FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310054754> ?p ?o ?g. }

• W4310054754 endingPage "333" @default.
• W4310054754 startingPage "327" @default.
• W4310054754 abstract "Introduction: Little is known regarding peripheral blood mononuclear cell telomere length (PBMC-TL) and response to traumatic injury. The objective of this study was to characterize the role of PBMC-TL in coagulation and clinical outcomes after injury. Methods: Plasma and buffy coats were prospectively collected from trauma patients and healthy volunteers. DNA was purified and PBMC-TL quantified by quantitative polymerase chain reaction. Thrombin generation kinetics were expressed as lag time (in minutes), peak height (in nanometers), time to peak (in minutes), and endogenous thrombin potential (in nM × min). Results are in median and quartiles [Q1, Q3]. P < 0.05 was considered significant (Wilcoxon rank sum testing). Results: Forty-two younger patients (21 [20, 22] years, 69% were male) and 39 older patients (62 [61, 64] years, 79% were male) were included. There was no significant difference in Clinical Frailty Scores between groups. Younger patients had longer total PBMC-TL (0.40 Mb [0.30, 0.49] vs. 0.29 Mb [0.23, 0.33], P < 0.001) and longer average PBMC-TL per chromosome (4.3 kb [3.3, 5.3] vs. 3.2 kb [2.5, 3.7], P < 0.001). When older patients were stratified by 50th percentile of PBMC-TL, there were no differences in thrombin generation; however, those with shorter telomeres were less likely to be discharged home (29% vs. 77%, P = 0.004). Older patients in the bottom quartile of PBMC-TL had shorter lag time (2.78 min [2.33, 3.00] vs. 3.33 min [3.24, 3.89], P = 0.030) and were less likely to be discharged home (22% vs. 90%, P = 0.006) than those in the top quartile of PBMC-TL. Multivariable logistic regression models revealed both increased age and shorter PBMC-TL to be independent predictors of discharge disposition other than home. Conclusion: In older trauma patients, shorter PBMC-TL is associated with accelerated initiation of thrombin generation and lower likelihood of being discharged to home." @default.
• W4310054754 created "2022-11-30" @default.
• W4310054754 creator A5003206975 @default.
• W4310054754 creator A5008891082 @default.
• W4310054754 creator A5010537534 @default.
• W4310054754 creator A5014513490 @default.
• W4310054754 creator A5022328904 @default.
• W4310054754 creator A5029198859 @default.
• W4310054754 creator A5032572850 @default.
• W4310054754 creator A5033016169 @default.
• W4310054754 creator A5037957960 @default.
• W4310054754 creator A5042453366 @default.
• W4310054754 creator A5047033692 @default.
• W4310054754 creator A5061388624 @default.
• W4310054754 creator A5073698059 @default.
• W4310054754 date "2022-11-26" @default.
• W4310054754 modified "2023-09-26" @default.
• W4310054754 title "TELOMERE LENGTH OF PERIPHERAL BLOOD MONONUCLEAR CELLS IS ASSOCIATED WITH DISCHARGE DISPOSITION IN OLDER TRAUMA PATIENTS" @default.
• W4310054754 cites W2026180657 @default.
• W4310054754 cites W2041397478 @default.
• W4310054754 cites W2042000503 @default.
• W4310054754 cites W2068367301 @default.
• W4310054754 cites W2087391363 @default.
• W4310054754 cites W2090371144 @default.
• W4310054754 cites W2094327837 @default.
• W4310054754 cites W2095982855 @default.
• W4310054754 cites W2129198998 @default.
• W4310054754 cites W2144787350 @default.
• W4310054754 cites W2164059021 @default.
• W4310054754 cites W2170979068 @default.
• W4310054754 cites W2208667142 @default.
• W4310054754 cites W2266438109 @default.
• W4310054754 cites W2602208455 @default.
• W4310054754 cites W2602456488 @default.
• W4310054754 cites W2603248644 @default.
• W4310054754 cites W2782002212 @default.
• W4310054754 cites W2918905074 @default.
• W4310054754 cites W2948285318 @default.
• W4310054754 cites W2966234296 @default.
• W4310054754 cites W2972212509 @default.
• W4310054754 cites W3006133913 @default.
• W4310054754 cites W3081828321 @default.
• W4310054754 cites W3084920978 @default.
• W4310054754 cites W3124758554 @default.
• W4310054754 cites W3126771781 @default.
• W4310054754 cites W3211160510 @default.
• W4310054754 cites W4220980680 @default.
• W4310054754 cites W4224055822 @default.
• W4310054754 cites W4224316674 @default.
• W4310054754 cites W4239266518 @default.
• W4310054754 cites W4240056188 @default.
• W4310054754 cites W4243177118 @default.
• W4310054754 cites W4367329936 @default.
• W4310054754 doi "https://doi.org/10.1097/shk.0000000000002059" @default.
• W4310054754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36427074" @default.
• W4310054754 hasPublicationYear "2022" @default.
• W4310054754 type Work @default.
• W4310054754 citedByCount "1" @default.
• W4310054754 countsByYear W43100547542023 @default.
• W4310054754 crossrefType "journal-article" @default.
• W4310054754 hasAuthorship W4310054754A5003206975 @default.
• W4310054754 hasAuthorship W4310054754A5008891082 @default.
• W4310054754 hasAuthorship W4310054754A5010537534 @default.
• W4310054754 hasAuthorship W4310054754A5014513490 @default.
• W4310054754 hasAuthorship W4310054754A5022328904 @default.
• W4310054754 hasAuthorship W4310054754A5029198859 @default.
• W4310054754 hasAuthorship W4310054754A5032572850 @default.
• W4310054754 hasAuthorship W4310054754A5033016169 @default.
• W4310054754 hasAuthorship W4310054754A5037957960 @default.
• W4310054754 hasAuthorship W4310054754A5042453366 @default.
• W4310054754 hasAuthorship W4310054754A5047033692 @default.
• W4310054754 hasAuthorship W4310054754A5061388624 @default.
• W4310054754 hasAuthorship W4310054754A5073698059 @default.
• W4310054754 hasConcept C126322002 @default.
• W4310054754 hasConcept C137061746 @default.
• W4310054754 hasConcept C16685009 @default.
• W4310054754 hasConcept C177336024 @default.
• W4310054754 hasConcept C202751555 @default.
• W4310054754 hasConcept C203014093 @default.
• W4310054754 hasConcept C44249647 @default.
• W4310054754 hasConcept C54355233 @default.
• W4310054754 hasConcept C552990157 @default.
• W4310054754 hasConcept C55493867 @default.
• W4310054754 hasConcept C68443243 @default.
• W4310054754 hasConcept C71924100 @default.
• W4310054754 hasConcept C86803240 @default.
• W4310054754 hasConcept C90924648 @default.
• W4310054754 hasConceptScore W4310054754C126322002 @default.
• W4310054754 hasConceptScore W4310054754C137061746 @default.
• W4310054754 hasConceptScore W4310054754C16685009 @default.
• W4310054754 hasConceptScore W4310054754C177336024 @default.
• W4310054754 hasConceptScore W4310054754C202751555 @default.
• W4310054754 hasConceptScore W4310054754C203014093 @default.
• W4310054754 hasConceptScore W4310054754C44249647 @default.
• W4310054754 hasConceptScore W4310054754C54355233 @default.
• W4310054754 hasConceptScore W4310054754C552990157 @default.
• W4310054754 hasConceptScore W4310054754C55493867 @default.
• W4310054754 hasConceptScore W4310054754C68443243 @default.

• next