article" @default.
- W4309848897 hasAuthorship W4309848897A5046706740 @default.
- W4309848897 hasAuthorship W4309848897A5066941082 @default.
- W4309848897 hasAuthorship W4309848897A5071145764 @default.
- W4309848897 hasAuthorship W4309848897A5089790546 @default.
- W4309848897 hasBestOaLocation W43098488971 @default.
- W4309848897 hasConcept C123012128 @default.
- W4309848897 hasConcept C146285616 @default.
- W4309848897 hasConcept C167734588 @default.
- W4309848897 hasConcept C16930146 @default.
- W4309848897 hasConcept C198826908 @default.
- W4309848897 hasConcept C202751555 @default.
- W4309848897 hasConcept C2777025900 @default.
- W4309848897 hasConcept C2780394083 @default.
- W4309848897 hasConcept C502942594 @default.
- W4309848897 hasConcept C55493867 @default.
- W4309848897 hasConcept C62478195 @default.
- W4309848897 hasConcept C75217442 @default.
- W4309848897 hasConcept C86803240 @default.
- W4309848897 hasConcept C95444343 @default.
- W4309848897 hasConceptScore W4309848897C123012128 @default.
- W4309848897 hasConceptScore W4309848897C146285616 @default.
- W4309848897 hasConceptScore W4309848897C167734588 @default.
- W4309848897 hasConceptScore W4309848897C16930146 @default.
- W4309848897 hasConceptScore W4309848897C198826908 @default.
- W4309848897 hasConceptScore W4309848897C202751555 @default.
- W4309848897 hasConceptScore W4309848897C2777025900 @default.