FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309878951> ?p ?o ?g. }

• W4309878951 endingPage "1897" @default.
• W4309878951 startingPage "1827" @default.
• W4309878951 abstract "The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a function of cardiac output and pulmonary vascular resistance, and pulmonary vascular resistance is inversely proportional to the fourth power of the intraluminal radius of the pulmonary artery. Therefore, a very small decrease of the pulmonary vascular lumen diameter results in a significant increase in pulmonary vascular resistance and pulmonary arterial pressure. Pulmonary arterial hypertension is a fatal and progressive disease with poor prognosis. Regardless of the initial pathogenic triggers, sustained pulmonary vasoconstriction, concentric vascular remodeling, occlusive intimal lesions, in situ thrombosis, and vascular wall stiffening are the major and direct causes for elevated pulmonary vascular resistance in patients with pulmonary arterial hypertension and other forms of precapillary pulmonary hypertension. In this review, we aim to discuss the basic principles and physiological mechanisms involved in the regulation of lung vascular hemodynamics and pulmonary vascular function, the changes in the pulmonary vasculature that contribute to the increased vascular resistance and arterial pressure, and the pathogenic mechanisms involved in the development and progression of pulmonary hypertension. We focus on reviewing the pathogenic roles of membrane receptors, ion channels, and intracellular Ca2+ signaling in pulmonary vascular smooth muscle cells in the development and progression of pulmonary hypertension." @default.
• W4309878951 created "2022-11-29" @default.
• W4309878951 creator A5008213446 @default.
• W4309878951 creator A5053815668 @default.
• W4309878951 creator A5056829553 @default.
• W4309878951 date "2023-07-01" @default.
• W4309878951 modified "2023-10-09" @default.
• W4309878951 title "Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca²⁺ signaling" @default.
• W4309878951 cites W102023072 @default.
• W4309878951 cites W115896630 @default.
• W4309878951 cites W13250750 @default.
• W4309878951 cites W134363133 @default.
• W4309878951 cites W135106167 @default.
• W4309878951 cites W1485297825 @default.
• W4309878951 cites W1487910746 @default.
• W4309878951 cites W149940350 @default.
• W4309878951 cites W1499833703 @default.
• W4309878951 cites W1502095639 @default.
• W4309878951 cites W1504123405 @default.
• W4309878951 cites W1514517749 @default.
• W4309878951 cites W1517907148 @default.
• W4309878951 cites W1523706411 @default.
• W4309878951 cites W1530738367 @default.
• W4309878951 cites W1547203551 @default.
• W4309878951 cites W1549316628 @default.
• W4309878951 cites W1561041814 @default.
• W4309878951 cites W1599277155 @default.
• W4309878951 cites W1606441445 @default.
• W4309878951 cites W161963765 @default.
• W4309878951 cites W1643375850 @default.
• W4309878951 cites W1753089048 @default.
• W4309878951 cites W1755496226 @default.
• W4309878951 cites W1771949227 @default.
• W4309878951 cites W177395109 @default.
• W4309878951 cites W1820050296 @default.
• W4309878951 cites W1825951622 @default.
• W4309878951 cites W1866413456 @default.
• W4309878951 cites W1876419424 @default.
• W4309878951 cites W1883147193 @default.
• W4309878951 cites W1888188715 @default.
• W4309878951 cites W1889047426 @default.
• W4309878951 cites W1893878897 @default.
• W4309878951 cites W1901856024 @default.
• W4309878951 cites W1906233140 @default.
• W4309878951 cites W1926185647 @default.
• W4309878951 cites W1952340673 @default.
• W4309878951 cites W1956254370 @default.
• W4309878951 cites W1964124586 @default.
• W4309878951 cites W1964890294 @default.
• W4309878951 cites W1965907479 @default.
• W4309878951 cites W1966099089 @default.
• W4309878951 cites W1966416602 @default.
• W4309878951 cites W1966954307 @default.
• W4309878951 cites W1967478282 @default.
• W4309878951 cites W1968143686 @default.
• W4309878951 cites W1968659112 @default.
• W4309878951 cites W1968894140 @default.
• W4309878951 cites W1971352742 @default.
• W4309878951 cites W1972235612 @default.
• W4309878951 cites W1975443612 @default.
• W4309878951 cites W1975566020 @default.
• W4309878951 cites W1975924570 @default.
• W4309878951 cites W1975982686 @default.
• W4309878951 cites W1976117941 @default.
• W4309878951 cites W1977856772 @default.
• W4309878951 cites W1977962361 @default.
• W4309878951 cites W1978734517 @default.
• W4309878951 cites W1979969712 @default.
• W4309878951 cites W1980619986 @default.
• W4309878951 cites W1980975971 @default.
• W4309878951 cites W1983001428 @default.
• W4309878951 cites W1984887498 @default.
• W4309878951 cites W1985417036 @default.
• W4309878951 cites W1985532214 @default.
• W4309878951 cites W1986604107 @default.
• W4309878951 cites W1987251432 @default.
• W4309878951 cites W1988949024 @default.
• W4309878951 cites W1989174616 @default.
• W4309878951 cites W1989955397 @default.
• W4309878951 cites W1990344393 @default.
• W4309878951 cites W1990681728 @default.
• W4309878951 cites W1991870376 @default.
• W4309878951 cites W1992427628 @default.
• W4309878951 cites W1992718978 @default.
• W4309878951 cites W1993938009 @default.
• W4309878951 cites W1994283109 @default.
• W4309878951 cites W1994378425 @default.
• W4309878951 cites W1994536035 @default.
• W4309878951 cites W1995110919 @default.
• W4309878951 cites W1995214889 @default.
• W4309878951 cites W1995338702 @default.
• W4309878951 cites W1999087432 @default.
• W4309878951 cites W1999388852 @default.
• W4309878951 cites W1999887461 @default.
• W4309878951 cites W2001907298 @default.
• W4309878951 cites W2001917660 @default.
• W4309878951 cites W2002574027 @default.
• W4309878951 cites W2002594335 @default.

• next