FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309880386> ?p ?o ?g. }

• W4309880386 endingPage "117" @default.
• W4309880386 startingPage "98" @default.
• W4309880386 abstract "Growing evidence suggests the involvement of the microbiota-gut-brain axis in cognitive impairment induced by sleep deprivation (SD), however how the microbiota-gut-brain axis work remains elusive. Here, we discovered that chronic SD induced intestinal dysbiosis, activated NLRP3 inflammasome in the colon and brain, destructed intestinal/blood-brain barrier, and impaired cognitive function in mice. Transplantation of SD microbiota could almost mimic the pathological and behavioral changes caused by chronic SD. Furthermore, all the behavioral and pathological abnormalities were practically reversed in chronic sleep-deprived NLRP3-/- mice. Regional knockdown NLRP3 expression in the gut and hippocampus, respectively. We observed that down-regulation of NLRP3 in the hippocampus inhibited neuroinflammation, and ameliorated synaptic dysfunction and cognitive impairment induced by chronic SD. More intriguingly, the down-regulation of NLRP3 in the gut protected the intestinal barrier, attenuated the levels of peripheral inflammatory factors, down-regulated the expression of NLRP3 in the brain, and improved cognitive function in chronic SD mice. Our results identified gut microbiota as a driver in chronic SD and highlighted the NLRP3 inflammasome as a key regulator within the microbiota-gut-brain axis." @default.
• W4309880386 created "2022-11-29" @default.
• W4309880386 creator A5018624401 @default.
• W4309880386 creator A5020376217 @default.
• W4309880386 creator A5021495254 @default.
• W4309880386 creator A5040897632 @default.
• W4309880386 creator A5044901407 @default.
• W4309880386 creator A5052376578 @default.
• W4309880386 creator A5075524122 @default.
• W4309880386 creator A5079203532 @default.
• W4309880386 creator A5085546073 @default.
• W4309880386 date "2023-02-01" @default.
• W4309880386 modified "2023-10-16" @default.
• W4309880386 title "Intestinal dysbiosis mediates cognitive impairment via the intestine and brain NLRP3 inflammasome activation in chronic sleep deprivation" @default.
• W4309880386 cites W1726094883 @default.
• W4309880386 cites W2013333500 @default.
• W4309880386 cites W2071174103 @default.
• W4309880386 cites W2082307168 @default.
• W4309880386 cites W2086155425 @default.
• W4309880386 cites W2087243986 @default.
• W4309880386 cites W2089503694 @default.
• W4309880386 cites W2096058937 @default.
• W4309880386 cites W2129917444 @default.
• W4309880386 cites W2148230248 @default.
• W4309880386 cites W2340717842 @default.
• W4309880386 cites W2508213551 @default.
• W4309880386 cites W2531542945 @default.
• W4309880386 cites W2539003831 @default.
• W4309880386 cites W2564506494 @default.
• W4309880386 cites W2567271475 @default.
• W4309880386 cites W2606051721 @default.
• W4309880386 cites W2609979439 @default.
• W4309880386 cites W2615609848 @default.
• W4309880386 cites W2616414475 @default.
• W4309880386 cites W2728294044 @default.
• W4309880386 cites W2762048636 @default.
• W4309880386 cites W2774851697 @default.
• W4309880386 cites W2783934455 @default.
• W4309880386 cites W2799884346 @default.
• W4309880386 cites W2883874525 @default.
• W4309880386 cites W2899574052 @default.
• W4309880386 cites W2912003143 @default.
• W4309880386 cites W2912651324 @default.
• W4309880386 cites W2921998529 @default.
• W4309880386 cites W2944481004 @default.
• W4309880386 cites W2951544248 @default.
• W4309880386 cites W2954782052 @default.
• W4309880386 cites W2969172532 @default.
• W4309880386 cites W2969822493 @default.
• W4309880386 cites W2970148487 @default.
• W4309880386 cites W2970686316 @default.
• W4309880386 cites W2972007077 @default.
• W4309880386 cites W2972396284 @default.
• W4309880386 cites W2980599943 @default.
• W4309880386 cites W2982301513 @default.
• W4309880386 cites W2987356303 @default.
• W4309880386 cites W3005342570 @default.
• W4309880386 cites W3005836481 @default.
• W4309880386 cites W3006857944 @default.
• W4309880386 cites W3008599743 @default.
• W4309880386 cites W3028489996 @default.
• W4309880386 cites W3087789132 @default.
• W4309880386 cites W3094330590 @default.
• W4309880386 cites W3111897458 @default.
• W4309880386 cites W3126277686 @default.
• W4309880386 cites W3127070382 @default.
• W4309880386 cites W3158878919 @default.
• W4309880386 cites W3159336275 @default.
• W4309880386 cites W3176205589 @default.
• W4309880386 cites W646218571 @default.
• W4309880386 doi "https://doi.org/10.1016/j.bbi.2022.11.013" @default.
• W4309880386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36427810" @default.
• W4309880386 hasPublicationYear "2023" @default.
• W4309880386 type Work @default.
• W4309880386 citedByCount "4" @default.
• W4309880386 countsByYear W43098803862023 @default.
• W4309880386 crossrefType "journal-article" @default.
• W4309880386 hasAuthorship W4309880386A5018624401 @default.
• W4309880386 hasAuthorship W4309880386A5020376217 @default.
• W4309880386 hasAuthorship W4309880386A5021495254 @default.
• W4309880386 hasAuthorship W4309880386A5040897632 @default.
• W4309880386 hasAuthorship W4309880386A5044901407 @default.
• W4309880386 hasAuthorship W4309880386A5052376578 @default.
• W4309880386 hasAuthorship W4309880386A5075524122 @default.
• W4309880386 hasAuthorship W4309880386A5079203532 @default.
• W4309880386 hasAuthorship W4309880386A5085546073 @default.
• W4309880386 hasConcept C126322002 @default.
• W4309880386 hasConcept C15744967 @default.
• W4309880386 hasConcept C169760540 @default.
• W4309880386 hasConcept C177857423 @default.
• W4309880386 hasConcept C203014093 @default.
• W4309880386 hasConcept C2776914184 @default.
• W4309880386 hasConcept C2777165150 @default.
• W4309880386 hasConcept C2777209026 @default.
• W4309880386 hasConcept C2781161787 @default.
• W4309880386 hasConcept C539455810 @default.
• W4309880386 hasConcept C71924100 @default.
• W4309880386 hasConcept C87753298 @default.

• next