FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310127900> ?p ?o ?g. }

• W4310127900 endingPage "69" @default.
• W4310127900 startingPage "62" @default.
• W4310127900 abstract "It is increasingly recognized that a single protein can have multiple, sometimes paradoxical, roles in cell functions as well as pathological conditions depending on its cellular locations. Here we report that moesins (MSNs) in the intracellular and extracellular domains present opposing roles in pro-tumorigenic signaling in breast cancer cells. Using live cell imaging with fluorescence resonance energy transfer (FRET)- and green fluorescent protein (GFP)-based biosensors, we investigated the molecular mechanism underlying the cellular location-dependent effect of MSN on Src and β-catenin signaling in MDA-MB-231 breast cancer cells. Inhibition of intracellular MSN decreased the activities of Src and FAK, whereas overexpression of intracellular MSN increased them. By contrast, extracellular MSN decreased the activities of Src, FAK, and RhoA, as well as β-catenin translocation to the nucleus. Consistently, Western blotting and MTT-based analysis showed that overexpression of intracellular MSN elevated the expression of oncogenic genes, such as p-Src, β-catenin, Lrp5, MMP9, Runx2, and Snail, as well as cell viability, whereas extracellular MSN suppressed them. Conditioned medium derived from MSN-overexpressing mesenchymal stem cells or osteocytes showed the anti-tumor effects by inhibiting the Src activity and β-catenin translocation to the nucleus as well as the activities of FAK and RhoA and MTT-based cell viability. Conditioned medium derived from MSN-inhibited cells increased the Src activity, but it did not affect the activities of FAK and RhoA. Silencing CD44 and/or FN1 in MDA-MB-231 cells blocked the suppression of Src activity and β-catenin accumulation in the nucleus by extracellular MSN. Collectively, the results suggest that cellular location-specific MSN is a strong regulator of Src and β-catenin signaling in breast cancer cells, and that extracellular MSN exerts tumor-suppressive effects via its interaction with CD44 and FN1." @default.
• W4310127900 created "2022-11-30" @default.
• W4310127900 creator A5002252208 @default.
• W4310127900 creator A5008017308 @default.
• W4310127900 creator A5013738470 @default.
• W4310127900 creator A5072579976 @default.
• W4310127900 creator A5081940051 @default.
• W4310127900 creator A5091188222 @default.
• W4310127900 date "2023-01-01" @default.
• W4310127900 modified "2023-09-26" @default.
• W4310127900 title "Intracellular and extracellular moesins differentially regulate Src activity and β-catenin translocation to the nucleus in breast cancer cells" @default.
• W4310127900 cites W1593092365 @default.
• W4310127900 cites W1817790455 @default.
• W4310127900 cites W1964465038 @default.
• W4310127900 cites W1969342647 @default.
• W4310127900 cites W1970604527 @default.
• W4310127900 cites W1974321895 @default.
• W4310127900 cites W1989480741 @default.
• W4310127900 cites W1992082488 @default.
• W4310127900 cites W1995244622 @default.
• W4310127900 cites W2014866088 @default.
• W4310127900 cites W2022531767 @default.
• W4310127900 cites W2042015318 @default.
• W4310127900 cites W2052994710 @default.
• W4310127900 cites W2060758219 @default.
• W4310127900 cites W2069945609 @default.
• W4310127900 cites W2071359561 @default.
• W4310127900 cites W2076086205 @default.
• W4310127900 cites W2079407305 @default.
• W4310127900 cites W2092235352 @default.
• W4310127900 cites W2104477681 @default.
• W4310127900 cites W2108040056 @default.
• W4310127900 cites W2117571855 @default.
• W4310127900 cites W2122218045 @default.
• W4310127900 cites W2125092821 @default.
• W4310127900 cites W2144476583 @default.
• W4310127900 cites W2146054645 @default.
• W4310127900 cites W2147048296 @default.
• W4310127900 cites W2149598894 @default.
• W4310127900 cites W2171144176 @default.
• W4310127900 cites W2171232910 @default.
• W4310127900 cites W2591862276 @default.
• W4310127900 cites W2610193187 @default.
• W4310127900 cites W2745695439 @default.
• W4310127900 cites W2807204181 @default.
• W4310127900 cites W28112311 @default.
• W4310127900 cites W2903376111 @default.
• W4310127900 cites W2943754123 @default.
• W4310127900 cites W2971307936 @default.
• W4310127900 cites W3005307526 @default.
• W4310127900 cites W3137354412 @default.
• W4310127900 cites W3182969438 @default.
• W4310127900 cites W3210735354 @default.
• W4310127900 cites W4200492751 @default.
• W4310127900 cites W4233068112 @default.
• W4310127900 cites W4240629327 @default.
• W4310127900 doi "https://doi.org/10.1016/j.bbrc.2022.11.075" @default.
• W4310127900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36470073" @default.
• W4310127900 hasPublicationYear "2023" @default.
• W4310127900 type Work @default.
• W4310127900 citedByCount "0" @default.
• W4310127900 crossrefType "journal-article" @default.
• W4310127900 hasAuthorship W4310127900A5002252208 @default.
• W4310127900 hasAuthorship W4310127900A5008017308 @default.
• W4310127900 hasAuthorship W4310127900A5013738470 @default.
• W4310127900 hasAuthorship W4310127900A5072579976 @default.
• W4310127900 hasAuthorship W4310127900A5081940051 @default.
• W4310127900 hasAuthorship W4310127900A5091188222 @default.
• W4310127900 hasConcept C108636557 @default.
• W4310127900 hasConcept C121608353 @default.
• W4310127900 hasConcept C1491633281 @default.
• W4310127900 hasConcept C185592680 @default.
• W4310127900 hasConcept C2777093181 @default.
• W4310127900 hasConcept C28406088 @default.
• W4310127900 hasConcept C53227056 @default.
• W4310127900 hasConcept C54355233 @default.
• W4310127900 hasConcept C55493867 @default.
• W4310127900 hasConcept C62478195 @default.
• W4310127900 hasConcept C79879829 @default.
• W4310127900 hasConcept C86803240 @default.
• W4310127900 hasConcept C95444343 @default.
• W4310127900 hasConcept C96232424 @default.
• W4310127900 hasConceptScore W4310127900C108636557 @default.
• W4310127900 hasConceptScore W4310127900C121608353 @default.
• W4310127900 hasConceptScore W4310127900C1491633281 @default.
• W4310127900 hasConceptScore W4310127900C185592680 @default.
• W4310127900 hasConceptScore W4310127900C2777093181 @default.
• W4310127900 hasConceptScore W4310127900C28406088 @default.
• W4310127900 hasConceptScore W4310127900C53227056 @default.
• W4310127900 hasConceptScore W4310127900C54355233 @default.
• W4310127900 hasConceptScore W4310127900C55493867 @default.
• W4310127900 hasConceptScore W4310127900C62478195 @default.
• W4310127900 hasConceptScore W4310127900C79879829 @default.
• W4310127900 hasConceptScore W4310127900C86803240 @default.
• W4310127900 hasConceptScore W4310127900C95444343 @default.
• W4310127900 hasConceptScore W4310127900C96232424 @default.
• W4310127900 hasLocation W43101279001 @default.
• W4310127900 hasLocation W43101279002 @default.

• next