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- W4309915784 abstract "A library of quinoline-based hydrazones bearing 1H-1,2,3-triazole core was designed, synthesized, and evaluated for their antiplasmodial activity against the drug-resistant Plasmodium falciparum W2 strain. The inclusion of pyrazine-2-carboxylic acid with a flexible propyl spacer afforded the most active scaffold with an IC50 value of 0.26 μM. Mechanistically, the compound inhibited heme to hemozoin formation, as demonstrated by UV-vis and mass spectral studies." @default.
- W4309915784 created "2022-11-30" @default.
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- W4309915784 date "2022-12-01" @default.
- W4309915784 modified "2023-10-16" @default.
- W4309915784 title "Quinoline‐based heterocyclic hydrazones: Design, synthesis, anti‐plasmodial assessment, and mechanistic insights" @default.
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- W4309915784 doi "https://doi.org/10.1111/cbdd.14185" @default.
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