FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309875111> ?p ?o ?g. }

• W4309875111 endingPage "114941" @default.
• W4309875111 startingPage "114941" @default.
• W4309875111 abstract "Real-time tracking of neurotransmitter levels in vivo has been technically challenging due to the low spatiotemporal resolution of current methods. Since the imbalance of cortical excitation/inhibition (E:I) ratios are associated with a variety of neurological disorders, accurate monitoring of excitatory and inhibitory neurotransmitter levels is crucial for investigating the underlying neural mechanisms of these conditions. Specifically, levels of the excitatory neurotransmitter L-glutamate, and the inhibitory neurotransmitter GABA, are assumed to play critical roles in the E:I balance. Therefore, in this work, a flexible electrochemical microsensor is developed for real-time simultaneous detection of L-glutamate and GABA. The flexible polyimide substrate was used for easier handling during implantation and measurement, along with less brain damage. Further, by electrochemically depositing Pt-black nanostructures on the sensor’s surface, the active surface area was enhanced for higher sensitivity. This dual neurotransmitter sensor probe was validated under various settings for its performance, including in vitro, ex vivo tests with glutamatergic neuronal cells and in vivo test with anesthetized rats. Additionally, the sensor’s performance has been further investigated in terms of longevity and biocompatibility. Overall, our dual L-glutamate:GABA sensor microprobe has its unique features to enable accurate, real-time, and long-term monitoring of the E:I balance in vivo. Thus, this new tool should aid investigations of neural mechanisms of normal brain function and various neurological disorders." @default.
• W4309875111 created "2022-11-29" @default.
• W4309875111 creator A5007270341 @default.
• W4309875111 creator A5024031906 @default.
• W4309875111 creator A5038366927 @default.
• W4309875111 creator A5052040538 @default.
• W4309875111 creator A5059296116 @default.
• W4309875111 creator A5064332812 @default.
• W4309875111 creator A5075259136 @default.
• W4309875111 creator A5078848270 @default.
• W4309875111 creator A5079570815 @default.
• W4309875111 creator A5083211385 @default.
• W4309875111 creator A5087504327 @default.
• W4309875111 date "2023-02-01" @default.
• W4309875111 modified "2023-10-15" @default.
• W4309875111 title "Development of highly sensitive, flexible dual L-glutamate and GABA microsensors for in vivo brain sensing" @default.
• W4309875111 cites W1987426179 @default.
• W4309875111 cites W1998318340 @default.
• W4309875111 cites W2003760083 @default.
• W4309875111 cites W2007439548 @default.
• W4309875111 cites W2031701023 @default.
• W4309875111 cites W2059750382 @default.
• W4309875111 cites W2084256175 @default.
• W4309875111 cites W2084888955 @default.
• W4309875111 cites W2143205261 @default.
• W4309875111 cites W2148035451 @default.
• W4309875111 cites W2168748231 @default.
• W4309875111 cites W2290324728 @default.
• W4309875111 cites W2334244908 @default.
• W4309875111 cites W2507186467 @default.
• W4309875111 cites W2776647645 @default.
• W4309875111 cites W2791997660 @default.
• W4309875111 cites W2867620004 @default.
• W4309875111 cites W2911738484 @default.
• W4309875111 cites W2912239947 @default.
• W4309875111 cites W2913387416 @default.
• W4309875111 cites W2946386151 @default.
• W4309875111 cites W2979371633 @default.
• W4309875111 cites W2981478653 @default.
• W4309875111 cites W3044372583 @default.
• W4309875111 cites W3097951976 @default.
• W4309875111 cites W3137941636 @default.
• W4309875111 cites W3181176402 @default.
• W4309875111 cites W3216151710 @default.
• W4309875111 cites W4280502651 @default.
• W4309875111 doi "https://doi.org/10.1016/j.bios.2022.114941" @default.
• W4309875111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36455372" @default.
• W4309875111 hasPublicationYear "2023" @default.
• W4309875111 type Work @default.
• W4309875111 citedByCount "3" @default.
• W4309875111 countsByYear W43098751112023 @default.
• W4309875111 crossrefType "journal-article" @default.
• W4309875111 hasAuthorship W4309875111A5007270341 @default.
• W4309875111 hasAuthorship W4309875111A5024031906 @default.
• W4309875111 hasAuthorship W4309875111A5038366927 @default.
• W4309875111 hasAuthorship W4309875111A5052040538 @default.
• W4309875111 hasAuthorship W4309875111A5059296116 @default.
• W4309875111 hasAuthorship W4309875111A5064332812 @default.
• W4309875111 hasAuthorship W4309875111A5075259136 @default.
• W4309875111 hasAuthorship W4309875111A5078848270 @default.
• W4309875111 hasAuthorship W4309875111A5079570815 @default.
• W4309875111 hasAuthorship W4309875111A5083211385 @default.
• W4309875111 hasAuthorship W4309875111A5087504327 @default.
• W4309875111 hasConcept C112592302 @default.
• W4309875111 hasConcept C12554922 @default.
• W4309875111 hasConcept C150903083 @default.
• W4309875111 hasConcept C169760540 @default.
• W4309875111 hasConcept C170493617 @default.
• W4309875111 hasConcept C17077164 @default.
• W4309875111 hasConcept C185592680 @default.
• W4309875111 hasConcept C207001950 @default.
• W4309875111 hasConcept C26291073 @default.
• W4309875111 hasConcept C2776219046 @default.
• W4309875111 hasConcept C2780648746 @default.
• W4309875111 hasConcept C50156730 @default.
• W4309875111 hasConcept C529278444 @default.
• W4309875111 hasConcept C55493867 @default.
• W4309875111 hasConcept C61174792 @default.
• W4309875111 hasConcept C86803240 @default.
• W4309875111 hasConceptScore W4309875111C112592302 @default.
• W4309875111 hasConceptScore W4309875111C12554922 @default.
• W4309875111 hasConceptScore W4309875111C150903083 @default.
• W4309875111 hasConceptScore W4309875111C169760540 @default.
• W4309875111 hasConceptScore W4309875111C170493617 @default.
• W4309875111 hasConceptScore W4309875111C17077164 @default.
• W4309875111 hasConceptScore W4309875111C185592680 @default.
• W4309875111 hasConceptScore W4309875111C207001950 @default.
• W4309875111 hasConceptScore W4309875111C26291073 @default.
• W4309875111 hasConceptScore W4309875111C2776219046 @default.
• W4309875111 hasConceptScore W4309875111C2780648746 @default.
• W4309875111 hasConceptScore W4309875111C50156730 @default.
• W4309875111 hasConceptScore W4309875111C529278444 @default.
• W4309875111 hasConceptScore W4309875111C55493867 @default.
• W4309875111 hasConceptScore W4309875111C61174792 @default.
• W4309875111 hasConceptScore W4309875111C86803240 @default.
• W4309875111 hasFunder F4320306076 @default.
• W4309875111 hasLocation W43098751111 @default.
• W4309875111 hasLocation W43098751112 @default.

• next