Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310150515> ?p ?o ?g. }
- W4310150515 endingPage "e0278096" @default.
- W4310150515 startingPage "e0278096" @default.
- W4310150515 abstract "The antifungal activity of the 70% ethanol stem bark extract of Erythrina senegalensis (ESB) against different strains and drug resistant clinical isolates of Candida albicans and Candida glabrata were evaluated in the study. The effect of ESB on biofilms as well as its activity in combination with fluconazole, nystatin or caspofungin against the Candida strains were also evaluated. We then evaluated the antifungal activity of a microemulsion formulation of ESB against planktonic and biofilms of the Candida species. UPLC-QTOF-MS2 analysis was then undertaken to identify the phytoconstituents of the extract and UPLC fingerprints developed for the routine authentication as part of quality control measures. ESB exerted strong antifungal activities against C. albicans ATCC 10231 and SC5314 strains, and C. glabrata ATCC 2001 strain with minimum inhibitory concentration (MIC) values from 3.91 to 31.25 μg/mL and minimum fungicidal concentrations (MFCs) that ranged from 62.5 to 250 μg/mL. It also exhibited potent antifungal activities (MIC = 4-64 μg/mL) against a collection of C. albicans and C. glabrata clinical isolates that were resistant to either nystatin or azole antifungals. The formulated ESB demonstrated higher antifungal potency against the C. albicans and C. glabrata strains with MIC values of 3.91-31.25 μg/mL which was the same as the MFC values. The extract and its microemulsion formulation were active against biofilms of the strains of the Candida species inhibiting their biofilm formations (SMIC50 = 16-64 μg/mL) and their preformed biofilms (SMIC50 = 128 ->512 μg/mL). ESB also exhibited synergistic antifungal action with fluconazole and nystatin against C. albicans ATCC 10231 and C. glabrata ATCC 2001 strains in the checkerboard assay. Chemical characterization of the extract revealed the presence of phenolic compounds such as flavonoids and their prenylated derivatives, anthracene glycosides and alkaloids. UPLC Fingerprints of the extract was also developed and validated for routine identification and authentication of the stem bark of E. senegalensis. The study findings have demonstrated that the stem bark of E. senegalensis is as a potential source of bioactive compounds that could be developed as novel antifungal agents." @default.
- W4310150515 created "2022-11-30" @default.
- W4310150515 creator A5007366348 @default.
- W4310150515 creator A5018637963 @default.
- W4310150515 creator A5028373085 @default.
- W4310150515 creator A5033527430 @default.
- W4310150515 creator A5045245811 @default.
- W4310150515 creator A5048412674 @default.
- W4310150515 creator A5054336261 @default.
- W4310150515 creator A5055192550 @default.
- W4310150515 creator A5079272001 @default.
- W4310150515 creator A5088511750 @default.
- W4310150515 date "2022-11-28" @default.
- W4310150515 modified "2023-10-15" @default.
- W4310150515 title "Metabolite profiling, antifungal, biofilm formation prevention and disruption of mature biofilm activities of Erythrina senegalensis stem bark extract against Candida albicans and Candida glabrata" @default.
- W4310150515 cites W1566592975 @default.
- W4310150515 cites W1896191564 @default.
- W4310150515 cites W1973166236 @default.
- W4310150515 cites W2010066062 @default.
- W4310150515 cites W2012252009 @default.
- W4310150515 cites W2021688176 @default.
- W4310150515 cites W2027300524 @default.
- W4310150515 cites W2052255778 @default.
- W4310150515 cites W2057777106 @default.
- W4310150515 cites W2085380798 @default.
- W4310150515 cites W2092531198 @default.
- W4310150515 cites W2107169184 @default.
- W4310150515 cites W2278571227 @default.
- W4310150515 cites W2279293317 @default.
- W4310150515 cites W2312506942 @default.
- W4310150515 cites W2346464968 @default.
- W4310150515 cites W2415657445 @default.
- W4310150515 cites W2532305189 @default.
- W4310150515 cites W2591084942 @default.
- W4310150515 cites W2604590883 @default.
- W4310150515 cites W2608385659 @default.
- W4310150515 cites W26549364 @default.
- W4310150515 cites W2739660851 @default.
- W4310150515 cites W2791432590 @default.
- W4310150515 cites W2884641450 @default.
- W4310150515 cites W2896191321 @default.
- W4310150515 cites W2970179945 @default.
- W4310150515 cites W3002248513 @default.
- W4310150515 cites W3002536749 @default.
- W4310150515 cites W3021777493 @default.
- W4310150515 cites W3026958586 @default.
- W4310150515 cites W3032806542 @default.
- W4310150515 cites W3126175474 @default.
- W4310150515 cites W3131506778 @default.
- W4310150515 cites W3147673708 @default.
- W4310150515 cites W4200368749 @default.
- W4310150515 cites W4200538488 @default.
- W4310150515 cites W4224213792 @default.
- W4310150515 cites W4230956988 @default.
- W4310150515 cites W4235064891 @default.
- W4310150515 cites W4253842255 @default.
- W4310150515 doi "https://doi.org/10.1371/journal.pone.0278096" @default.
- W4310150515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36441750" @default.
- W4310150515 hasPublicationYear "2022" @default.
- W4310150515 type Work @default.
- W4310150515 citedByCount "1" @default.
- W4310150515 countsByYear W43101505152023 @default.
- W4310150515 crossrefType "journal-article" @default.
- W4310150515 hasAuthorship W4310150515A5007366348 @default.
- W4310150515 hasAuthorship W4310150515A5018637963 @default.
- W4310150515 hasAuthorship W4310150515A5028373085 @default.
- W4310150515 hasAuthorship W4310150515A5033527430 @default.
- W4310150515 hasAuthorship W4310150515A5045245811 @default.
- W4310150515 hasAuthorship W4310150515A5048412674 @default.
- W4310150515 hasAuthorship W4310150515A5054336261 @default.
- W4310150515 hasAuthorship W4310150515A5055192550 @default.
- W4310150515 hasAuthorship W4310150515A5079272001 @default.
- W4310150515 hasAuthorship W4310150515A5088511750 @default.
- W4310150515 hasBestOaLocation W43101505151 @default.
- W4310150515 hasConcept C145081991 @default.
- W4310150515 hasConcept C176947019 @default.
- W4310150515 hasConcept C2777762789 @default.
- W4310150515 hasConcept C2779548794 @default.
- W4310150515 hasConcept C2779629538 @default.
- W4310150515 hasConcept C2780402444 @default.
- W4310150515 hasConcept C2780651595 @default.
- W4310150515 hasConcept C2780670043 @default.
- W4310150515 hasConcept C2780917455 @default.
- W4310150515 hasConcept C4937899 @default.
- W4310150515 hasConcept C523546767 @default.
- W4310150515 hasConcept C54355233 @default.
- W4310150515 hasConcept C58123911 @default.
- W4310150515 hasConcept C86803240 @default.
- W4310150515 hasConcept C89423630 @default.
- W4310150515 hasConceptScore W4310150515C145081991 @default.
- W4310150515 hasConceptScore W4310150515C176947019 @default.
- W4310150515 hasConceptScore W4310150515C2777762789 @default.
- W4310150515 hasConceptScore W4310150515C2779548794 @default.
- W4310150515 hasConceptScore W4310150515C2779629538 @default.
- W4310150515 hasConceptScore W4310150515C2780402444 @default.
- W4310150515 hasConceptScore W4310150515C2780651595 @default.
- W4310150515 hasConceptScore W4310150515C2780670043 @default.
- W4310150515 hasConceptScore W4310150515C2780917455 @default.