FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310112198> ?p ?o ?g. }

• W4310112198 endingPage "5864" @default.
• W4310112198 startingPage "5854" @default.
• W4310112198 abstract "Abnormal levels (high/low) of urinary human serum albumin (HSA) are associated with a number of diseases and thus act as an essential biomarker for quick therapeutic monitoring and biomedical diagnosis, entailing the urgent development of an effective chemosensor to quantify the albumin levels. Herein, we have rationally designed and developed a small fluorogenic molecular probe, (Z)-2-(5-((8-hydroxy-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-9-yl) methylene)-4-oxo-2-thioxothiazolidin-3-yl) acetic acid (HJRA) with a twisted intramolecular charge transfer (TICT) property, which can easily self-assemble into nonfluorescent nanoaggregates in aqueous solution. However, HJRA nanoaggregates can selectively bind with serum albumin proteins (HSA/BSA) in ∼100% PBS medium, thereby facilitating the disassembly of nanoaggregates into monomers, exhibiting a clear turn-on red fluorescent response toward HSA and BSA. Analysis of the specific binding mechanism between HJRA and HSA using a site-selective fluorescence displacement assay and molecular docking simulations indicates that a variety of noncovalent interactions are responsible for the disassembly of nanoaggregates with the concomitant trapping of the HJRA monomer at site I in HSA, yielding a substantial red emission caused by the inhibition of intramolecular rotation of HJRA probe inside the hydrophobic cavity of HSA. The limit of detection (LOD) determined by the 3σ/slope method was found to be 1.13 nM, which is substantially below the normal HSA concentration level in healthy urine, signifying the very high sensitivity of the probe toward HSA. The comparable results and quick response toward quantification of HSA in urine by HJRA with respect to the Bradford method clearly point toward the superiority of this method compared to the existing ones and may lead to biomedical applications for HSA quantification in urine. It may also find potential application in live-cell imaging of HSA." @default.
• W4310112198 created "2022-11-30" @default.
• W4310112198 creator A5026267613 @default.
• W4310112198 creator A5034212708 @default.
• W4310112198 creator A5036452925 @default.
• W4310112198 creator A5047895036 @default.
• W4310112198 creator A5053842109 @default.
• W4310112198 creator A5055382096 @default.
• W4310112198 date "2022-11-28" @default.
• W4310112198 modified "2023-10-14" @default.
• W4310112198 title "Serum Albumin Inspired Self-Assembly/Disassembly of a Fluorogenic Nanoprobe for Real-Time Monitoring and Quantification of Urinary Albumin with Live Cell Imaging Application" @default.
• W4310112198 cites W1775749144 @default.
• W4310112198 cites W1804485068 @default.
• W4310112198 cites W1965694893 @default.
• W4310112198 cites W1967923624 @default.
• W4310112198 cites W1972673148 @default.
• W4310112198 cites W1973238993 @default.
• W4310112198 cites W1973501329 @default.
• W4310112198 cites W1975586699 @default.
• W4310112198 cites W1978832930 @default.
• W4310112198 cites W1984589199 @default.
• W4310112198 cites W1989987616 @default.
• W4310112198 cites W1992406775 @default.
• W4310112198 cites W2000129317 @default.
• W4310112198 cites W2005760910 @default.
• W4310112198 cites W2014477053 @default.
• W4310112198 cites W2017654147 @default.
• W4310112198 cites W2020586838 @default.
• W4310112198 cites W2020994460 @default.
• W4310112198 cites W2022510326 @default.
• W4310112198 cites W2023813955 @default.
• W4310112198 cites W2031797041 @default.
• W4310112198 cites W2047417119 @default.
• W4310112198 cites W2047879084 @default.
• W4310112198 cites W2067023370 @default.
• W4310112198 cites W2074825817 @default.
• W4310112198 cites W2077061995 @default.
• W4310112198 cites W2078624700 @default.
• W4310112198 cites W2106690171 @default.
• W4310112198 cites W2113005044 @default.
• W4310112198 cites W2156101232 @default.
• W4310112198 cites W2157043696 @default.
• W4310112198 cites W2166528945 @default.
• W4310112198 cites W2167237931 @default.
• W4310112198 cites W2169219179 @default.
• W4310112198 cites W2177058120 @default.
• W4310112198 cites W2177603935 @default.
• W4310112198 cites W2179461561 @default.
• W4310112198 cites W2264468783 @default.
• W4310112198 cites W2290391889 @default.
• W4310112198 cites W2290577485 @default.
• W4310112198 cites W2314418723 @default.
• W4310112198 cites W2314933196 @default.
• W4310112198 cites W2315359473 @default.
• W4310112198 cites W2327480719 @default.
• W4310112198 cites W2334893650 @default.
• W4310112198 cites W2345476986 @default.
• W4310112198 cites W2404967489 @default.
• W4310112198 cites W2462502641 @default.
• W4310112198 cites W2468789868 @default.
• W4310112198 cites W2572187858 @default.
• W4310112198 cites W2586752554 @default.
• W4310112198 cites W2746240832 @default.
• W4310112198 cites W2749989088 @default.
• W4310112198 cites W2751452121 @default.
• W4310112198 cites W2804112936 @default.
• W4310112198 cites W2808124217 @default.
• W4310112198 cites W2903529806 @default.
• W4310112198 cites W2961459247 @default.
• W4310112198 cites W2982384185 @default.
• W4310112198 cites W3040723162 @default.
• W4310112198 cites W3045632226 @default.
• W4310112198 cites W3139139800 @default.
• W4310112198 cites W4200436606 @default.
• W4310112198 cites W4213193707 @default.
• W4310112198 cites W4248552008 @default.
• W4310112198 cites W4293247451 @default.
• W4310112198 cites W914506434 @default.
• W4310112198 doi "https://doi.org/10.1021/acsabm.2c00820" @default.
• W4310112198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36441947" @default.
• W4310112198 hasPublicationYear "2022" @default.
• W4310112198 type Work @default.
• W4310112198 citedByCount "1" @default.
• W4310112198 countsByYear W43101121982023 @default.
• W4310112198 crossrefType "journal-article" @default.
• W4310112198 hasAuthorship W4310112198A5026267613 @default.
• W4310112198 hasAuthorship W4310112198A5034212708 @default.
• W4310112198 hasAuthorship W4310112198A5036452925 @default.
• W4310112198 hasAuthorship W4310112198A5047895036 @default.
• W4310112198 hasAuthorship W4310112198A5053842109 @default.
• W4310112198 hasAuthorship W4310112198A5055382096 @default.
• W4310112198 hasConcept C119128265 @default.
• W4310112198 hasConcept C121332964 @default.
• W4310112198 hasConcept C12554922 @default.
• W4310112198 hasConcept C165616093 @default.
• W4310112198 hasConcept C166940927 @default.
• W4310112198 hasConcept C178790620 @default.
• W4310112198 hasConcept C185592680 @default.

• next