FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310089838> ?p ?o ?g. }

• W4310089838 endingPage "e1010701" @default.
• W4310089838 startingPage "e1010701" @default.
• W4310089838 abstract "Physiological and pathological processes including embryogenesis and tumorigenesis rely on the ability of individual cells to work collectively to form multicell patterns. In these heterogeneous multicell systems, cell-cell signaling induces differential adhesion between cells that leads to tissue-level patterning. However, the sensitivity of pattern formation to changes in the strengths of signaling or cell adhesion processes is not well understood. Prior work has explored these issues using synthetically engineered heterogeneous multicell spheroid systems, in which cell subpopulations engage in bidirectional intercellular signaling to regulate the expression of different cadherins. While engineered cell systems provide excellent experimental tools to observe pattern formation in cell populations, computational models of these systems may be leveraged to explore more systematically how specific combinations of signaling and adhesion parameters can drive the emergence of unique patterns. We developed and validated two- and three-dimensional agent-based models (ABMs) of spheroid patterning for previously described cells engineered with a bidirectional signaling circuit that regulates N- and P-cadherin expression. Systematic exploration of model predictions, some of which were experimentally validated, revealed how cell seeding parameters, the order of signaling events, probabilities of induced cadherin expression, and homotypic adhesion strengths affect pattern formation. Unsupervised clustering was also used to map combinations of signaling and adhesion parameters to these unique spheroid patterns predicted by the ABM. Finally, we demonstrated how the model may be deployed to design new synthetic cell signaling circuits based on a desired final multicell pattern." @default.
• W4310089838 created "2022-11-30" @default.
• W4310089838 creator A5004292544 @default.
• W4310089838 creator A5017480661 @default.
• W4310089838 creator A5086441986 @default.
• W4310089838 creator A5089369638 @default.
• W4310089838 date "2022-11-28" @default.
• W4310089838 modified "2023-09-30" @default.
• W4310089838 title "A computational modeling approach for predicting multicell spheroid patterns based on signaling-induced differential adhesion" @default.
• W4310089838 cites W1970680825 @default.
• W4310089838 cites W1976872126 @default.
• W4310089838 cites W1977624796 @default.
• W4310089838 cites W1977973890 @default.
• W4310089838 cites W1978609854 @default.
• W4310089838 cites W1980482491 @default.
• W4310089838 cites W1983208899 @default.
• W4310089838 cites W1985072454 @default.
• W4310089838 cites W1988893861 @default.
• W4310089838 cites W2001114745 @default.
• W4310089838 cites W2006433225 @default.
• W4310089838 cites W2012583790 @default.
• W4310089838 cites W2019214567 @default.
• W4310089838 cites W2020644315 @default.
• W4310089838 cites W2030699054 @default.
• W4310089838 cites W2030944887 @default.
• W4310089838 cites W2031876645 @default.
• W4310089838 cites W2036828218 @default.
• W4310089838 cites W2049102046 @default.
• W4310089838 cites W2064515627 @default.
• W4310089838 cites W2065191902 @default.
• W4310089838 cites W2066416662 @default.
• W4310089838 cites W2078415101 @default.
• W4310089838 cites W2091236590 @default.
• W4310089838 cites W2103852413 @default.
• W4310089838 cites W2104101394 @default.
• W4310089838 cites W2105135903 @default.
• W4310089838 cites W2111020654 @default.
• W4310089838 cites W2111072594 @default.
• W4310089838 cites W2114952275 @default.
• W4310089838 cites W2115046038 @default.
• W4310089838 cites W2117933964 @default.
• W4310089838 cites W2120791255 @default.
• W4310089838 cites W2123118520 @default.
• W4310089838 cites W2124688359 @default.
• W4310089838 cites W2127225632 @default.
• W4310089838 cites W2146335969 @default.
• W4310089838 cites W2148239387 @default.
• W4310089838 cites W2150670229 @default.
• W4310089838 cites W2151876618 @default.
• W4310089838 cites W2154209639 @default.
• W4310089838 cites W2157999920 @default.
• W4310089838 cites W2161045785 @default.
• W4310089838 cites W2169137217 @default.
• W4310089838 cites W2196686104 @default.
• W4310089838 cites W2220114634 @default.
• W4310089838 cites W2256857837 @default.
• W4310089838 cites W2264879763 @default.
• W4310089838 cites W2296873124 @default.
• W4310089838 cites W2398580931 @default.
• W4310089838 cites W2473985047 @default.
• W4310089838 cites W2594149526 @default.
• W4310089838 cites W2735617848 @default.
• W4310089838 cites W2736845755 @default.
• W4310089838 cites W2770668003 @default.
• W4310089838 cites W2797931455 @default.
• W4310089838 cites W2806766210 @default.
• W4310089838 cites W2808367373 @default.
• W4310089838 cites W2885404336 @default.
• W4310089838 cites W2906067435 @default.
• W4310089838 cites W2916359453 @default.
• W4310089838 cites W2936354951 @default.
• W4310089838 cites W2951213949 @default.
• W4310089838 cites W2951856423 @default.
• W4310089838 cites W2953057790 @default.
• W4310089838 cites W2974568541 @default.
• W4310089838 cites W2990186364 @default.
• W4310089838 cites W2991126964 @default.
• W4310089838 cites W2996109087 @default.
• W4310089838 cites W2999769614 @default.
• W4310089838 cites W3087361692 @default.
• W4310089838 cites W3093183764 @default.
• W4310089838 cites W3099981825 @default.
• W4310089838 cites W3100368092 @default.
• W4310089838 cites W3117751160 @default.
• W4310089838 cites W3169788139 @default.
• W4310089838 cites W3214389602 @default.
• W4310089838 cites W4366766759 @default.
• W4310089838 cites W91582749 @default.
• W4310089838 doi "https://doi.org/10.1371/journal.pcbi.1010701" @default.
• W4310089838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36441822" @default.
• W4310089838 hasPublicationYear "2022" @default.
• W4310089838 type Work @default.
• W4310089838 citedByCount "1" @default.
• W4310089838 countsByYear W43100898382023 @default.
• W4310089838 crossrefType "journal-article" @default.
• W4310089838 hasAuthorship W4310089838A5004292544 @default.
• W4310089838 hasAuthorship W4310089838A5017480661 @default.
• W4310089838 hasAuthorship W4310089838A5086441986 @default.

• next