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- W4310172011 abstract "The development of a simple local drug-delivery system that exhibits the advantages of macro- and microscale carriers with controllable drug-release behavior is still highly desired. Herein, in this work, a smart temporary film was prepared from doxorubicin (DOX)-loaded shape-memory microgels via a simple hot-compression programming method. The temporary film showed a very smooth surface and easy handing, as well as macroscopy mechanical properties, which could disintegrate into the microgels with heating at 45 °C. In this case, the temporary film showed a controllable DOX release behavior when compared with the microgels, which could release the DOX on demand. Consequently, the temporary film exhibited weaker cytotoxicity to normal cells and a much longer antitumor capability, as well as a higher drug-utilization efficiency when compared with microgels. Therefore, the smart temporary film has high potential as a candidate for use as a local drug-delivery system." @default.
- W4310172011 created "2022-11-30" @default.
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- W4310172011 date "2022-11-27" @default.
- W4310172011 modified "2023-09-26" @default.
- W4310172011 title "Smart-Temporary-Film-Based Local-Delivery System with Controllable Drug-Release Behavior" @default.
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- W4310172011 doi "https://doi.org/10.3390/gels8120773" @default.
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