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• W4310171522 abstract "Two bicyclic annulated isothiourea derivatives were synthesized using as a key stage either the reaction of isothiocyanate halide with sodium sulfide or cyclization of unsaturated thiourea in the presence of bromine. X-ray molecular structure of N-[(3aSR,7aRS,Z)-hexahydro-1,3-benzothiazol-2(3H)-ylidene]glycine was determined. The conjugate of colchicine with [(3aR,5S,6aS)-2-(tert-butylamino)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]thiazol-5-yl]methanol obtained demonstrated pronounced cytotoxic effect on cancer cells." @default.
• W4310171522 created "2022-11-30" @default.
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• W4310171522 date "2022-11-01" @default.
• W4310171522 modified "2023-09-25" @default.
• W4310171522 title "Bicyclic isothioureas for conjugation with tubulin targeted anticancer agents" @default.
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• W4310171522 doi "https://doi.org/10.1016/j.mencom.2022.11.019" @default.
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