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- W4309922710 abstract "To evaluate cone photoreceptor density in clinically unremarkable retinal regions in patients with age-related macular degeneration (AMD) using adaptive optics scanning laser ophthalmoscopy (AOSLO).Prospective case series with normal comparison group.Ten eyes of 7 patients with intermediate AMD were studied, including 4 with predominantly subretinal drusenoid deposits (SDD) and 3 without SDD. Macular regions with a clinical absence of AMD-associated lesions were identified by cone packing structure on AOSLO and optical coherence tomography. Cone density was measured in 1174 clinically unremarkable regions within the central subfield (CSF), the inner (IR), and outer rings (OR) of the Early Treatment Diabetic Retinopathy Study grid over 39.6 ± 3.3 months and compared with age-matched normal values obtained in 17 participants.Cone density decreased at 98.3% of the examined locations over time in the eyes with AMD. In the CSF, IR, and OR, cones declined by -255 ± 135, -133 ± 45, and -59 ± 24 cones/degree2/year, respectively, in eyes with SDD, and by -212 ± 89, -83 ± 37, and -27 ± 18 cones/degree2/year, respectively, in eyes without SDD. The percentage of retinal loci with cone density lower than normal (Z score < -2) increased over the follow-up: from 42% at the baseline to 80% at the last visit in eyes with SDD and from 31% to 70% in eyes without SDD.AOSLO revealed cone photoreceptor loss in regions that appear otherwise unremarkable clinically. These findings may help explain the loss of mesopic sensitivity reported in these areas in eyes with intermediate AMD." @default.
- W4309922710 created "2022-11-30" @default.
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- W4309922710 date "2023-04-01" @default.
- W4309922710 modified "2023-10-13" @default.
- W4309922710 title "In Vivo Longitudinal Measurement of Cone Photoreceptor Density in Intermediate Age-Related Macular Degeneration" @default.
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- W4309922710 cites W172046951 @default.
- W4309922710 cites W1853674701 @default.
- W4309922710 cites W1857170741 @default.
- W4309922710 cites W1964602001 @default.
- W4309922710 cites W1970140546 @default.
- W4309922710 cites W1973908083 @default.
- W4309922710 cites W1987146434 @default.
- W4309922710 cites W1993828795 @default.
- W4309922710 cites W1993969132 @default.
- W4309922710 cites W1996079559 @default.
- W4309922710 cites W2001855698 @default.
- W4309922710 cites W2005859915 @default.
- W4309922710 cites W2006632914 @default.
- W4309922710 cites W2007032134 @default.
- W4309922710 cites W2011710954 @default.
- W4309922710 cites W2011845506 @default.
- W4309922710 cites W2015098402 @default.
- W4309922710 cites W2025979869 @default.
- W4309922710 cites W2040542760 @default.
- W4309922710 cites W2045011938 @default.
- W4309922710 cites W2054899217 @default.
- W4309922710 cites W2059528382 @default.
- W4309922710 cites W2060336605 @default.
- W4309922710 cites W2062160894 @default.
- W4309922710 cites W2069131127 @default.
- W4309922710 cites W2071759179 @default.
- W4309922710 cites W2072774299 @default.
- W4309922710 cites W2075935723 @default.
- W4309922710 cites W2076270591 @default.
- W4309922710 cites W2078466179 @default.
- W4309922710 cites W2085244007 @default.
- W4309922710 cites W2087344433 @default.
- W4309922710 cites W2107546491 @default.
- W4309922710 cites W2141403362 @default.
- W4309922710 cites W2171855270 @default.
- W4309922710 cites W2220565289 @default.
- W4309922710 cites W2291663409 @default.
- W4309922710 cites W2298879452 @default.
- W4309922710 cites W2346856078 @default.
- W4309922710 cites W2398387635 @default.
- W4309922710 cites W2543173007 @default.
- W4309922710 cites W2561086534 @default.
- W4309922710 cites W2561401256 @default.
- W4309922710 cites W2568229308 @default.
- W4309922710 cites W2586361874 @default.
- W4309922710 cites W2592042721 @default.
- W4309922710 cites W2619171481 @default.
- W4309922710 cites W2741397724 @default.
- W4309922710 cites W2790801415 @default.
- W4309922710 cites W2802530436 @default.
- W4309922710 cites W2807327270 @default.
- W4309922710 cites W2811847007 @default.
- W4309922710 cites W2884312469 @default.
- W4309922710 cites W2885918621 @default.
- W4309922710 cites W2886969976 @default.
- W4309922710 cites W2888854438 @default.
- W4309922710 cites W2889394299 @default.
- W4309922710 cites W2898549572 @default.
- W4309922710 cites W2919371914 @default.
- W4309922710 cites W2938857728 @default.
- W4309922710 cites W2979815385 @default.
- W4309922710 cites W2984320094 @default.
- W4309922710 cites W3003595546 @default.
- W4309922710 cites W3032655302 @default.
- W4309922710 cites W3036135188 @default.
- W4309922710 cites W3043999722 @default.
- W4309922710 cites W3045718879 @default.
- W4309922710 cites W3048711315 @default.
- W4309922710 cites W3103744139 @default.
- W4309922710 cites W3122999042 @default.
- W4309922710 cites W3205933965 @default.
- W4309922710 cites W4211199473 @default.
- W4309922710 cites W4214489004 @default.
- W4309922710 cites W4234180827 @default.
- W4309922710 cites W4252865652 @default.
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- W4309922710 cites W4300191192 @default.
- W4309922710 cites W91872680 @default.
- W4309922710 doi "https://doi.org/10.1016/j.ajo.2022.11.020" @default.
- W4309922710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36436549" @default.
- W4309922710 hasPublicationYear "2023" @default.
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