Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310075509> ?p ?o ?g. }
- W4310075509 endingPage "101128" @default.
- W4310075509 startingPage "101128" @default.
- W4310075509 abstract "The current knowledge on biological effects associated with proton therapy is limited. Therefore, we investigated the distributions of dose, dose-averaged linear energy transfer (LETd), and the product between dose and LETd (DLETd) for a patient cohort treated with proton therapy. Different treatment planning system features and visualization tools were explored.For a cohort of 24 patients with brain tumors, the LETd, DLETd, and dose was calculated for a fixed relative biological effectiveness value and 2 variable models: plan-based and phenomenological. Dose threshold levels of 0, 5, and 20 Gy were imposed for LETd visualization. The relationship between physical dose and LETd and the frequency of LETd hotspots were investigated.The phenomenological relative biological effectiveness model presented consistently higher dose values. For lower dose thresholds, the LETd distribution was steered toward higher values related to low treatment doses. Differences up to 26.0% were found according to the threshold. Maximum LETd values were identified in the brain, periventricular space, and ventricles. An inverse relationship between LETd and dose was observed. Frequency information to the domain of dose and LETd allowed for the identification of clusters, which steer the mean LETd values, and the identification of higher, but sparse, LETd values.Identifying, quantifying, and recording LET distributions in a standardized fashion is necessary, because concern exists over a link between toxicity and LET hotspots. Visualizing DLETd or dose × LETd during treatment planning could allow for clinicians to make informed decisions." @default.
- W4310075509 created "2022-11-30" @default.
- W4310075509 creator A5000224213 @default.
- W4310075509 creator A5005758843 @default.
- W4310075509 creator A5019338813 @default.
- W4310075509 creator A5031250960 @default.
- W4310075509 creator A5042890693 @default.
- W4310075509 creator A5043460124 @default.
- W4310075509 creator A5057987192 @default.
- W4310075509 creator A5060701646 @default.
- W4310075509 date "2023-03-01" @default.
- W4310075509 modified "2023-10-01" @default.
- W4310075509 title "Linear Energy Transfer and Relative Biological Effectiveness Investigation of Various Structures for a Cohort of Proton Patients With Brain Tumors" @default.
- W4310075509 cites W1923055195 @default.
- W4310075509 cites W1968042369 @default.
- W4310075509 cites W2030688434 @default.
- W4310075509 cites W2041126697 @default.
- W4310075509 cites W2083770395 @default.
- W4310075509 cites W2116345430 @default.
- W4310075509 cites W2154519202 @default.
- W4310075509 cites W2158918353 @default.
- W4310075509 cites W2287874371 @default.
- W4310075509 cites W2509332681 @default.
- W4310075509 cites W2513819086 @default.
- W4310075509 cites W2521454359 @default.
- W4310075509 cites W2550452995 @default.
- W4310075509 cites W2606164991 @default.
- W4310075509 cites W2611950122 @default.
- W4310075509 cites W2745534020 @default.
- W4310075509 cites W2745603711 @default.
- W4310075509 cites W2766241933 @default.
- W4310075509 cites W2770989174 @default.
- W4310075509 cites W2783983963 @default.
- W4310075509 cites W2794514924 @default.
- W4310075509 cites W2800649452 @default.
- W4310075509 cites W2804715948 @default.
- W4310075509 cites W2806887767 @default.
- W4310075509 cites W2809228552 @default.
- W4310075509 cites W2885829702 @default.
- W4310075509 cites W2888688605 @default.
- W4310075509 cites W2898672813 @default.
- W4310075509 cites W2901333539 @default.
- W4310075509 cites W2908570353 @default.
- W4310075509 cites W2912650118 @default.
- W4310075509 cites W2960522134 @default.
- W4310075509 cites W2967838257 @default.
- W4310075509 cites W2971981779 @default.
- W4310075509 cites W3002590463 @default.
- W4310075509 cites W3013098905 @default.
- W4310075509 cites W3034433855 @default.
- W4310075509 cites W3045397057 @default.
- W4310075509 cites W3083406506 @default.
- W4310075509 cites W3095994286 @default.
- W4310075509 cites W3098202381 @default.
- W4310075509 cites W3118902480 @default.
- W4310075509 cites W3124619990 @default.
- W4310075509 cites W3153012148 @default.
- W4310075509 cites W3160274128 @default.
- W4310075509 cites W3176172708 @default.
- W4310075509 cites W3177472345 @default.
- W4310075509 cites W3194262682 @default.
- W4310075509 cites W3196287211 @default.
- W4310075509 cites W3208549150 @default.
- W4310075509 cites W4281989121 @default.
- W4310075509 cites W4285508994 @default.
- W4310075509 cites W4292763520 @default.
- W4310075509 doi "https://doi.org/10.1016/j.adro.2022.101128" @default.
- W4310075509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36632089" @default.
- W4310075509 hasPublicationYear "2023" @default.
- W4310075509 type Work @default.
- W4310075509 citedByCount "3" @default.
- W4310075509 countsByYear W43100755092023 @default.
- W4310075509 crossrefType "journal-article" @default.
- W4310075509 hasAuthorship W4310075509A5000224213 @default.
- W4310075509 hasAuthorship W4310075509A5005758843 @default.
- W4310075509 hasAuthorship W4310075509A5019338813 @default.
- W4310075509 hasAuthorship W4310075509A5031250960 @default.
- W4310075509 hasAuthorship W4310075509A5042890693 @default.
- W4310075509 hasAuthorship W4310075509A5043460124 @default.
- W4310075509 hasAuthorship W4310075509A5057987192 @default.
- W4310075509 hasAuthorship W4310075509A5060701646 @default.
- W4310075509 hasBestOaLocation W43100755091 @default.
- W4310075509 hasConcept C121332964 @default.
- W4310075509 hasConcept C126322002 @default.
- W4310075509 hasConcept C153385146 @default.
- W4310075509 hasConcept C185544564 @default.
- W4310075509 hasConcept C2989005 @default.
- W4310075509 hasConcept C54516573 @default.
- W4310075509 hasConcept C71924100 @default.
- W4310075509 hasConcept C72563966 @default.
- W4310075509 hasConcept C86611320 @default.
- W4310075509 hasConceptScore W4310075509C121332964 @default.
- W4310075509 hasConceptScore W4310075509C126322002 @default.
- W4310075509 hasConceptScore W4310075509C153385146 @default.
- W4310075509 hasConceptScore W4310075509C185544564 @default.
- W4310075509 hasConceptScore W4310075509C2989005 @default.
- W4310075509 hasConceptScore W4310075509C54516573 @default.
- W4310075509 hasConceptScore W4310075509C71924100 @default.