FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309885291> ?p ?o ?g. }

• W4309885291 abstract "Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic paramyxovirus which belongs to Henipavirus family, causes severe respiratory disease, and may lead to fatal encephalitis infections in humans. NiV and HeV glycoproteins (G) bind to the highly conserved human ephrin-B2 and B3 (EFNB2 & EFNB3) cell surface proteins to mediate the viral entry. In this study, various molecular modelling approaches were employed to understand protein-protein interaction (PPI) of NiV and HeV glycoprotein (84% sequence similarity) with Human EFN (B2 and B3) to investigate the molecular mechanism of interaction at atomic level. Our computational study emphasized the PPI profile of both the viral glycoproteins with EFN (B2 and B3) in terms of non-bonded contacts, H-bonds, salt bridges, and identification of interface hotspot residues which play a critical role in the formation of complexes that mediate viral fusion and entry into the host cell. According to the reports, EFNB2 is considered to be more actively involved in the attachment with the NiV and HeV glycoprotein; interestingly the current computational study has displayed more conformational stability in HeV/NiV glycoprotein with EFNB2 complex with relatively high binding energy as compared to EFNB3. During the MD simulation, the number of H-bond formations was observed to be less in the case of EFNB3 complexes, which may be the possible reason for less conformational stability in the EFNB3 complexes. The current detailed interaction study on the PPI may put a path forward in designing peptide inhibitors to obstruct the interaction of viral glycoproteins with host proteins, thereby inhibiting viral entry. The viral attachment and fusion of Nipah and Hendra virus was explored through the interaction between viral glycoprotein and the host cell surface ephrin protein. The MD simulation results displayed more stability in Nipah and Hendra glycoprotein with EFNB2 as compared to EFNB3. The residue Glu533 in the central cavity of HeV/NiV glycoprotein protein identified as the potential hotspot in binding with the G-H loop of EFNB2." @default.
• W4309885291 created "2022-11-29" @default.
• W4309885291 creator A5016860709 @default.
• W4309885291 creator A5036199961 @default.
• W4309885291 creator A5042534009 @default.
• W4309885291 date "2022-11-23" @default.
• W4309885291 modified "2023-10-17" @default.
• W4309885291 title "Glycoprotein attachment with host cell surface receptor ephrin B2 and B3 in mediating entry of nipah and hendra virus: a computational investigation" @default.
• W4309885291 cites W1031578623 @default.
• W4309885291 cites W1963708153 @default.
• W4309885291 cites W1978614903 @default.
• W4309885291 cites W1992045316 @default.
• W4309885291 cites W1999267207 @default.
• W4309885291 cites W1999390565 @default.
• W4309885291 cites W1999800992 @default.
• W4309885291 cites W2001366186 @default.
• W4309885291 cites W2010791652 @default.
• W4309885291 cites W2011937142 @default.
• W4309885291 cites W2032294909 @default.
• W4309885291 cites W2033674509 @default.
• W4309885291 cites W2041805602 @default.
• W4309885291 cites W2044172327 @default.
• W4309885291 cites W2060872117 @default.
• W4309885291 cites W2063516500 @default.
• W4309885291 cites W2070506154 @default.
• W4309885291 cites W2086003265 @default.
• W4309885291 cites W2097874743 @default.
• W4309885291 cites W2107379480 @default.
• W4309885291 cites W2109513041 @default.
• W4309885291 cites W2110120447 @default.
• W4309885291 cites W2115167726 @default.
• W4309885291 cites W2122500867 @default.
• W4309885291 cites W2127495252 @default.
• W4309885291 cites W2128572087 @default.
• W4309885291 cites W2130479394 @default.
• W4309885291 cites W2132589721 @default.
• W4309885291 cites W2132629607 @default.
• W4309885291 cites W2133406801 @default.
• W4309885291 cites W2136206140 @default.
• W4309885291 cites W2149145483 @default.
• W4309885291 cites W2150537020 @default.
• W4309885291 cites W2154019529 @default.
• W4309885291 cites W2159376668 @default.
• W4309885291 cites W2164027317 @default.
• W4309885291 cites W2288504620 @default.
• W4309885291 cites W2341124026 @default.
• W4309885291 cites W2417315358 @default.
• W4309885291 cites W2537853126 @default.
• W4309885291 cites W2611314002 @default.
• W4309885291 cites W261845092 @default.
• W4309885291 cites W2754901417 @default.
• W4309885291 cites W2804822363 @default.
• W4309885291 cites W2907926287 @default.
• W4309885291 cites W2937961491 @default.
• W4309885291 cites W2952767236 @default.
• W4309885291 cites W2993967009 @default.
• W4309885291 cites W3006928215 @default.
• W4309885291 cites W3020735101 @default.
• W4309885291 cites W3087127729 @default.
• W4309885291 cites W3151852005 @default.
• W4309885291 cites W4206065577 @default.
• W4309885291 cites W4210918486 @default.
• W4309885291 cites W4224292397 @default.
• W4309885291 cites W4292136624 @default.
• W4309885291 doi "https://doi.org/10.1007/s12039-022-02110-9" @default.
• W4309885291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36465097" @default.
• W4309885291 hasPublicationYear "2022" @default.
• W4309885291 type Work @default.
• W4309885291 citedByCount "5" @default.
• W4309885291 countsByYear W43098852912023 @default.
• W4309885291 crossrefType "journal-article" @default.
• W4309885291 hasAuthorship W4309885291A5016860709 @default.
• W4309885291 hasAuthorship W4309885291A5036199961 @default.
• W4309885291 hasAuthorship W4309885291A5042534009 @default.
• W4309885291 hasBestOaLocation W43098852911 @default.
• W4309885291 hasConcept C108625454 @default.
• W4309885291 hasConcept C11804247 @default.
• W4309885291 hasConcept C140704245 @default.
• W4309885291 hasConcept C159047783 @default.
• W4309885291 hasConcept C159110408 @default.
• W4309885291 hasConcept C185592680 @default.
• W4309885291 hasConcept C2522874641 @default.
• W4309885291 hasConcept C2776997796 @default.
• W4309885291 hasConcept C2777469322 @default.
• W4309885291 hasConcept C2909811801 @default.
• W4309885291 hasConcept C41685203 @default.
• W4309885291 hasConcept C55493867 @default.
• W4309885291 hasConcept C58475186 @default.
• W4309885291 hasConcept C71924100 @default.
• W4309885291 hasConcept C86803240 @default.
• W4309885291 hasConcept C95444343 @default.
• W4309885291 hasConceptScore W4309885291C108625454 @default.
• W4309885291 hasConceptScore W4309885291C11804247 @default.
• W4309885291 hasConceptScore W4309885291C140704245 @default.
• W4309885291 hasConceptScore W4309885291C159047783 @default.
• W4309885291 hasConceptScore W4309885291C159110408 @default.
• W4309885291 hasConceptScore W4309885291C185592680 @default.
• W4309885291 hasConceptScore W4309885291C2522874641 @default.
• W4309885291 hasConceptScore W4309885291C2776997796 @default.
• W4309885291 hasConceptScore W4309885291C2777469322 @default.

• next