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- W4310052013 abstract "In plants, RNA-directed DNA methylation (RdDM) uses small interfering RNAs (siRNAs) to target transposable elements (TEs) but usually avoids genes. RNA polymerase IV (Pol IV) shapes the landscape of DNA methylation through its pivotal role in siRNA biogenesis. However, how Pol IV is recruited to specific loci, particularly how it avoids genes, is poorly understood. Here, we identified a Pol IV-interacting protein, ZMP (zinc finger, mouse double-minute/switching complex B, Plus-3 protein), which exerts a dual role in regulating siRNA biogenesis and DNA methylation at specific genomic regions. ZMP is required for siRNA biogenesis at some pericentromeric regions and prevents Pol IV from targeting a subset of TEs and genes at euchromatic loci. As a chromatin-associated protein, ZMP prefers regions with depleted histone H3 lysine 4 (H3K4) methylation abutted by regions with H3K4 methylation, probably monitoring changes in local H3K4 methylation status to regulate Pol IV's chromatin occupancy. Our findings uncover a mechanism governing the specificity of RdDM." @default.
- W4310052013 created "2022-11-30" @default.
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- W4310052013 date "2022-11-25" @default.
- W4310052013 modified "2023-10-14" @default.
- W4310052013 title "ZMP recruits and excludes Pol IV–mediated DNA methylation in a site-specific manner" @default.
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- W4310052013 doi "https://doi.org/10.1126/sciadv.adc9454" @default.
- W4310052013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36427317" @default.
- W4310052013 hasPublicationYear "2022" @default.
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