FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310177445> ?p ?o ?g. }

• W4310177445 endingPage "7011" @default.
• W4310177445 startingPage "7011" @default.
• W4310177445 abstract "POEMS is a rare clonal plasma cell disorder characterized by multi-systemic features that include demyelinating peripheral neuropathy, organomegaly, endocrinopathy, presence of monoclonal proteins (M-protein), and skin changes. Even though the pathophysiology is poorly understood, recent studies suggest that both clonal and polyclonal plasmacytosis leading to the production of pro-inflammatory cytokines and angiogenic mediators play the central role. These mediators including vascular endothelial growth factor (VEGF) are the driving forces of the syndrome. The diagnosis of POEMS is not always straight forward and often the diagnosis is delayed. It is based on fulfilling mandatory criteria of polyradiculoneuropathy and monoclonal protein and the presence of one major criterion (Castleman disease, sclerotic bone lesions, or elevated VEGF), and at least one minor criterion. Due to the presence of neuropathy, it can be confused with chronic inflammatory demyelinating polyradiculopathy (CIDP), and if thrombocytosis and splenomegaly are present, it can be confused with myeloproliferative neoplasms. Due to the rarity of the syndrome, clear guidelines for treatment are still lacking. Immediate treatment targeting the underlying plasma cell proliferation results in a dramatic response in most patients. The key is early diagnosis and immediate anti-plasma cell directed therapy for the best clinical outcomes. For patients with disseminated disease as defined by bone marrow involvement or more than three osteosclerotic bone lesions, high-dose chemotherapy with autologous hematopoietic stem cell transplant (ASCT) yields durable responses and is the preferred treatment in eligible patients. For patients with localized bony disease, radiotherapy has proven to be very effective. Lenalidomide and dexamethasone is a proven therapy in patients ineligible for ASCT. In this review article, we tackle the diagnostic approach and discuss the latest treatment modalities of this rare debilitating disease." @default.
• W4310177445 created "2022-11-30" @default.
• W4310177445 creator A5015788207 @default.
• W4310177445 creator A5023403225 @default.
• W4310177445 creator A5070206086 @default.
• W4310177445 creator A5076600488 @default.
• W4310177445 date "2022-11-27" @default.
• W4310177445 modified "2023-10-05" @default.
• W4310177445 title "Recent Advances in the Treatment and Supportive Care of POEMS Syndrome" @default.
• W4310177445 cites W1263132924 @default.
• W4310177445 cites W130834775 @default.
• W4310177445 cites W150778959 @default.
• W4310177445 cites W1528918582 @default.
• W4310177445 cites W1815434698 @default.
• W4310177445 cites W1834852860 @default.
• W4310177445 cites W1838932391 @default.
• W4310177445 cites W185954562 @default.
• W4310177445 cites W1952760452 @default.
• W4310177445 cites W1965183980 @default.
• W4310177445 cites W1965977684 @default.
• W4310177445 cites W1966714645 @default.
• W4310177445 cites W1966868722 @default.
• W4310177445 cites W1971416647 @default.
• W4310177445 cites W1974135782 @default.
• W4310177445 cites W1974547871 @default.
• W4310177445 cites W1974785629 @default.
• W4310177445 cites W1977348505 @default.
• W4310177445 cites W1980171506 @default.
• W4310177445 cites W1981313177 @default.
• W4310177445 cites W1982154014 @default.
• W4310177445 cites W1983182895 @default.
• W4310177445 cites W1986573165 @default.
• W4310177445 cites W1987683015 @default.
• W4310177445 cites W1988186308 @default.
• W4310177445 cites W1988663536 @default.
• W4310177445 cites W1989698080 @default.
• W4310177445 cites W1995486690 @default.
• W4310177445 cites W1999943742 @default.
• W4310177445 cites W2009069105 @default.
• W4310177445 cites W2009561053 @default.
• W4310177445 cites W2014127030 @default.
• W4310177445 cites W2015329833 @default.
• W4310177445 cites W2016229037 @default.
• W4310177445 cites W2019640375 @default.
• W4310177445 cites W2025555311 @default.
• W4310177445 cites W2027742754 @default.
• W4310177445 cites W2027879458 @default.
• W4310177445 cites W2030465811 @default.
• W4310177445 cites W2031086586 @default.
• W4310177445 cites W2032048924 @default.
• W4310177445 cites W2033793452 @default.
• W4310177445 cites W2034798596 @default.
• W4310177445 cites W2035834427 @default.
• W4310177445 cites W2036358176 @default.
• W4310177445 cites W2038193784 @default.
• W4310177445 cites W2039261792 @default.
• W4310177445 cites W2039724386 @default.
• W4310177445 cites W2040978620 @default.
• W4310177445 cites W2041420084 @default.
• W4310177445 cites W2043590047 @default.
• W4310177445 cites W2046840192 @default.
• W4310177445 cites W2053289260 @default.
• W4310177445 cites W2054888616 @default.
• W4310177445 cites W2055500870 @default.
• W4310177445 cites W2059736302 @default.
• W4310177445 cites W2061015763 @default.
• W4310177445 cites W2061108137 @default.
• W4310177445 cites W2061738284 @default.
• W4310177445 cites W2063493287 @default.
• W4310177445 cites W2066743269 @default.
• W4310177445 cites W2066994535 @default.
• W4310177445 cites W2070530010 @default.
• W4310177445 cites W2074373558 @default.
• W4310177445 cites W2075068942 @default.
• W4310177445 cites W2075681466 @default.
• W4310177445 cites W2077674677 @default.
• W4310177445 cites W2078960453 @default.
• W4310177445 cites W2078978399 @default.
• W4310177445 cites W2091342521 @default.
• W4310177445 cites W2092597335 @default.
• W4310177445 cites W2094686973 @default.
• W4310177445 cites W2095148874 @default.
• W4310177445 cites W2100954596 @default.
• W4310177445 cites W2102436856 @default.
• W4310177445 cites W2105421621 @default.
• W4310177445 cites W2106390063 @default.
• W4310177445 cites W2106597626 @default.
• W4310177445 cites W2106749259 @default.
• W4310177445 cites W2121956456 @default.
• W4310177445 cites W2123789589 @default.
• W4310177445 cites W2130482806 @default.
• W4310177445 cites W2132160266 @default.
• W4310177445 cites W2139100518 @default.
• W4310177445 cites W2144790906 @default.
• W4310177445 cites W2152311971 @default.
• W4310177445 cites W2153947189 @default.
• W4310177445 cites W2158794607 @default.
• W4310177445 cites W2159694977 @default.

• next