Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310066464> ?p ?o ?g. }
- W4310066464 endingPage "1522" @default.
- W4310066464 startingPage "1515" @default.
- W4310066464 abstract "Zn (II) complexes of Schiff bases have potential applications in biomedical sciences as imaging agents, cancer therapeutics and diagnostics. Thus, it is important to understand their interaction with carrier proteins, like serum albumins. The present paper focuses on the binding interactions between Human serum albumin (HSA) and Znsalampy, making use of fluorescence spectroscopic techniques at ensemble as well as at single molecular level. An idea about the binding constant is obtained from the quenching of the single Trp (Tryptophan) residue of HSA by Znsalampy. Fluorescence correlation spectroscopy (FCS) has also been used to monitor the protein-ligand binding. The location of Znsalampy in its complex with HSA is determined by competitive binding experiments and molecular docking calculations. The binding constant obtained from the Znsalampy-HSA interaction falls in the ideal range for biological applications and the location is found to be in the proximity of Sudlow's site I. The esterase activity of HSA is retained in the presence of the Znsalampy. Hence, it is concluded that this Znsalampy may be a potential probe and biomarker in biomedical applications." @default.
- W4310066464 created "2022-11-30" @default.
- W4310066464 creator A5003843923 @default.
- W4310066464 creator A5035863623 @default.
- W4310066464 creator A5073451779 @default.
- W4310066464 creator A5086841552 @default.
- W4310066464 date "2023-01-01" @default.
- W4310066464 modified "2023-10-18" @default.
- W4310066464 title "Fluorescence monitoring of binding of a Zn (II) complex of a Schiff base with human serum albumin" @default.
- W4310066464 cites W1973153850 @default.
- W4310066464 cites W1982903692 @default.
- W4310066464 cites W1984880199 @default.
- W4310066464 cites W1986499818 @default.
- W4310066464 cites W1990157913 @default.
- W4310066464 cites W1991411602 @default.
- W4310066464 cites W2000657088 @default.
- W4310066464 cites W2007107123 @default.
- W4310066464 cites W2011764481 @default.
- W4310066464 cites W2015125205 @default.
- W4310066464 cites W2020188049 @default.
- W4310066464 cites W2023082812 @default.
- W4310066464 cites W2023362867 @default.
- W4310066464 cites W2042198272 @default.
- W4310066464 cites W2043109896 @default.
- W4310066464 cites W2048120157 @default.
- W4310066464 cites W2061855305 @default.
- W4310066464 cites W2070555975 @default.
- W4310066464 cites W2073626515 @default.
- W4310066464 cites W2081908525 @default.
- W4310066464 cites W2082282510 @default.
- W4310066464 cites W2095558685 @default.
- W4310066464 cites W2127492503 @default.
- W4310066464 cites W2241099034 @default.
- W4310066464 cites W2570963991 @default.
- W4310066464 cites W2590339109 @default.
- W4310066464 cites W2606537295 @default.
- W4310066464 cites W2746735161 @default.
- W4310066464 cites W2747987033 @default.
- W4310066464 cites W2751611403 @default.
- W4310066464 cites W2765114937 @default.
- W4310066464 cites W2778326339 @default.
- W4310066464 cites W2890398765 @default.
- W4310066464 cites W2901516736 @default.
- W4310066464 cites W2917035008 @default.
- W4310066464 cites W2931078281 @default.
- W4310066464 cites W2932166343 @default.
- W4310066464 cites W2945306972 @default.
- W4310066464 cites W2949771713 @default.
- W4310066464 cites W2972689556 @default.
- W4310066464 cites W2984583074 @default.
- W4310066464 cites W2998115264 @default.
- W4310066464 cites W3014281134 @default.
- W4310066464 cites W3109218211 @default.
- W4310066464 cites W3125759541 @default.
- W4310066464 cites W3158827182 @default.
- W4310066464 cites W3165743133 @default.
- W4310066464 cites W3179954863 @default.
- W4310066464 cites W3186215972 @default.
- W4310066464 cites W3188982918 @default.
- W4310066464 cites W3194591954 @default.
- W4310066464 cites W3203503346 @default.
- W4310066464 cites W3207164785 @default.
- W4310066464 cites W3215402655 @default.
- W4310066464 cites W4280613601 @default.
- W4310066464 cites W4281285645 @default.
- W4310066464 cites W4282588488 @default.
- W4310066464 cites W4284881295 @default.
- W4310066464 cites W4290667683 @default.
- W4310066464 cites W4291280592 @default.
- W4310066464 doi "https://doi.org/10.1016/j.ijbiomac.2022.11.263" @default.
- W4310066464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36442551" @default.
- W4310066464 hasPublicationYear "2023" @default.
- W4310066464 type Work @default.
- W4310066464 citedByCount "1" @default.
- W4310066464 countsByYear W43100664642023 @default.
- W4310066464 crossrefType "journal-article" @default.
- W4310066464 hasAuthorship W4310066464A5003843923 @default.
- W4310066464 hasAuthorship W4310066464A5035863623 @default.
- W4310066464 hasAuthorship W4310066464A5073451779 @default.
- W4310066464 hasAuthorship W4310066464A5086841552 @default.
- W4310066464 hasConcept C107824862 @default.
- W4310066464 hasConcept C121332964 @default.
- W4310066464 hasConcept C12554922 @default.
- W4310066464 hasConcept C158711907 @default.
- W4310066464 hasConcept C159110408 @default.
- W4310066464 hasConcept C165616093 @default.
- W4310066464 hasConcept C185592680 @default.
- W4310066464 hasConcept C21951064 @default.
- W4310066464 hasConcept C2776428424 @default.
- W4310066464 hasConcept C2776706248 @default.
- W4310066464 hasConcept C2778597219 @default.
- W4310066464 hasConcept C32786932 @default.
- W4310066464 hasConcept C41685203 @default.
- W4310066464 hasConcept C515207424 @default.
- W4310066464 hasConcept C55493867 @default.
- W4310066464 hasConcept C62520636 @default.
- W4310066464 hasConcept C71240020 @default.
- W4310066464 hasConcept C71924100 @default.