FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310102487> ?p ?o ?g. }

• W4310102487 abstract "Remodeling of the uterine vasculature by invasive extravillous trophoblasts (EVTs) is a critical aspect of human placentation. Insufficient EVT invasion can lead to severe obstetrical complications like preeclampsia, intrauterine growth restriction, and preterm birth. Glial cells missing-1 (GCM1) is a transcription factor that is crucial for proper placentation in mice, and is highly expressed in human syncytiotrophoblast (ST) and EVTs. GCM1 is classically considered a master regulator of ST formation, but little is known about its contribution to the development and function of EVTs. Therefore, in this study we test the hypothesis that GCM1 is a critical regulator of both EVT and ST development and function. We show that GCM1 is highly expressed in human trophoblast stem (TS) cells differentiated into either ST or EVTs. Knockdown of GCM1 in TS cells hindered differentiation into both ST and EVT pathways. When placed in ST media, GCM1-knockdown cells formed small, unstable clusters; when placed in EVT media, cells had altered morphology and transcript profiles resembling cells trapped in an intermediate state between CT and EVT, and invasive capacity through matrix was reduced. RNA sequencing analysis of GCM1-deficient TS cells revealed downregulation of EVT-associated genes and enrichment in transcripts related to WNT signaling, which was linked to decreased expression of the EVT master regulator ASCL2 and the WNT antagonist NOTUM. Our findings reveal an essential role of GCM1 during ST and EVT development, and suggest that GCM1 regulates differentiation of human TS cells into EVTs by inducing expression of ASCL2 and NOTUM." @default.
• W4310102487 created "2022-11-30" @default.
• W4310102487 creator A5006940359 @default.
• W4310102487 creator A5008772402 @default.
• W4310102487 creator A5029927234 @default.
• W4310102487 creator A5042925964 @default.
• W4310102487 creator A5049261041 @default.
• W4310102487 creator A5067257359 @default.
• W4310102487 creator A5078106567 @default.
• W4310102487 creator A5082684607 @default.
• W4310102487 creator A5083945691 @default.
• W4310102487 creator A5090025641 @default.
• W4310102487 date "2022-11-28" @default.
• W4310102487 modified "2023-10-14" @default.
• W4310102487 title "The multifaceted role of GCM1 during trophoblast differentiation in the human placenta" @default.
• W4310102487 cites W1487146757 @default.
• W4310102487 cites W1963765620 @default.
• W4310102487 cites W1964485346 @default.
• W4310102487 cites W1969206395 @default.
• W4310102487 cites W1969717239 @default.
• W4310102487 cites W1974091584 @default.
• W4310102487 cites W1995046740 @default.
• W4310102487 cites W2007226687 @default.
• W4310102487 cites W2013438278 @default.
• W4310102487 cites W2038027186 @default.
• W4310102487 cites W2040284079 @default.
• W4310102487 cites W2054924479 @default.
• W4310102487 cites W2056791306 @default.
• W4310102487 cites W2066076664 @default.
• W4310102487 cites W2086455816 @default.
• W4310102487 cites W2094043939 @default.
• W4310102487 cites W2109815830 @default.
• W4310102487 cites W2112391875 @default.
• W4310102487 cites W2123101895 @default.
• W4310102487 cites W2125904354 @default.
• W4310102487 cites W2136479099 @default.
• W4310102487 cites W2151718079 @default.
• W4310102487 cites W2154307309 @default.
• W4310102487 cites W2166709616 @default.
• W4310102487 cites W2172035437 @default.
• W4310102487 cites W2577081443 @default.
• W4310102487 cites W2584957827 @default.
• W4310102487 cites W2613602651 @default.
• W4310102487 cites W2620868867 @default.
• W4310102487 cites W2624294290 @default.
• W4310102487 cites W2767035310 @default.
• W4310102487 cites W2775775321 @default.
• W4310102487 cites W2779724239 @default.
• W4310102487 cites W2792448726 @default.
• W4310102487 cites W2800852900 @default.
• W4310102487 cites W2803307082 @default.
• W4310102487 cites W2886227808 @default.
• W4310102487 cites W2887483703 @default.
• W4310102487 cites W2894011049 @default.
• W4310102487 cites W2900144939 @default.
• W4310102487 cites W2901367000 @default.
• W4310102487 cites W2903489697 @default.
• W4310102487 cites W2942777904 @default.
• W4310102487 cites W2959369889 @default.
• W4310102487 cites W2973774575 @default.
• W4310102487 cites W2988571942 @default.
• W4310102487 cites W2990237704 @default.
• W4310102487 cites W3009496841 @default.
• W4310102487 cites W3038613768 @default.
• W4310102487 cites W3135276664 @default.
• W4310102487 cites W3164878902 @default.
• W4310102487 cites W3167094961 @default.
• W4310102487 cites W4206619080 @default.
• W4310102487 cites W4220815687 @default.
• W4310102487 cites W4229459765 @default.
• W4310102487 cites W4286209806 @default.
• W4310102487 cites W4286632107 @default.
• W4310102487 doi "https://doi.org/10.1073/pnas.2203071119" @default.
• W4310102487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36442132" @default.
• W4310102487 hasPublicationYear "2022" @default.
• W4310102487 type Work @default.
• W4310102487 citedByCount "6" @default.
• W4310102487 countsByYear W43101024872023 @default.
• W4310102487 crossrefType "journal-article" @default.
• W4310102487 hasAuthorship W4310102487A5006940359 @default.
• W4310102487 hasAuthorship W4310102487A5008772402 @default.
• W4310102487 hasAuthorship W4310102487A5029927234 @default.
• W4310102487 hasAuthorship W4310102487A5042925964 @default.
• W4310102487 hasAuthorship W4310102487A5049261041 @default.
• W4310102487 hasAuthorship W4310102487A5067257359 @default.
• W4310102487 hasAuthorship W4310102487A5078106567 @default.
• W4310102487 hasAuthorship W4310102487A5082684607 @default.
• W4310102487 hasAuthorship W4310102487A5083945691 @default.
• W4310102487 hasAuthorship W4310102487A5090025641 @default.
• W4310102487 hasBestOaLocation W43101024871 @default.
• W4310102487 hasConcept C104317684 @default.
• W4310102487 hasConcept C127561419 @default.
• W4310102487 hasConcept C137620995 @default.
• W4310102487 hasConcept C16685009 @default.
• W4310102487 hasConcept C172680121 @default.
• W4310102487 hasConcept C173396325 @default.
• W4310102487 hasConcept C2776953305 @default.
• W4310102487 hasConcept C2777495146 @default.
• W4310102487 hasConcept C2779234561 @default.
• W4310102487 hasConcept C45167389 @default.

• next