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- W4310080476 abstract "With advances in drug development and our understanding of the pathophysiology of skin disease, biologic medications have emerged as powerful management tools for dermatologists. While biologics have most often been used in the management of psoriasis, they are being used off-label for the management of a variety of other immune-mediated skin diseases with overlapping molecular targets. This narrative review focuses on the novel and off-label use of biologic medications for the management of hidradenitis suppurativa (HS), pyoderma gangrenosum (PG), lichen planus (LP), and seborrheic dermatitis (SD). Review of the literature revealed that IL-17, IL-23, and tumor necrosis factor (TNF) inhibitors were being used across a variety of immune-mediated skin pathologies with variable efficacy, among other targeted biologics. While biologics were generally safe in the treatment of primary immune-mediated skin disorders, paradoxical disease eruptions were noted with biologic use and were theorized to occur owing to immune dysregulation and cytokine imbalance. While numerous case reports show promise for the use of biologics in immune-mediated skin pathologies, the variable efficacy and safety reported warrants more thorough investigations of the role of these targeted medications in comprehensive disease management." @default.
- W4310080476 created "2022-11-30" @default.
- W4310080476 creator A5025181865 @default.
- W4310080476 creator A5025751038 @default.
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- W4310080476 creator A5059707925 @default.
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- W4310080476 creator A5081159393 @default.
- W4310080476 creator A5081366253 @default.
- W4310080476 creator A5059763880 @default.
- W4310080476 date "2022-11-25" @default.
- W4310080476 modified "2023-10-09" @default.
- W4310080476 title "Novel and Off-Label Biologic Use in the Management of Hidradenitis Suppurativa, Pyoderma Gangrenosum, Lichen Planus, and Seborrheic Dermatitis: A Narrative Review" @default.
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- W4310080476 doi "https://doi.org/10.1007/s13555-022-00860-5" @default.