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- W4309994499 abstract "Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of ARL17A/B, encoding ADP ribosylation factor like GTPase 17A/B, in induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. ARL17A/B was also differentially expressed in primary motor neurons isolated from patients with ALS. ARL17A/B transcript was present at significantly lower levels in ALS iPSC-derived motor neurons. These analyses will begin to define the transcriptional landscape of ALS." @default.
- W4309994499 created "2022-11-30" @default.
- W4309994499 creator A5024900493 @default.
- W4309994499 date "2022-11-24" @default.
- W4309994499 modified "2023-10-14" @default.
- W4309994499 title "Differential expression of ARL17A/B in amyotrophic lateral sclerosis." @default.
- W4309994499 doi "https://doi.org/10.31219/osf.io/vb8nj" @default.
- W4309994499 hasPublicationYear "2022" @default.
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