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- W4310014510 endingPage "215" @default.
- W4310014510 startingPage "196" @default.
- W4310014510 abstract "Chimeric antigen receptor T cell (CAR T cell) therapy is a revolutionary approach approved by the FDA and EMA to treat B cell malignancies and multiple myeloma. The production of these T cells has been done through viral vectors, which come with safety concerns, high cost and production challenges, and more recently also through electroporation, which can be extremely cytotoxic. In this context, nanosystems can constitute an alternative to overcome the challenges associated with current methods, resulting in a safe and cost-effective platform. However, the barriers associated with T cells transfection show that the design and engineering of novel approaches in this field are highly imperative. Here, we present an overview from CAR constitution to transfection technologies used in T cells, highlighting the lipid- and polymer-based nanoparticles as a potential delivery platform. Specifically, we provide examples, strengths and weaknesses of nanosystem formulations, and advances in nanoparticle design to improve transfection of T cells. This review will guide the researchers in the design and development of novel nanosystems for next-generation CAR T therapeutics." @default.
- W4310014510 created "2022-11-30" @default.
- W4310014510 creator A5021453916 @default.
- W4310014510 creator A5038691100 @default.
- W4310014510 creator A5089127267 @default.
- W4310014510 date "2023-01-01" @default.
- W4310014510 modified "2023-10-01" @default.
- W4310014510 title "Polymer- and lipid-based gene delivery technology for CAR T cell therapy" @default.
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