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- W4310168997 abstract "Knee osteoarthritis (KOA), whose prevalence keeps rising, is still unsolved pathobiological/therapeutical problem. Historically, knee osteoarthritis was thought to be a wear and tear disease, while recent etiology hypotheses stressed it as a chronic, low-grade inflammatory disease. Inflammasomes mediated by the innate immunity systems have an important role in inflammatory diseases including KOA. A deluge of recent studies focused on the NLRP3 inflammasome with suggestions that its pharmacologic block would hinder degeneration. However, known inflammasomes are numerous and can also trigger IL-1β/IL-18 production and cells' pyroptotic death. Among them, AIM2 inflammasome is involved in key aspects of various acute and chronic inflammatory diseases. Therefore, while presently leaving out little-studied inflammasomes in KOA, this review focuses on the AIM2 inflammasomes that participate in KOA's complex mechanisms in conjunction with the activation of AIM2 inflammasomes in other diseases combined with the current studies on KOA mechanisms. Although human-specific data about it are relatively scant, we stress that only a holistic view including several inflammasomes including AIM2 inflammasome and other potential pathogenetic drivers will lead to successful therapy for knee osteoarthritis." @default.
- W4310168997 created "2022-11-30" @default.
- W4310168997 creator A5001451095 @default.
- W4310168997 creator A5073555496 @default.
- W4310168997 date "2022-11-01" @default.
- W4310168997 modified "2023-09-30" @default.
- W4310168997 title "The Role of AIM2 Inflammasome in Knee Osteoarthritis" @default.
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- W4310168997 doi "https://doi.org/10.2147/jir.s392652" @default.
- W4310168997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36467990" @default.
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