Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310172008> ?p ?o ?g. }
- W4310172008 endingPage "15828" @default.
- W4310172008 startingPage "15828" @default.
- W4310172008 abstract "Developmental toxicity testing urgently requires the implementation of human-relevant new approach methodologies (NAMs) that better recapitulate the peculiar nature of human physiology during pregnancy, especially the placenta and the maternal/fetal interface, which represent a key stage for human lifelong health. Fit-for-purpose NAMs for the placental-fetal interface are desirable to improve the biological knowledge of environmental exposure at the molecular level and to reduce the high cost, time and ethical impact of animal studies. This article reviews the state of the art on the available in vitro (placental, fetal and amniotic cell-based systems) and in silico NAMs of human relevance for developmental toxicity testing purposes; in addition, we considered available Adverse Outcome Pathways related to developmental toxicity. The OECD TG 414 for the identification and assessment of deleterious effects of prenatal exposure to chemicals on developing organisms will be discussed to delineate the regulatory context and to better debate what is missing and needed in the context of the Developmental Origins of Health and Disease hypothesis to significantly improve this sector. Starting from this analysis, the development of a novel human feto-placental organ-on-chip platform will be introduced as an innovative future alternative tool for developmental toxicity testing, considering possible implementation and validation strategies to overcome the limitation of the current animal studies and NAMs available in regulatory toxicology and in the biomedical field." @default.
- W4310172008 created "2022-11-30" @default.
- W4310172008 creator A5016806501 @default.
- W4310172008 creator A5034162766 @default.
- W4310172008 creator A5040675321 @default.
- W4310172008 creator A5050333703 @default.
- W4310172008 creator A5058133879 @default.
- W4310172008 creator A5060216077 @default.
- W4310172008 creator A5063868414 @default.
- W4310172008 creator A5065071429 @default.
- W4310172008 creator A5065178403 @default.
- W4310172008 creator A5084564826 @default.
- W4310172008 date "2022-11-28" @default.
- W4310172008 modified "2023-10-01" @default.
- W4310172008 title "Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto–Placental Organ-on-Chip Platform" @default.
- W4310172008 cites W1521814243 @default.
- W4310172008 cites W1530881143 @default.
- W4310172008 cites W1537220258 @default.
- W4310172008 cites W1606293095 @default.
- W4310172008 cites W1739877739 @default.
- W4310172008 cites W1770292777 @default.
- W4310172008 cites W1841600388 @default.
- W4310172008 cites W1846363290 @default.
- W4310172008 cites W1871196409 @default.
- W4310172008 cites W1971576406 @default.
- W4310172008 cites W1973412840 @default.
- W4310172008 cites W1988984170 @default.
- W4310172008 cites W1991681537 @default.
- W4310172008 cites W1992696528 @default.
- W4310172008 cites W1994093536 @default.
- W4310172008 cites W1995370499 @default.
- W4310172008 cites W1996732248 @default.
- W4310172008 cites W2004247546 @default.
- W4310172008 cites W2004912053 @default.
- W4310172008 cites W2005526872 @default.
- W4310172008 cites W2008411429 @default.
- W4310172008 cites W2010570746 @default.
- W4310172008 cites W2014085294 @default.
- W4310172008 cites W2015560811 @default.
- W4310172008 cites W2016183704 @default.
- W4310172008 cites W2017581448 @default.
- W4310172008 cites W20181848 @default.
- W4310172008 cites W2023527700 @default.
- W4310172008 cites W2024113719 @default.
- W4310172008 cites W2026646284 @default.
- W4310172008 cites W2032293323 @default.
- W4310172008 cites W2033284482 @default.
- W4310172008 cites W2034813267 @default.
- W4310172008 cites W2035741084 @default.
- W4310172008 cites W2036193524 @default.
- W4310172008 cites W2044072193 @default.
- W4310172008 cites W2045448352 @default.
- W4310172008 cites W2046504912 @default.
- W4310172008 cites W2050742889 @default.
- W4310172008 cites W2060297397 @default.
- W4310172008 cites W2061372638 @default.
- W4310172008 cites W2066478796 @default.
- W4310172008 cites W2074716149 @default.
- W4310172008 cites W2078201066 @default.
- W4310172008 cites W2078786713 @default.
- W4310172008 cites W2091069527 @default.
- W4310172008 cites W2091437304 @default.
- W4310172008 cites W2092244800 @default.
- W4310172008 cites W2100256737 @default.
- W4310172008 cites W2101399594 @default.
- W4310172008 cites W2103414388 @default.
- W4310172008 cites W2108482850 @default.
- W4310172008 cites W2112464771 @default.
- W4310172008 cites W2116078884 @default.
- W4310172008 cites W2117692326 @default.
- W4310172008 cites W2118056724 @default.
- W4310172008 cites W2120095635 @default.
- W4310172008 cites W2122546244 @default.
- W4310172008 cites W2128800067 @default.
- W4310172008 cites W2129501023 @default.
- W4310172008 cites W2135543510 @default.
- W4310172008 cites W2137454940 @default.
- W4310172008 cites W2138695945 @default.
- W4310172008 cites W2138865735 @default.
- W4310172008 cites W2143237309 @default.
- W4310172008 cites W2145175488 @default.
- W4310172008 cites W2145380161 @default.
- W4310172008 cites W2165451199 @default.
- W4310172008 cites W2169413646 @default.
- W4310172008 cites W2171342967 @default.
- W4310172008 cites W2268840182 @default.
- W4310172008 cites W2328574836 @default.
- W4310172008 cites W2329674104 @default.
- W4310172008 cites W2333402211 @default.
- W4310172008 cites W2346493992 @default.
- W4310172008 cites W2369777548 @default.
- W4310172008 cites W2413518158 @default.
- W4310172008 cites W2463039685 @default.
- W4310172008 cites W2491430868 @default.
- W4310172008 cites W2503656250 @default.
- W4310172008 cites W2510028748 @default.
- W4310172008 cites W2526026918 @default.
- W4310172008 cites W2530431372 @default.