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• W4310118439 abstract "Abstract Camptothecin (CPT) is a potent chemotherapeutic agent for various cancers, but the broader application of CPT is still hindered by its poor bioavailability and systemic toxicity. Here, a prodrug that releases CPT in response to glutathione (GSH), which is commonly overexpressed by cancer cells is reported. Through assembling with PEGylated lipids, the prodrug is incorporated within as‐assembled nanoparticles, affording CPT with a prolonged half‐life in blood circulation, enhanced tumor targetingability, and improved therapeutic efficacy. Furthermore, such prodrug nanoparticles can also promote dendritic cell maturation and tumor infiltration of CD8 + T cells, providing a novel strategy to improve the therapeutic efficacy of CPT." @default.
• W4310118439 created "2022-11-30" @default.
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• W4310118439 date "2022-11-28" @default.
• W4310118439 modified "2023-10-05" @default.
• W4310118439 title "Glutathione‐Responsive Nanoparticles of Camptothecin Prodrug for Cancer Therapy" @default.
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• W4310118439 doi "https://doi.org/10.1002/advs.202205246" @default.
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