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• W4309862676 abstract "Objectives Using the Asian Working Group for Sarcopenia (AWGS2019) and the European Working Group on Sarcopenia in Older People (EWGSOP2) criteria, this study examined associations of sarcopenia and its components with specific domains of cognitive impairment over time. Design A prospective cohort study with a 2-year follow-up. Setting and Participants This study is part of the Taiwan Initiatives for Geriatric Epidemiological Research (TIGER), which recruited participants aged 65 years old who attended the senior health checkup program at National Taiwan University Hospital (NTUH). Methods Grip strength was measured using a handgrip dynamometer. Walking speed (m/s) was measured as the time required to walk 8 feet. Muscle mass was measured by performing a bioelectrical impedance analysis. Global cognition (assessed using the Taiwanese version of the Montreal Cognitive Assessment) and 4 cognitive domains (memory, executive function, verbal fluency, and attention) were assessed over time. Associations of sarcopenia and its components with cognitive impairment were evaluated after stratification by sex using generalized linear mixed models adjusted for essential covariates for cognitive impairment. Results Compared with robust women, those with severe sarcopenia were more likely to have a global cognitive impairment over time (β = −0.87, P = .03 based on AWGS2019 criteria and β = −1.07, P = .02 based on the EWGSOP2 criteria). Among men, low grip strength was associated with poor scores on measures of global cognition (β = −0.80, P = .03), executive function (β = −0.35, P = .001), verbal fluency (β = −0.31, P = .02), and attention (β = −0.34, P = .008) over time. Conclusions and Implications Severe sarcopenia predicted global and specific domains of cognitive impairment in older adults. Poor grip strength predicted cognitive impairment in men but not in women. A screen for sarcopenia severity and low muscle strength may be used to identify the risk of cognitive impairment." @default.
• W4309862676 created "2022-11-29" @default.
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• W4309862676 date "2023-03-01" @default.
• W4309862676 modified "2023-10-16" @default.
• W4309862676 title "Grip Strength and Sarcopenia Predict 2-Year Cognitive Impairment in Community-Dwelling Older Adults" @default.
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• W4309862676 doi "https://doi.org/10.1016/j.jamda.2022.10.015" @default.
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