Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310036506> ?p ?o ?g. }
- W4310036506 endingPage "14635" @default.
- W4310036506 startingPage "14635" @default.
- W4310036506 abstract "The amyloid framework forms the central medical theory related to Alzheimer disease (AD), and the in vivo demonstration of amyloid positivity is essential for diagnosing AD. On the basis of a longitudinal cohort design, the study investigated clinical progressive patterns by obtaining cognitive and structural measurements from a group of patients with amnestic mild cognitive impairment (MCI); the measurements were classified by the positivity (Aβ+) or absence (Aβ-) of the amyloid biomarker. We enrolled 185 patients (64 controls, 121 patients with MCI). The patients with MCI were classified into two groups on the basis of their [18F]flubetaben or [18F]florbetapir amyloid positron-emission tomography scan (Aβ+ vs. Aβ-, 67 vs. 54 patients) results. Data from annual cognitive measurements and three-dimensional T1 magnetic resonance imaging scans were used for between-group comparisons. To obtain longitudinal cognitive test scores, generalized estimating equations were applied. A linear mixed effects model was used to compare the time effect of cortical thickness degeneration. The cognitive decline trajectory of the Aβ+ group was obvious, whereas the Aβ- and control groups did not exhibit a noticeable decline over time. The group effects of cortical thickness indicated decreased entorhinal cortex in the Aβ+ group and supramarginal gyrus in the Aβ- group. The topology of neurodegeneration in the Aβ- group was emphasized in posterior cortical regions. A comparison of the changes in the Aβ+ and Aβ- groups over time revealed a higher rate of cortical thickness decline in the Aβ+ group than in the Aβ- group in the default mode network. The Aβ+ and Aβ- groups experienced different APOE ε4 effects. For cortical-cognitive correlations, the regions associated with cognitive decline in the Aβ+ group were mainly localized in the perisylvian and anterior cingulate regions. By contrast, the degenerative topography of Aβ- MCI was scattered. The memory learning curves, cognitive decline patterns, and cortical degeneration topographies of the two MCI groups were revealed to be different, suggesting a difference in pathophysiology. Longitudinal analysis may help to differentiate between these two MCI groups if biomarker access is unavailable in clinical settings." @default.
- W4310036506 created "2022-11-30" @default.
- W4310036506 creator A5008273318 @default.
- W4310036506 creator A5009451103 @default.
- W4310036506 creator A5037290375 @default.
- W4310036506 creator A5037919538 @default.
- W4310036506 creator A5045280648 @default.
- W4310036506 creator A5061521218 @default.
- W4310036506 creator A5062303723 @default.
- W4310036506 creator A5070955009 @default.
- W4310036506 date "2022-11-23" @default.
- W4310036506 modified "2023-09-30" @default.
- W4310036506 title "Impact of Amyloid Pathology in Mild Cognitive Impairment Subjects: The Longitudinal Cognition and Surface Morphometry Data" @default.
- W4310036506 cites W103331225 @default.
- W4310036506 cites W1587329234 @default.
- W4310036506 cites W1833523444 @default.
- W4310036506 cites W1894869667 @default.
- W4310036506 cites W1916233725 @default.
- W4310036506 cites W1970731726 @default.
- W4310036506 cites W1981636437 @default.
- W4310036506 cites W1987777001 @default.
- W4310036506 cites W2019027461 @default.
- W4310036506 cites W2022556750 @default.
- W4310036506 cites W2024311012 @default.
- W4310036506 cites W2026098582 @default.
- W4310036506 cites W2027439132 @default.
- W4310036506 cites W2034968148 @default.
- W4310036506 cites W2057401494 @default.
- W4310036506 cites W2070267512 @default.
- W4310036506 cites W2079309705 @default.
- W4310036506 cites W2079749054 @default.
- W4310036506 cites W2087011519 @default.
- W4310036506 cites W2087924155 @default.
- W4310036506 cites W2110208125 @default.
- W4310036506 cites W2115017507 @default.
- W4310036506 cites W2118117906 @default.
- W4310036506 cites W2125960394 @default.
- W4310036506 cites W2139886607 @default.
- W4310036506 cites W2140470900 @default.
- W4310036506 cites W2159123476 @default.
- W4310036506 cites W2167840686 @default.
- W4310036506 cites W2291435159 @default.
- W4310036506 cites W2494586080 @default.
- W4310036506 cites W2579987562 @default.
- W4310036506 cites W2582524520 @default.
- W4310036506 cites W2599404647 @default.
- W4310036506 cites W2756191472 @default.
- W4310036506 cites W2757720540 @default.
- W4310036506 cites W2767930441 @default.
- W4310036506 cites W2776130467 @default.
- W4310036506 cites W2889504019 @default.
- W4310036506 cites W2904315994 @default.
- W4310036506 cites W2912302682 @default.
- W4310036506 cites W2970328431 @default.
- W4310036506 cites W2990971304 @default.
- W4310036506 cites W3024021250 @default.
- W4310036506 cites W3082702027 @default.
- W4310036506 cites W3131910442 @default.
- W4310036506 cites W3140660898 @default.
- W4310036506 cites W3157186248 @default.
- W4310036506 cites W3203244102 @default.
- W4310036506 cites W4281747958 @default.
- W4310036506 cites W4283527453 @default.
- W4310036506 cites W4292295106 @default.
- W4310036506 doi "https://doi.org/10.3390/ijms232314635" @default.
- W4310036506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36498962" @default.
- W4310036506 hasPublicationYear "2022" @default.
- W4310036506 type Work @default.
- W4310036506 citedByCount "1" @default.
- W4310036506 countsByYear W43100365062023 @default.
- W4310036506 crossrefType "journal-article" @default.
- W4310036506 hasAuthorship W4310036506A5008273318 @default.
- W4310036506 hasAuthorship W4310036506A5009451103 @default.
- W4310036506 hasAuthorship W4310036506A5037290375 @default.
- W4310036506 hasAuthorship W4310036506A5037919538 @default.
- W4310036506 hasAuthorship W4310036506A5045280648 @default.
- W4310036506 hasAuthorship W4310036506A5061521218 @default.
- W4310036506 hasAuthorship W4310036506A5062303723 @default.
- W4310036506 hasAuthorship W4310036506A5070955009 @default.
- W4310036506 hasBestOaLocation W43100365061 @default.
- W4310036506 hasConcept C126322002 @default.
- W4310036506 hasConcept C126838900 @default.
- W4310036506 hasConcept C142724271 @default.
- W4310036506 hasConcept C143409427 @default.
- W4310036506 hasConcept C15744967 @default.
- W4310036506 hasConcept C169760540 @default.
- W4310036506 hasConcept C169900460 @default.
- W4310036506 hasConcept C185592680 @default.
- W4310036506 hasConcept C2775842073 @default.
- W4310036506 hasConcept C2777633098 @default.
- W4310036506 hasConcept C2778373026 @default.
- W4310036506 hasConcept C2779134260 @default.
- W4310036506 hasConcept C2779483572 @default.
- W4310036506 hasConcept C2780715579 @default.
- W4310036506 hasConcept C2781161787 @default.
- W4310036506 hasConcept C2781197716 @default.
- W4310036506 hasConcept C2984863031 @default.
- W4310036506 hasConcept C502032728 @default.