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• W4310169439 abstract "The antimicrobial action of gold depends on different factors including its oxidation state in the intra- and extracellular medium, the redox potential, its ability to produce reactive oxygen species (ROS), the medium components, the properties of the targeted bacteria wall, its penetration in the bacterial cytosol, the cell membrane potential, and its interaction with intracellular components. We demonstrate that different gold species are able to induce bacterial wall damage as a result of their electrostatic interaction with the cell membrane, the promotion of ROS generation, and the consequent DNA damage. In-depth genomic and proteomic studies on Escherichia coli confirmed the superior toxicity of Au (III) vs Au (I) based on the different molecular mechanisms analyzed including oxidative stress, bacterial energetic metabolism, biosynthetic processes, and cell transport. At equivalent bactericidal doses of Au (III) and Au (I) eukaryotic cells were not as affected as bacteria did, maintaining unaffected cell viability, morphology, and focal adhesions; however, increased ROS generation and disruption in the mitochondrial membrane potential were also observed. Herein, we shed light on the antimicrobial mechanisms of ionic and biogenic gold nanoparticles against bacteria. Under selected conditions antibiotic-like ionic gold can exert a strong antimicrobial activity while being harmless to human cells." @default.
• W4310169439 created "2022-11-30" @default.
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• W4310169439 date "2023-03-01" @default.
• W4310169439 modified "2023-10-12" @default.
• W4310169439 title "Elucidating the mechanisms of action of antibiotic-like ionic gold and biogenic gold nanoparticles against bacteria" @default.
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• W4310169439 doi "https://doi.org/10.1016/j.jcis.2022.11.138" @default.
• W4310169439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36493743" @default.
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