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- W4310082818 abstract "Abstract Introduction This study assessed the associations of multimorbidity burden and its developmental trajectory with later‐life dementia. Methods Among 5923 Health and Retirement Study participants, major chronic conditions including hypertension, diabetes mellitus, cancer, lung diseases, heart disease, stroke, psychological disorders, and arthritis were self‐ or proxy‐reported in 1994‐2008. Dementia diagnosis was self‐ or proxy‐reported in 2008‐2018. We used Cox regression to assess the associations of multimorbidity with incident dementia. Results During follow‐up (median = 8 years), 701 participants developed dementia. Each additional chronic condition in 2008 was related to 15% (confidence interval: 9% to 22%) higher hazard of dementia. Multimorbidity trajectories in 1994‐2008 were classified as “rapid growth”, “steady growth”, “slow growth”, and “no new condition” by the group‐based trajectory modelling methods. Compared to “no new condition”, the “rapid growth” trajectory was related to 32% (3% to 69%) higher dementia risk. Conclusions Both multimorbidity burden and its developmental trajectory were prospectively associated with risk of dementia." @default.
- W4310082818 created "2022-11-30" @default.
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- W4310082818 date "2022-11-25" @default.
- W4310082818 modified "2023-10-12" @default.
- W4310082818 title "Multimorbidity burden and developmental trajectory in relation to later‐life dementia: A prospective study" @default.
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- W4310082818 doi "https://doi.org/10.1002/alz.12840" @default.
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