FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310159214> ?p ?o ?g. }

• W4310159214 endingPage "13185" @default.
• W4310159214 startingPage "13184" @default.
• W4310159214 abstract "Background Mantle cell lymphoma (MCL), a rare, aggressive lymphoid malignancy, accounts for 5-10% of non-Hodgkin lymphomas. Studies have recognized first-line autologous hematopoietic stem cell transplantation (ASCT) as a potential consolidative therapy in MCL for medically fit patients achieving complete remission following induction chemoimmunotherapy. However, treatment practices vary widely across institutions especially with the advent of novel targeted and cellular therapies. Safety-net hospitals have limitations in patients' access to treatment options like ASCT due to insurance barriers and treatment funding. This study analyzes the demographics, treatment patterns, and survival outcomes among MCL patients treated at a public safety-net hospital versus a private tertiary academic institution within the same healthcare system. The primary aim of the study was to analyze the utilization and impact of consolidative ASCT on survival outcomes in MCL patients. Methodology We conducted an IRB approved, retrospective review of 89 patients diagnosed with MCL who were treated within our healthcare system between January 2009 and December 2020. Primary variables analyzed include comparison of demographics, disease characteristics, chemo-based induction modalities, and survival outcomes. Hypothesis testing was performed using chi-square tests, t-tests, and other nonparametric tests as required, with a 2-tailed P value ≤ .05. Survival analysis for progression-free (PFS) and overall survival (OS) was performed with the Kaplan-Meier methodology and evaluated with the log rank test. Univariate and multivariate hazard regression was used to assess the relationship between pre-specified variables and primary endpoint of OS, and secondary endpoints of PFS, and time to next treatment (TTNT). Results Among the 89 patients with MCL, 25 (38%) were treated in a safety-net public hospital, whereas 64 (72%) were treated at a private academic center. Baseline characteristics are shown in Table 1. Significantly higher proportions of patients treated at the safety-net hospital were younger than 65 years (p = .004), African American (p<.0001), or Hispanic/Latino (p< .0001) compared to those treated at the academic institution. Thirty-six (41%) patients underwent consolidative ASCT, 29 (81%) in first complete remission (CR1). There were no significant differences in OS and PFS by the treating institution (p = .863 and p = .787, respectively) (Figure 1), ASCT status (p = .438 and p = .264, respectively), or use of maintenance Rituxan (p = .390 and p = .792, respectively). On multivariate analysis, there was no significant association between ASCT in CR1 and OS (HR 1.37; 95% CI, 0.38 to 4.93; p = .63), PFS (HR 0.40; 95% CI, 0.14 to 1.20; p = .10), or TTNT (HR 0.76; 95% CI, 0.29 to 2.01; p = .58). Conclusions: In this 'real world' analysis, first-line consolidative ASCT in CR1 for patients with MCL did not demonstrate an improvement in survival outcomes. Patients treated at the safety-net hospital had comparable outcomes to those treated at the tertiary academic hospital. These findings are likely multifactorial due to disease and patient heterogeneity, multidisciplinary standardized treatment practices at both sites, and novel therapeutics contributing to improved safety-net hospital outcomes. This study is limited by its small sample size and retrospective design. Prospective research evaluating the utility of consolidative ASCT in MCL has the potential to personalize treatment paradigms in this unique disease. Figure 1View largeDownload PPTFigure 1View largeDownload PPT Close modal" @default.
• W4310159214 created "2022-11-30" @default.
• W4310159214 creator A5008366988 @default.
• W4310159214 creator A5020499612 @default.
• W4310159214 creator A5021890434 @default.
• W4310159214 creator A5032566898 @default.
• W4310159214 creator A5039067043 @default.
• W4310159214 creator A5039548755 @default.
• W4310159214 creator A5043006593 @default.
• W4310159214 creator A5056755045 @default.
• W4310159214 creator A5059854479 @default.
• W4310159214 creator A5065394600 @default.
• W4310159214 creator A5083687186 @default.
• W4310159214 creator A5084302167 @default.
• W4310159214 creator A5089074892 @default.
• W4310159214 creator A5090985347 @default.
• W4310159214 date "2022-11-15" @default.
• W4310159214 modified "2023-09-29" @default.
