FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309880015> ?p ?o ?g. }

• W4309880015 endingPage "1154" @default.
• W4309880015 startingPage "1144" @default.
• W4309880015 abstract "The primary objective of this prospective pilot trial was to assess the safety and feasibility of lung functional avoidance radiation therapy (RT) with 4-dimensional (4D) computed tomography (CT) ventilation imaging.Patients with primary lung cancer or metastatic disease to the lungs to receive conventionally fractionated RT (CFRT) or stereotactic body RT (SBRT) were eligible. Standard-of-care 4D-CT scans were used to generate ventilation images through image processing/analysis. Each patient required a standard intensity modulated RT plan and ventilation image guided functional avoidance plan. The primary endpoint was the safety of functional avoidance RT, defined as the rate of grade ≥3 adverse events (AEs) that occurred ≤12 months after treatment. Protocol treatment was considered safe if the rates of grade ≥3 pneumonitis and esophagitis were <13% and <21%, respectively for CFRT, and if the rate of any grade ≥3 AEs was <28% for SBRT. Feasibility of functional avoidance RT was assessed by comparison of dose metrics between the 2 plans using the Wilcoxon signed-rank test.Between May 2015 and November 2019, 34 patients with non-small cell lung cancer were enrolled, and 33 patients were evaluable (n = 24 for CFRT; n = 9 for SBRT). Median follow-up was 14.7 months. For CFRT, the rates of grade ≥3 pneumonitis and esophagitis were 4.2% (95% confidence interval, 0.1%-21.1%) and 12.5% (2.7%-32.4%). For SBRT, no patients developed grade ≥3 AEs. Compared with the standard plans, the functional avoidance plans significantly (P < .01) reduced the lung dose-function metrics without compromising target coverage or adherence to standard organs at risk constraints.This study, representing one of the first prospective investigations on lung functional avoidance RT, demonstrated that the 4D-CT ventilation image guided functional avoidance RT that significantly reduced dose to ventilated lung regions could be safely administered, adding to the growing body of evidence for its clinical utility." @default.
• W4309880015 created "2022-11-29" @default.
• W4309880015 creator A5012356605 @default.
• W4309880015 creator A5022057001 @default.
• W4309880015 creator A5022367698 @default.
• W4309880015 creator A5040244448 @default.
• W4309880015 creator A5046591945 @default.
• W4309880015 creator A5049973737 @default.
• W4309880015 creator A5057311517 @default.
• W4309880015 creator A5072265173 @default.
• W4309880015 creator A5083781774 @default.
• W4309880015 creator A5089000532 @default.
• W4309880015 creator A5090328595 @default.
• W4309880015 date "2023-04-01" @default.
• W4309880015 modified "2023-10-15" @default.
• W4309880015 title "Four-Dimensional Computed Tomography Ventilation Image-Guided Lung Functional Avoidance Radiation Therapy: A Single-Arm Prospective Pilot Clinical Trial" @default.
• W4309880015 cites W1173911961 @default.
• W4309880015 cites W1968899146 @default.
• W4309880015 cites W1973980747 @default.
• W4309880015 cites W1974477570 @default.
• W4309880015 cites W1990835448 @default.
• W4309880015 cites W2006244857 @default.
• W4309880015 cites W2014865645 @default.
• W4309880015 cites W2017164285 @default.
• W4309880015 cites W2020180938 @default.
• W4309880015 cites W2025286777 @default.
• W4309880015 cites W2025862469 @default.
• W4309880015 cites W2030653110 @default.
• W4309880015 cites W2035619816 @default.
• W4309880015 cites W2037019440 @default.
• W4309880015 cites W2037171241 @default.
• W4309880015 cites W2046260479 @default.
• W4309880015 cites W2067940417 @default.
• W4309880015 cites W2092718150 @default.
• W4309880015 cites W2096786305 @default.
• W4309880015 cites W2115646671 @default.
• W4309880015 cites W2126393454 @default.
• W4309880015 cites W2136845661 @default.
• W4309880015 cites W2139347600 @default.
• W4309880015 cites W2144375241 @default.
• W4309880015 cites W2144475774 @default.
• W4309880015 cites W2151300028 @default.
• W4309880015 cites W2160068722 @default.
• W4309880015 cites W2161523978 @default.
• W4309880015 cites W2178570731 @default.
• W4309880015 cites W2192799736 @default.
• W4309880015 cites W2193846987 @default.
• W4309880015 cites W2261139904 @default.
• W4309880015 cites W2284871039 @default.
• W4309880015 cites W2289601583 @default.
• W4309880015 cites W2303102115 @default.
• W4309880015 cites W2604900694 @default.
• W4309880015 cites W2608546805 @default.
• W4309880015 cites W2609459785 @default.
• W4309880015 cites W2753065806 @default.
• W4309880015 cites W2801321057 @default.
• W4309880015 cites W2885201947 @default.
• W4309880015 cites W2902306407 @default.
• W4309880015 cites W2906437789 @default.
• W4309880015 cites W2945958246 @default.
• W4309880015 cites W3001734243 @default.
• W4309880015 cites W3209930766 @default.
• W4309880015 cites W4229372791 @default.
• W4309880015 cites W4245666729 @default.
• W4309880015 doi "https://doi.org/10.1016/j.ijrobp.2022.11.026" @default.
• W4309880015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36427643" @default.
• W4309880015 hasPublicationYear "2023" @default.
• W4309880015 type Work @default.
• W4309880015 citedByCount "1" @default.
• W4309880015 countsByYear W43098800152023 @default.
• W4309880015 crossrefType "journal-article" @default.
• W4309880015 hasAuthorship W4309880015A5012356605 @default.
• W4309880015 hasAuthorship W4309880015A5022057001 @default.
• W4309880015 hasAuthorship W4309880015A5022367698 @default.
• W4309880015 hasAuthorship W4309880015A5040244448 @default.
• W4309880015 hasAuthorship W4309880015A5046591945 @default.
• W4309880015 hasAuthorship W4309880015A5049973737 @default.
• W4309880015 hasAuthorship W4309880015A5057311517 @default.
• W4309880015 hasAuthorship W4309880015A5072265173 @default.
• W4309880015 hasAuthorship W4309880015A5083781774 @default.
• W4309880015 hasAuthorship W4309880015A5089000532 @default.
• W4309880015 hasAuthorship W4309880015A5090328595 @default.
• W4309880015 hasConcept C126322002 @default.
• W4309880015 hasConcept C126838900 @default.
• W4309880015 hasConcept C168563851 @default.
• W4309880015 hasConcept C197934379 @default.
• W4309880015 hasConcept C203092338 @default.
• W4309880015 hasConcept C2776256026 @default.
• W4309880015 hasConcept C2777714996 @default.
• W4309880015 hasConcept C2779134260 @default.
• W4309880015 hasConcept C2779524853 @default.
• W4309880015 hasConcept C2779920096 @default.
• W4309880015 hasConcept C2989005 @default.
• W4309880015 hasConcept C43270747 @default.
• W4309880015 hasConcept C44249647 @default.
• W4309880015 hasConcept C509974204 @default.
• W4309880015 hasConcept C71924100 @default.
• W4309880015 hasConcept C9267231 @default.

• next