FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309857504> ?p ?o ?g. }

• W4309857504 abstract "ABSTRACT Hematopoiesis is a highly coordinated process that generates all the body's blood cells, and perturbations in embryonic hematopoiesis may result in illnesses ranging from fetal anemia to various leukemias. Correct establishment of hematopoietic progenitor cell fate is essential for the development of adequate blood cell subpopulations, although regulators of cell fate commitment have not been fully defined. Here, we show that primary erythropoiesis and myelopoiesis in zebrafish embryos are synergistically regulated by blf and the drl cluster, as simultaneous depletion led to severe erythrocyte aplasia and excessive macrophage formation at the expense of neutrophil development. Integrative analysis of transcriptome- and genome-wide binding data revealed that blf and drl cluster genes are responsible for constraining the expression of vasculogenesis-promoting genes in the intermediate cell mass and monocytopoiesis-promoting genes in the rostral blood island. This indicates that blf and drl cluster genes act as determinants of the fate commitment of erythroid and myeloid progenitor cells. Furthermore, a rescue screen demonstrated that Zfp932 is a potential mammalian functional equivalent to zebrafish blf and drl cluster genes. Our data provide insight into conserved cell fate commitment mechanisms of primitive hematopoiesis." @default.
• W4309857504 created "2022-11-29" @default.
• W4309857504 creator A5003059265 @default.
• W4309857504 creator A5044654794 @default.
• W4309857504 creator A5054970085 @default.
• W4309857504 creator A5077811982 @default.
• W4309857504 creator A5079974007 @default.
• W4309857504 date "2022-12-14" @default.
• W4309857504 modified "2023-10-17" @default.
• W4309857504 title "<i>blf</i> and the <i>drl</i> cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis" @default.
• W4309857504 cites W1824346003 @default.
• W4309857504 cites W1972589365 @default.
• W4309857504 cites W1976066719 @default.
• W4309857504 cites W1980171480 @default.
• W4309857504 cites W1980758898 @default.
• W4309857504 cites W1980860344 @default.
• W4309857504 cites W1996351707 @default.
• W4309857504 cites W2000672459 @default.
• W4309857504 cites W2032417286 @default.
• W4309857504 cites W2032951893 @default.
• W4309857504 cites W2033380451 @default.
• W4309857504 cites W2038539380 @default.
• W4309857504 cites W2040080187 @default.
• W4309857504 cites W2053188090 @default.
• W4309857504 cites W2062567955 @default.
• W4309857504 cites W2070015044 @default.
• W4309857504 cites W2070451931 @default.
• W4309857504 cites W2072675839 @default.
• W4309857504 cites W2077024843 @default.
• W4309857504 cites W2077654706 @default.
• W4309857504 cites W2079279013 @default.
• W4309857504 cites W2084058545 @default.
• W4309857504 cites W2086226053 @default.
• W4309857504 cites W2095636105 @default.
• W4309857504 cites W2100352070 @default.
• W4309857504 cites W2137840887 @default.
• W4309857504 cites W2142242761 @default.
• W4309857504 cites W2154699417 @default.
• W4309857504 cites W2164445141 @default.
• W4309857504 cites W2165500799 @default.
• W4309857504 cites W2170830174 @default.
• W4309857504 cites W2171808845 @default.
• W4309857504 cites W2176134716 @default.
• W4309857504 cites W2184156621 @default.
• W4309857504 cites W2205695903 @default.
• W4309857504 cites W2301044272 @default.
• W4309857504 cites W2552313455 @default.
• W4309857504 cites W2799497345 @default.
• W4309857504 cites W2945953423 @default.
• W4309857504 cites W2946448434 @default.
• W4309857504 cites W2969591174 @default.
• W4309857504 cites W2995445776 @default.
• W4309857504 cites W2995481296 @default.
• W4309857504 cites W3084082246 @default.
• W4309857504 cites W3112183859 @default.
• W4309857504 cites W3113163651 @default.
• W4309857504 cites W3118934078 @default.
• W4309857504 cites W3194951089 @default.
• W4309857504 cites W4220742697 @default.
• W4309857504 cites W4235722921 @default.
• W4309857504 cites W44648430 @default.
• W4309857504 doi "https://doi.org/10.1242/dev.200919" @default.
• W4309857504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36420817" @default.
• W4309857504 hasPublicationYear "2022" @default.
• W4309857504 type Work @default.
• W4309857504 citedByCount "0" @default.
• W4309857504 crossrefType "journal-article" @default.
• W4309857504 hasAuthorship W4309857504A5003059265 @default.
• W4309857504 hasAuthorship W4309857504A5044654794 @default.
• W4309857504 hasAuthorship W4309857504A5054970085 @default.
• W4309857504 hasAuthorship W4309857504A5077811982 @default.
• W4309857504 hasAuthorship W4309857504A5079974007 @default.
• W4309857504 hasBestOaLocation W43098575041 @default.
• W4309857504 hasConcept C104317684 @default.
• W4309857504 hasConcept C109159458 @default.
• W4309857504 hasConcept C126322002 @default.
• W4309857504 hasConcept C145103041 @default.
• W4309857504 hasConcept C150194340 @default.
• W4309857504 hasConcept C162317418 @default.
• W4309857504 hasConcept C163952510 @default.
• W4309857504 hasConcept C201750760 @default.
• W4309857504 hasConcept C203014093 @default.
• W4309857504 hasConcept C2776878037 @default.
• W4309857504 hasConcept C2778248108 @default.
• W4309857504 hasConcept C2779282312 @default.
• W4309857504 hasConcept C2779703530 @default.
• W4309857504 hasConcept C28328180 @default.
• W4309857504 hasConcept C54355233 @default.
• W4309857504 hasConcept C63101894 @default.
• W4309857504 hasConcept C71924100 @default.
• W4309857504 hasConcept C86339819 @default.
• W4309857504 hasConcept C86803240 @default.
• W4309857504 hasConcept C95444343 @default.
• W4309857504 hasConcept C95862172 @default.
• W4309857504 hasConceptScore W4309857504C104317684 @default.
• W4309857504 hasConceptScore W4309857504C109159458 @default.
• W4309857504 hasConceptScore W4309857504C126322002 @default.
• W4309857504 hasConceptScore W4309857504C145103041 @default.
• W4309857504 hasConceptScore W4309857504C150194340 @default.
• W4309857504 hasConceptScore W4309857504C162317418 @default.

• next