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- W4310004310 abstract "Abstract UV‐B‐induced corneal damage remains a challenge in clinics, and it is needed to develop novel and effective medicines against UV‐B induced photodamage. 3,4‐Dihydropyrimidine‐2( 1H )‐thione derivatives have shown many interesting biological activities, including antibacterial, anti‐inflammatory, antioxidant, etc . In order to find a promising anticorneal photodamage agent, we designed and synthesized two novel sulfonated dihydropyrimidinthione derivatives to evaluate cytoprotective effect against UV‐B‐mediated photodamage. With simple structure, compound 6 possessed good water solubility, photostability and biocompatibility. We demonstrated that 6 exhibited significant cytoprotective effects against UV‐B‐mediated photodamage and the cell viability was up to 93% at 0.2 mg mL −1 . The corneal cells were highly sensitive to UV‐B radiation, resulting in the release of inflammatory mediators and DNA damage, which were significantly reversed by 6. Moreover, compound 6 reduced Bax and cleaved Caspase‐3 expressions to suppress UV‐B mediated the intrinsic apoptosis pathway. Our findings suggest that 6 is a promising UV‐B resistant agent with potential to be a promising drug candidate for the treatment of corneal photodamage." @default.
- W4310004310 created "2022-11-30" @default.
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- W4310004310 date "2022-12-27" @default.
- W4310004310 modified "2023-10-18" @default.
- W4310004310 title "Efficient Synthesis and Evaluation of Novel Sulfonated Dihydropyrimidinthione Derivatives for the Treatment of <scp>UV‐B</scp>‐Induced Corneal Damage" @default.
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- W4310004310 doi "https://doi.org/10.1111/php.13748" @default.
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