• W4310159214 title "Impact of First-Line Consolidative Autologous Hematopoietic Stem Cell Transplantation (ASCT) in Mantle Cell Lymphoma (MCL): A 'Real-World' Study of Treatment Patterns and Outcomes at a Safety-Net Versus a Tertiary Academic Hospital" @default.
• W4310159214 doi "https://doi.org/10.1182/blood-2022-170764" @default.
• W4310159214 hasPublicationYear "2022" @default.
• W4310159214 type Work @default.
• W4310159214 citedByCount "0" @default.
• W4310159214 crossrefType "journal-article" @default.
• W4310159214 hasAuthorship W4310159214A5008366988 @default.
• W4310159214 hasAuthorship W4310159214A5020499612 @default.
• W4310159214 hasAuthorship W4310159214A5021890434 @default.
• W4310159214 hasAuthorship W4310159214A5032566898 @default.
• W4310159214 hasAuthorship W4310159214A5039067043 @default.
• W4310159214 hasAuthorship W4310159214A5039548755 @default.
• W4310159214 hasAuthorship W4310159214A5043006593 @default.
• W4310159214 hasAuthorship W4310159214A5056755045 @default.
• W4310159214 hasAuthorship W4310159214A5059854479 @default.
• W4310159214 hasAuthorship W4310159214A5065394600 @default.
• W4310159214 hasAuthorship W4310159214A5083687186 @default.
• W4310159214 hasAuthorship W4310159214A5084302167 @default.
• W4310159214 hasAuthorship W4310159214A5089074892 @default.
• W4310159214 hasAuthorship W4310159214A5090985347 @default.
• W4310159214 hasBestOaLocation W43101592141 @default.
• W4310159214 hasConcept C109159458 @default.
• W4310159214 hasConcept C126322002 @default.
• W4310159214 hasConcept C143998085 @default.
• W4310159214 hasConcept C2777408962 @default.
• W4310159214 hasConcept C2777525834 @default.
• W4310159214 hasConcept C2779050716 @default.
• W4310159214 hasConcept C2779338263 @default.
• W4310159214 hasConcept C28328180 @default.
• W4310159214 hasConcept C2911091166 @default.
• W4310159214 hasConcept C2993713153 @default.
• W4310159214 hasConcept C54355233 @default.
• W4310159214 hasConcept C71924100 @default.
• W4310159214 hasConcept C86803240 @default.
• W4310159214 hasConceptScore W4310159214C109159458 @default.
• W4310159214 hasConceptScore W4310159214C126322002 @default.
• W4310159214 hasConceptScore W4310159214C143998085 @default.
• W4310159214 hasConceptScore W4310159214C2777408962 @default.
• W4310159214 hasConceptScore W4310159214C2777525834 @default.
• W4310159214 hasConceptScore W4310159214C2779050716 @default.
• W4310159214 hasConceptScore W4310159214C2779338263 @default.
• W4310159214 hasConceptScore W4310159214C28328180 @default.
• W4310159214 hasConceptScore W4310159214C2911091166 @default.
• W4310159214 hasConceptScore W4310159214C2993713153 @default.
• W4310159214 hasConceptScore W4310159214C54355233 @default.
• W4310159214 hasConceptScore W4310159214C71924100 @default.
• W4310159214 hasConceptScore W4310159214C86803240 @default.
• W4310159214 hasIssue "Supplement 1" @default.
• W4310159214 hasLocation W43101592141 @default.
• W4310159214 hasOpenAccess W4310159214 @default.
• W4310159214 hasPrimaryLocation W43101592141 @default.
• W4310159214 hasRelatedWork W2010848952 @default.
• W4310159214 hasRelatedWork W2033219189 @default.
• W4310159214 hasRelatedWork W2314368967 @default.
• W4310159214 hasRelatedWork W2319149848 @default.
• W4310159214 hasRelatedWork W2344804063 @default.
• W4310159214 hasRelatedWork W2386230525 @default.
• W4310159214 hasRelatedWork W2414647507 @default.
• W4310159214 hasRelatedWork W2473651207 @default.
• W4310159214 hasRelatedWork W2944683649 @default.
• W4310159214 hasRelatedWork W2966469474 @default.
• W4310159214 hasVolume "140" @default.
• W4310159214 isParatext "false" @default.
• W4310159214 isRetracted "false" @default.
• W4310159214 workType "article" @default.